J-Block Triassic Well Performance & Reservoir Heterogeneity

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Influenza A nucleoprotein binding sites for antivirals: current research and future potential

This document is the Accepted Manuscript version of the following article: Andreas Kukol and Hershna Patel, ‘Influenza A nucleoprotein binding sites for antivirals: current research and future potential’, Future Biology, Vol 9(7): 625-627, July 2014. The version of record is available online at doi: 10.2217/fvl.14.45Peer reviewedFinal Accepted Versio

The Triplet Genetic Code had a Doublet Predecessor

Information theoretic analysis of genetic languages indicates that the naturally occurring 20 amino acids and the triplet genetic code arose by duplication of 10 amino acids of class-II and a doublet genetic code having codons NNY and anticodons $\overleftarrow{\rm GNN}$. Evidence for this scenario is presented based on the properties of aminoacyl-tRNA synthetases, amino acids and nucleotide bases.Comment: 10 pages (v2) Expanded to include additional features, including likely relation to the operational code of the tRNA-acceptor stem. Version to be published in Journal of Theoretical Biolog

An Investigation of the Efficacy of Curcumin for Treatment of Alzheimer\u27s Disease

Curcumin is the primary curcuminoid found in the rhizome of the turmeric plant (Curcuma longa), responsible for the spice’s distinctive yellow color. Research conducted within the past two decades suggests that the compound may be an effective treatment for Alzheimer’s disease, the most prevalent form of dementia affecting nearly 5.2 million Americans. This paper investigates the efficacy of curcumin as treatment for the pathogenesis and symptoms of Alzheimer’s. Research was conducted pertaining to the pathogenesis of Alzheimer’s, the in vitro applications of curcumin, the chemical properties of curcumin, and the in vivo clinical applications of curcumin. The pathogenesis of Alzheimer’s is defined by the aggregation of amyloid-beta plaques, dissociation of tau protein, propagation of reactive oxygen species, and neuroinflammation. Alzheimer’s is also characterized by symptoms of cognitive decline and memory loss. The physiochemical nature of curcumin enables it to interact with multiple biochemical pathways in the central nervous system (CNS), inhibiting the pathogenesis of the disease. In vitro applications of curcumin show much promise to this end. In vivo studies of curcumin on living subjects provide mixed results for the substance’s efficacy on symptoms and pathogenesis. Furthermore, the complex chemical properties of curcumin make drug development very difficult. Curcumin shows much promise in inhibiting the pathogenesis of Alzheimer’s, according to in vitro studies. However, the lack of definitive conclusions from in vivo applications and difficulty in overcoming curcumin’s complex chemical properties for drug development show that the substance cannot yet be designated as an effective treatment for the disease

Aereo and Internet Television: A Call to Save the Dukes (A La Carte)

If it looks like a duck, swims like a duck, and quacks like a duck, it is probably a duck. The most recent U.S. Supreme Court decision regarding the Copyright Act employed this “duck test” when determining that Aereo, an Internet content-streaming company, violated the Copyright Act by infringing on the copyrights of television broadcast networks. The Supreme Court ruled that Aereo\u27s Internet streaming services resembled cable television transmissions too closely. Therefore, by streaming copyrighted programming to its subscribers without the cable compulsory license, Aereo violated the Transmit Clause of the 1976 Copyright Act. Subsequently, Aereo used this Supreme Court decision to obtain a compulsory license from the Copyright Office but was denied. Forced back into litigation, Aereo filed for Chapter 11 Bankruptcy This Issue Brief describes Aereo’s technology, the litigation that followed, and the related precedent, and concludes that the district court should have granted Aereo a Section 111 Statutory License in line with the Supreme Court’s “duck test.” It considers the implications of the Court’s preliminary injunction against Aereo’s “a la carte” TV technology, what this means for the future of similar technological innovation, and the effects on consumers and competition

Weak Lensing with Radio Continuum Surveys

Weak gravitational lensing is a powerful probe of cosmology and has emerged as a key probe for the Dark Universe. Up till now this science has been conducted mainly at optical wavelengths. Current upgraded and future radio facilities will provide greatly improved data that will allow lensing measurements to be made at these longer wavelengths. In this proceedings I show how the larger facilities such as the SKA can produce game changing cosmological measurements even compared to future optical telescopes. I will also discuss how radio surveys can also provide unique ways in which some of the most problematic systematic errors can be mitigated through the extra information that can be provided in the form of polarisation and rotational velocity measurements. I will also demonstrate the advantages to having overlapping optical and radio weak lensing surveys and how their cross-correlation leads to a cleaner extraction of the cosmological information. Key to the realisation of the great promise of radio weak lensing is the suitable measurements of galaxy shapes in the radio data, either from images or from the visibility data. I shall end with a description of the key issues related to this matter and the radioGREAT challenge which has been proposed to address them.Comment: 9 pages, 2 figures, The Many Facets of Extragalactic Radio Surveys: Towards New Scientific Challenges, Bologna 20-23, 201

On how to Produce Entangled States Violating Bell's Inequalities in Quantum Theory

Feynman's path integrals provide a hidden variable description of quantum mechanics (and quantum field theories). The time evolution kernel is unitary in Minkowski time, but generically it becomes real and non-negative in Euclidean time. It follows that the entangled state correlations, that violate Bell's inequalities in Minkowski time, obey the inequalities in Euclidean time. This observation emphasises the link between violation of Bell's inequalities in quantum mechanics and unitarity of the theory. Search for an evolution kernel that cannot be conveniently made non-negative leads to effective interactions that violate time reversal invariance. Interactions giving rise to geometric phases in the effective description of the theory, such as the anomalous Wess-Zumino interactions, have this feature. I infer that they must be present in any set-up that produces entangled states violating Bell's inequalities. Such interactions would be a crucial ingredient in a quantum computer.Comment: 8 pages, two column revtex, arguments elaborated and strengthened, submitted to Physical Review

Scheduling a future air transport system

The scheduling of future timetables is an important driver for aircraft sales and design considerations in future aircraft. Airline companies seek to maximise their profits through capturing passenger demand through the quality of service they offer, within which timetabling plays an important role. In this study a hub and spoke system for medium haul travel is analysed, with particular reference to the time at which departing waves are set from the hub airport. Initially, an optimal wave time based only on the geography of the hub is considered. Subsequently, a model is developed which includes the constraints of market share and limited fleet size, and an example timetable produced. A final note is made about game theoretical aspects that might be considered in moving the work forward