920 research outputs found

    PUK18 RENAL TRANSPLANTATION VS HEMODIALYSIS-COST EFFECTIVENESS ANALYSIS

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    Wrangling environmental exposure data: guidance for getting the best information from your laboratory measurements.

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    BACKGROUND:Environmental health and exposure researchers can improve the quality and interpretation of their chemical measurement data, avoid spurious results, and improve analytical protocols for new chemicals by closely examining lab and field quality control (QC) data. Reporting QC data along with chemical measurements in biological and environmental samples allows readers to evaluate data quality and appropriate uses of the data (e.g., for comparison to other exposure studies, association with health outcomes, use in regulatory decision-making). However many studies do not adequately describe or interpret QC assessments in publications, leaving readers uncertain about the level of confidence in the reported data. One potential barrier to both QC implementation and reporting is that guidance on how to integrate and interpret QC assessments is often fragmented and difficult to find, with no centralized repository or summary. In addition, existing documents are typically written for regulatory scientists rather than environmental health researchers, who may have little or no experience in analytical chemistry. OBJECTIVES:We discuss approaches for implementing quality assurance/quality control (QA/QC) in environmental exposure measurement projects and describe our process for interpreting QC results and drawing conclusions about data validity. DISCUSSION:Our methods build upon existing guidance and years of practical experience collecting exposure data and analyzing it in collaboration with contract and university laboratories, as well as the Centers for Disease Control and Prevention. With real examples from our data, we demonstrate problems that would not have come to light had we not engaged with our QC data and incorporated field QC samples in our study design. Our approach focuses on descriptive analyses and data visualizations that have been compatible with diverse exposure studies with sample sizes ranging from tens to hundreds of samples. Future work could incorporate additional statistically grounded methods for larger datasets with more QC samples. CONCLUSIONS:This guidance, along with example table shells, graphics, and some sample R code, provides a useful set of tools for getting the best information from valuable environmental exposure datasets and enabling valid comparison and synthesis of exposure data across studies

    Kant a Christian? A Reply to Palmquist

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    Mysticism or Mediation: A Response to Gill

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    Decadal to seasonal variability of Arctic sea ice albedo

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    A controlling factor in the seasonal and climatological evolution of the sea ice cover is its albedo α\alpha. Here we analyze Arctic data from the Advanced Very High Resolution Radiometer (AVHRR) Polar Pathfinder and assess the seasonality and variability of broadband albedo from a 23 year daily record. We produce a histogram of daily albedo over ice covered regions in which the principal albedo transitions are seen; high albedo in late winter and spring, the onset of snow melt and melt pond formation in the summer, and fall freeze up. The bimodal late summer distribution demonstrates the combination of the poleward progression of the onset of melt with the coexistence of perennial bare ice with melt ponds and open water, which then merge to a broad peak at α\alpha \gtrsim 0.5. We find the interannual variability to be dominated by the low end of the α\alpha distribution, highlighting the controlling influence of the ice thickness distribution and large-scale ice edge dynamics. The statistics obtained provide a simple framework for model studies of albedo parameterizations and sensitivities.Comment: 4 pages, 4 figure
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