Supplier search in industrial clusters: Sheffield metal working in the 1990s

Industrial clusters can be characterised by high levels of personal interaction between the owners/managers of firms. It has been argued that within industrial clusters community and firm tend to merge. One result of the notion of a cluster as a community is that it might be expected that personal interaction between members of the community will have an important influence on intra-cluster trading patterns. Whereas there appears to be a number of anecdotal stories of the impact of the 'personal' upon the 'economic' within clusters we do not know whether such relationships are uniquely part of cluster behaviour or whether they are found more widely within the industrial system. The paper reports the result of a new interview survey of seventy small metal working firms in the Sheffield metal working cluster in the UK. Although dealing with a traditional industrial sector the analysis is focused upon contemporary business patterns. It explores the ways in which owner/managers of small metal working firms search for new suppliers. In the empirical analysis the search process is conceptualised as being characterised by two stages: the identification of potential new suppliers and the selection of a specific new supplier. The research is in undertaken in two parts. It first measures the role of the personal networks of the owner/managers of small firms in the identification and selection of suppliers. Second, the research examines whether personal factors are more important in the identification and selection of within cluster suppliers than in the identification and selection of suppliers based outside the cluster. It is shown that, overall, personal networks are of major significance in the identification of suppliers and that information received from third parties are more important than direct contacts between the owner/manager and the potential supplier. However, in the selection decision, price and availability are dominant considerations and personal factors such as trust and reputation of only minor significance. It was not possible to identify a cluster effect in disaggregation of the data to separate out the relationships with cluster suppliers and relationships with suppliers based outside the cluster. There was no evidence that personal factors play a more important role in the establishment of within cluster links. In sum, personal networks are important in the identification of within cluster links but they are equally important in the establishment of links outside the cluster. This suggests that the importance of personal interaction within clusters has been overplayed.

Unsteady-State Diffusion of Moisture In Giant Timber Bamboo (Phyllostachys Bambusoides Sieb. & Zucc.)

This paper presents the results of a study to determine the rate of moisture movement in giant timber bamboo (Phyllostachys bambusoides Sieb. & Zucc.) when exposed to three different temperatures (20 C, 30 C, and 40 C) at two ranges of moisture content (0 to 7.5%, and 7.5 to 15%). Edge-coated samples measuring 6 mm (R) x 30 mm (T) x 150 mm (L) were exposed to a given temperature-humidity combination in a conditioning chamber. The weight of a sample was continuously monitored over time and the weight-time data were analyzed using the Boltzmann solution to the unsteady-state form of Fick's diffusion equation.Diffusion coefficients ranged from 7.3 x 10~12 to 7.8 x 10~11 m2/sec. They were greater at the higher moisture content range. They increased with temperature such that the Arrhenius equation fits the data well, giving mean activation energies of 39,875 and 35,889 J/mole for the lower and higher moisture ranges, respectively. The calculated diffusion coefficient was approximately twice as high during desorption as during adsorption

Spinal Manipulation vs Sham Manipulation for Nonspecific Low Back Pain:A Systematic Review and Meta-Analysis

OBJECTIVE: The purpose of this systematic review was to identify and critically evaluate randomized controlled trials of spinal manipulation (SM) vs sham manipulation in the treatment of nonspecific low back pain. METHODS: Four electronic databases were searched from their inception to March 2015 to identify all relevant trials. Reference lists of retrieved articles were hand-searched. All data were extracted by 2 independent reviewers, and risk of bias was assessed using the Cochrane Back Review Group Risk of Bias tool. RESULTS: Nine randomized controlled trials were included in the systematic review, and 4 were found to be eligible for inclusion in a meta-analysis. Participants in the SM group had improved symptoms compared with participants receiving sham treatment (standardized mean difference = − 0.36; 95% confidence interval, − 0.59 to − 0.12). The majority of studies were of low risk of bias; however, several of the studies were small, the practitioner could not be blinded, and some studies did not conduct intention-to-treat analysis and had a high level of dropouts. CONCLUSION: There is some evidence that SM has specific treatment effects and is more effective at reducing nonspecific low back pain when compared with an effective sham intervention. However, given the small number of studies included in this analysis, we should be cautious of making strong inferences based on these results

Capabilities of the Impact Testing Facility at Marshall Space Flight Center

The test and analysis capabilities of the Impact Testing Facility at NASA's Marshall Space Flight Center are described. Nine different gun systems accommodate a wide range of projectile and target sizes and shapes at velocities from subsonic through hypersonic, to accomplish a broad range of ballistic and hypervelocity impact tests. These gun systems include ballistic and microballistic gas and powder guns, a two-stage light gas gun, and specialty guns for weather encounter studies. The ITF "rain gun" is the only hydrometeor impact gun known to be in existence in the United States that can provide single impact performance data with known raindrop sizes. Simulation of high velocity impact is available using the Smooth Particle Hydrodynamic Code. The Impact Testing Facility provides testing, custom test configuration design and fabrication, and analytical services for NASA, the Department of Defense, academic institutions, international space agencies, and private industry in a secure facility located at Marshall Space Flight Center, on the US Army's Redstone Arsenal in Huntsville, Alabama. This facility performs tests that are subject to International Traffic in Arms Regulations (ITAR) and DoD secret classified restrictions as well as proprietary and unrestricted tests for civil space agencies, academic institutions, and commercial aerospace and defense companies and their suppliers

Wall-associated kinase 1 (WAK1) is crosslinked in endomembranes, and transport to the cell surface requires correct cell-wall synthesis

