61 research outputs found
FORMULATION AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM CONTAINING COMBINATION OF GLIPIZIDE AND METFORMIN HYDROCHLORIDE
The purpose of gastro-retentive drug delivery systems was special focus on the principle mechanism of floatation to achieve gastric retention. The objective is to develop a gastro-retentive drug delivery system of Glipizide and Metformine hydrochloride is to overcome the biggest problem in oral drug delivery is low and erratic drug bioavailability. Glipizide and Metformine hydrochloride are used for the treatment of diabetes mellitus. Seven formulations containing retardant material and alkalizing agent were prepared with solubilizing agent in different ratio. The ability of various polymers to retain the drug when used in different concentrations was investigated. It was found that sodium bicarbonate reacts with HCl and produce CO2 which creates pores in tablet and elevates swelling by wetting polymer. So it helps in maintaining the buoyancy. The release rate could be modified by varying the polymer ratio, concentration of alkalizing and solubilizing agent. The prepared tablets were evaluated for general appearance, content uniformity, hardness, friability, buoyancy and in vitro dissolution studies
Mucosa-Associated Microbiota in Barrett’s Esophagus, Dysplasia, and Esophageal Adenocarcinoma Differ Similarly Compared With Healthy Controls
INTRODUCTION: Alterations in the composition of the human gut microbiome and its metabolites have been linked to gut epithelial neoplasia. We hypothesized that differences in mucosa-adherent Barrett’s microbiota could link to risk factors, providing risk of progression to neoplasia.
METHODS: Paired biopsies from both diseased and nonaffected esophagus (as well as gastric cardia and gastric juice for comparison) from patients with intestinal metaplasia (n 5 10), low grade dysplasia (n 5 10), high grade dysplasia (n 5 10), esophageal adenocarcinoma (n 5 12), and controls (n 5 10) were processed for mucosa-associated bacteria and analyzed by 16S ribosomal ribonucleic acid V4 gene DNA sequencing. Taxa composition was tested using a generalized linear model based on the negative binomial distribution and the log link functions of the R Bioconductor package edgeR.
RESULTS: The microbe composition of paired samples (disease vs nondisease) comparing normal esophagus with intestinal metaplasia, low grade dysplasia, high grade dysplasia, and adenocarcinoma showed significant decreases in the phylum Planctomycetes and the archaean phylum Crenarchaeota (P \u3c 0.05, false discovery rate corrected) in diseased tissue compared with healthy controls and intrasample controls (gastric juice and unaffected mucosa). Genera Siphonobacter, Balneola, Nitrosopumilus, and Planctomyces were significantly decreased (P \u3c 0.05, false discovery rate corrected), representing \u3c10% of the entire genus community. These changes were unaffected by age, tobacco use, or sex for Crenarcha.
DISCUSSSION: There are similar significant changes in bacterial genera in Barrett’s esophagealmucosa, dysplasia, and adenocarcinoma compared with controls and intrapatient unaffected esophagus. Further work will establish the biologic plausibility of these specific microbes’ contributions to protection from or induction of esophageal epithelial dysplasia.
Includes supplemental file
Colon Capsule Endoscopy compared to Conventional Colonoscopy under routine screening conditions
Colonoscopy (CSPY) for colorectal cancer screening has several limitations. Colon Capsule Endoscopy (PillCam Colon, CCE) was compared to CSPY under routine screening conditions
Mo1163 Prevalence and Impact of Upper Gastrointestinal Bleeding on In-Hospital Mortality and Hospital Resource Utilization Among Patients With Solid Organ Transplantation
Mucosa-Associated Microbiota in Barrett’s Esophagus, Dysplasia, and Esophageal Adenocarcinoma Differ Similarly Compared With Healthy Controls
INTRODUCTION: Alterations in the composition of the human gut microbiome and its metabolites have been linked to gut epithelial neoplasia. We hypothesized that differences in mucosa-adherent Barrett’s microbiota could link to risk factors, providing risk of progression to neoplasia.
METHODS: Paired biopsies from both diseased and nonaffected esophagus (as well as gastric cardia and gastric juice for comparison) from patients with intestinal metaplasia (n 5 10), low grade dysplasia (n 5 10), high grade dysplasia (n 5 10), esophageal adenocarcinoma (n 5 12), and controls (n 5 10) were processed for mucosa-associated bacteria and analyzed by 16S ribosomal ribonucleic acid V4 gene DNA sequencing. Taxa composition was tested using a generalized linear model based on the negative binomial distribution and the log link functions of the R Bioconductor package edgeR.
RESULTS: The microbe composition of paired samples (disease vs nondisease) comparing normal esophagus with intestinal metaplasia, low grade dysplasia, high grade dysplasia, and adenocarcinoma showed significant decreases in the phylum Planctomycetes and the archaean phylum Crenarchaeota (P \u3c 0.05, false discovery rate corrected) in diseased tissue compared with healthy controls and intrasample controls (gastric juice and unaffected mucosa). Genera Siphonobacter, Balneola, Nitrosopumilus, and Planctomyces were significantly decreased (P \u3c 0.05, false discovery rate corrected), representing \u3c10% of the entire genus community. These changes were unaffected by age, tobacco use, or sex for Crenarcha.
DISCUSSSION: There are similar significant changes in bacterial genera in Barrett’s esophagealmucosa, dysplasia, and adenocarcinoma compared with controls and intrapatient unaffected esophagus. Further work will establish the biologic plausibility of these specific microbes’ contributions to protection from or induction of esophageal epithelial dysplasia.
Includes supplemental file
2866 Association of Metabolic Syndrome in Patients With Barrett’s Esophagus With High-Grade Dysplasia Compared to Low-Grade Dysplasia
S1218 Somatostatin Analogues Are Effective Rescue Therapy for Chronic Bleeding from Gastrointestinal Angiodysplasia: A Meta-Analysis of Prospective Cohort Studies
- …