Effect of mycophenolate mofetil on the white blood cell count and the frequency of infection in systemic lupus erythematosus.

Leukopenia is a common manifestation of SLE. Addition of immunosuppressive therapy in a SLE patient who is already leukopenic is a clinical concern. It could worsen leukopenia, increase the risk of infection, or both. The aim of this study was to analyze the immediate effect of mycophenolate mofetil on the white blood cell count and the rate of infection in SLE patients. Two hundred and forty-four patients within the Hopkins Lupus Cohort who were newly started on mycophenolate mofetil were included in the study. The white blood cell count and interval infection history on the day mycophenolate mofetil was started were compared with the white blood cell count and interval infection history at the next visit. The study was based on 244 patients who began taking mycophenolate mofetil in the cohort. The study population included 47 % African Americans, 44 % Caucasians, and 9 % other ethnicities. There was a slight but not statistically significant increase in the white blood cell count (6.63 vs. 7.01), after starting mycophenolate mofetil. Patients with a baseline white blood cell count \u3c3000/mm(3) did have a statistically significant increase in the white blood cell count after starting mycophenolate mofetil (2.57 vs. 5.13, P = 0.0047). We also found a statistically significant increase in the risk of bacterial infection (but not viral infection) after starting mycophenolate mofetil (4 vs. 9 %, P = 0.0036). Leukopenia does not worsen with mycophenolate mofetil. However, mycophenolate mofetil appears to slightly increase the rate of bacterial (but not viral) infection

Coupling internal atomic states in a two-component Bose-Einstein condensate via an optical lattice: Extended Mott-superfluid transitions

An ultracold gas of coupled two-component atoms in an optical field is studied. Due to the internal two-level structure of the atoms, three competing energy terms exist; atomic kinetic, atomic internal, and atom-atom interaction energies. A novel outcome of this interplay, not present in the regular Bose-Hubbard model, is that in the single band and tight binding approximations four different phases appear: two superfluid and two Mott phases. When passing through the critical point between the two superfluid or the two Mott phases, a swapping of the internal atomic populations takes place. By means of the strong coupling expansion, we find the full phase diagram for the four different phases.Comment: 9 pages, 7 figure

A thermodynamical fiber bundle model for the fracture of disordered materials

We investigate a disordered version of a thermodynamic fiber bundle model proposed by Selinger, Wang, Gelbart, and Ben-Shaul a few years ago. For simple forms of disorder, the model is analytically tractable and displays some new features. At either constant stress or constant strain, there is a non monotonic increase of the fraction of broken fibers as a function of temperature. Moreover, the same values of some macroscopic quantities as stress and strain may correspond to different microscopic cofigurations, which can be essential for determining the thermal activation time of the fracture. We argue that different microscopic states may be characterized by an experimentally accessible analog of the Edwards-Anderson parameter. At zero temperature, we recover the behavior of the irreversible fiber bundle model.Comment: 18 pages, 10 figure

Analysis of interface conversion processes of ballistic and diffusive motion in driven superlattices

We explore the non-equilibrium dynamics of non-interacting classical particles in a one-dimensional driven superlattice which is composed of domains exposed to different time-dependent forces. It is shown how the combination of directed transport and conversion processes from diffusive to ballistic motion causes strong correlations between velocity and phase for particles passing through a superlattice. A detailed understanding of the underlying mechanism allows us to tune the resulting velocity distributions at distinguished points in the superlattice by means of local variations of the applied driving force. As an intriguing application we present a scheme how initially diffusive particles can be transformed into a monoenergetic pulsed particle beam whose parameters such as its energy can be varied

Somatostatin agonist pasireotide inhibits exercise stimulated growth in the male Siberian hamster (Phodopus sungorus)

R.Dumbell was supported by a University of Aberdeen PhD studentship and a research visit grant awarded by the British Society of Neuroendocrinology. Further support was provided by the Scottish Government Rural and Environment Science and Analytical Services Division (Barrett and the German Research Foundation (DFG; STE 331/8-1; Steinlechner lab). We are grateful for technical assistance from Dana Wilson at RINH and Siegried Hiliken at UVMH, and thank Dr Claus-Dieter Mayer of Biomathematics & Statistics Scotland for valuable advice on statistical analysis.Peer reviewedPostprin

Glassy behaviour in short range lattice models without quenched disorder

We investigate the quenching process in lattice systems with short range interaction and several crystalline states as ground states. We consider in particular the following systems on square lattice: - hard particle (exclusion) model; - q states planar Potts model. The system is initially in a homogeneous disordered phase and relaxes toward a new equilibrium state as soon as the temperature is rapidly lowered. The time evolution can be described numerically by a stochastic process such as the Metropolis algorithm. The number of pure, equivalent, ground states is q for the Potts model and r for the hard particle model, and it is known that for r or q larger or equal to d+1, the final equilibrium state may be polycrystalline, i.e. not made of a uniform phase. We find that in addition n_g and q_g exist such that for r > r_g, or q > q_g the system evolves toward a glassy state, i.e. a state in which the ratio of the interaction energy among the different crystalline phases to the total energy of the system never vanishes; moreover we find indications that r_g=q_g. We infer that q=q_g (and r=r_g) corresponds to the crossing from second order to discontinuous transition in the phase diagram of the system.Comment: 10 pages, 3 figure

Exponential torsion growth for random 3-manifolds

We show that a random 3-manifold with positive first Betti number admits a tower of cyclic covers with exponential torsion growth

Mobility Impacts of the Second Phase of Covid-19: General Considerations and Regulation from Tuscany (Italy) and Kentucky (USA)

he second phase of the virus Covid-19 is about to start a new configuration of accessibility to activities and cities. This phase, which will be able to see different restriction levels both between different countries and between successive periods, is the great challenge that the whole world is facing and which, if not managed in a planned and strategic way, risks turning into a further catastrophe. The social distancing rules imposed will necessarily lead to an escape from public transport in the cities, which could turn into total congestion of city traffic, leading the cities themselves to paralysis. We need a series of countermeasures that define new mobility capable of mitigating the effects of the mobility offer imbalance by intervening quickly, economically, and, in the short term, emergency on the whole transport chain. This article presents some possible actions to be put in place, and some mobility measures actually applied in Tuscany coastal area. © 2020, Springer Nature Switzerland AG