The Arabidopsis thaliana wall-associated kinases (WAKs) bind to pectin with an extracellular domain and also contain a cytoplasmic protein kinase domain. WAKs are required for cell elongation and modulate sugar metabolism. This work shows that in leaf protoplasts a WAK1-GFP fusion protein accumulates in a cytoplasmic compartment that contains pectin. The WAK compartment contains markers for the Golgi, the site of pectin synthesis. The migration of WAK1-GFP to the cell surface is far slower than that of a cell surface receptor not associated with the cell wall, is influenced by the presence of fucose side chains on one or more unidentified molecules that might include pectin, and is dependent upon cellulose synthesis on the plasma membrane. WAK is crosslinked into a detergent-insoluble complex within the cytoplasmic compartment before it appears on the cell surface, and this is independent of fucose modification or cellulose synthesis. Thus, the assembly and crosslinking of WAKs may begin at an early stage within a cytoplasmic compartment rather than in the cell wall itself, and is coordinated with synthesis of surface cellulose

Modulated optical reflectance measurements on La2/3Sr1/3MnO3 thin films

The modulated optical reflectance (MOR) measurement technique was applied to colossal magnetoresistive materials, in particular, La2/3Sr1/3MnO3 (LSMO) thin films. The contactless measurement scheme is prospective for many applications spanning from materials characterization to new devices like reading heads for magnetically recorded media. A contrasted room temperature surface scan of a 100 microns wide 400 microns long bridge patterned into LSMO film provided preliminary information about the film homogeneity. Then the temperature was varied between 240 and 400 K, i.e. through the ferromagnetic to paramagnetic transition. A clear relation between the MOR signal measured as function of the temperature and the relative derivative of the resistivity up to the Curie temperature was observed. This relationship is fundamental for the MOR technique and its mechanism was explored in the particular case of LSMO. Analysis in the framework of the Drude model showed that, within certain conditions, the measured MOR signal changes are correlated to changes in the charge carrier concentration.Comment: 29 pages, accepted for publication in J. Appl. Phy

Pre-admission interventions to improve outcome after elective surgery-protocol for a systematic review

BACKGROUND: Poor physical health and fitness increases the risk of death and complications after major elective surgery. Pre-admission interventions to improve patients’ health and fitness (referred to as prehabilitation) may reduce postoperative complications, decrease the length of hospital stay and facilitate the patient’s recovery. We will conduct a systematic review of RCTs to examine the effectiveness of different types of prehabilitation interventions in improving the surgical outcomes of patients undergoing elective surgery. METHODS: This review will be conducted and reported according to the Cochrane and PRISMA reporting guidelines. MEDLINE, EMBASE, CENTRAL, CINAHL, PsycINFO, ISI Web of Science and clinical trial registers will be searched for any intervention administered before any elective surgery (including physical activity, nutritional, educational, psychological, clinical or multicomponent), which aims to improve postoperative outcomes. Reference lists of included studies will be searched, and grey literature including conference proceedings, theses, dissertations and preoperative assessment protocols will be examined. Study quality will be assessed using Cochrane’s risk of bias tool, and meta-analyses for trials that use similar interventions and report similar outcomes will be undertaken where possible. DISCUSSION: This systematic review will determine whether different types of interventions administered before elective surgery are effective in improving postoperative outcomes. It will also determine which components or combinations of components would form the most effective prehabilitation intervention. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD4201501919

Association, effects and validation of polymorphisms within the NCAPG - LCORL locus located on BTA6 with feed intake, gain, meat and carcass traits in beef cattle

<p>Abstract</p> <p>Background</p> <p>In a previously reported genome-wide association study based on a high-density bovine SNP genotyping array, 8 SNP were nominally associated (<it>P </it>≤ 0.003) with average daily gain (ADG) and 3 of these were also associated (<it>P </it>≤ 0.002) with average daily feed intake (ADFI) in a population of crossbred beef cattle. The SNP were clustered in a 570 kb region around 38 Mb on the draft sequence of bovine chromosome 6 (BTA6), an interval containing several positional and functional candidate genes including the bovine <it>LAP3, NCAPG</it>, and <it>LCORL </it>genes. The goal of the present study was to develop and examine additional markers in this region to optimize the ability to distinguish favorable alleles, with potential to identify functional variation.</p> <p>Results</p> <p>Animals from the original study were genotyped for 47 SNP within or near the gene boundaries of the three candidate genes. Sixteen markers in the <it>NCAPG-LCORL </it>locus displayed significant association with both ADFI and ADG even after stringent correction for multiple testing (P ≤ 005). These markers were evaluated for their effects on meat and carcass traits. The alleles associated with higher ADFI and ADG were also associated with higher hot carcass weight (HCW) and ribeye area (REA), and lower adjusted fat thickness (AFT). A reduced set of markers was genotyped on a separate, crossbred population including genetic contributions from 14 beef cattle breeds. Two of the markers located within the <it>LCORL </it>gene locus remained significant for ADG (P ≤ 0.04).</p> <p>Conclusions</p> <p>Several markers within the <it>NCAPG-LCORL </it>locus were significantly associated with feed intake and body weight gain phenotypes. These markers were also associated with HCW, REA and AFT suggesting that they are involved with lean growth and reduced fat deposition. Additionally, the two markers significant for ADG in the validation population of animals may be more robust for the prediction of ADG and possibly the correlated trait ADFI, across multiple breeds and populations of cattle.</p