Corporate social responsibility reporting in China: political, social and corporate influences

This paper explores the main drivers of CSR and its reporting for large Chinese listed companies, and identifies the key institutional pressures and stakeholder influences that shape CSR and its reporting. The data were collected through interviews with managers from large listed Chinese companies. Our findings reveal how the Chinese government uses social organisations and social intermediaries to facilitate and mediate CSR and its reporting to meet changing societal expectations across regions, while ensuring that companies remain responsive to the expectations of international stakeholders. We find that CSR and its reporting help companies gain political legitimacy domestically, while retaining their legitimacy in global markets. Companies co-operate with social organisations and social intermediaries actively and continuously. This helped companies secure political legitimacy with the government, while helping officials maintain their social legitimacy. Our findings on regional differences support the idea that relations between Chinese business and society have a fundamental effect on CSR and its reporting

Etat de la recherche sur le bois en Iran.

Après les ressources et consommation en bois, décrit les aspects de l'industrie du bois, l'enseignement, puis toute la filière des sciences du bois et de la recherche sur ce thème

Immunocompetent murine models for the study of glioblastoma immunotherapy.

Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in clinical outcomes are modest, in no small part due to tumor-induced immunosuppressive mechanisms that promote immune escape and immuno-resistance. Immunotherapeutic strategies aimed at bolstering the immune response while neutralizing immunosuppression will play a critical role in improving treatment outcomes for glioblastoma patients. In vivo murine models of glioma provide an invaluable resource to achieving that end, and their use is an essential part of the preclinical workup for novel therapeutics that need to be tested in animal models prior to testing experimental therapies in patients. In this article, we review five contemporary immunocompetent mouse models, GL261 (C57BL/6), GL26 (C57BL/6) CT-2A (C57BL/6), SMA-560 (VM/Dk), and 4C8 (B6D2F1), each of which offer a suitable platform for testing novel immunotherapeutic approaches

A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.

Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress. Here, we identify a chromatin-based system required for inducible aneuploidy in a human pathogen. Candida albicans utilizes chromosome missegregation to acquire tolerance to antifungal drugs and for nonmeiotic ploidy reduction after mating. We discovered that the ancestor of C. albicans and 2 related pathogens evolved a variant of histone 2A (H2A) that lacks the conserved phosphorylation site for kinetochore-associated Bub1 kinase, a key regulator of chromosome segregation. Using engineered strains, we show that the relative gene dosage of this variant versus canonical H2A controls the fidelity of chromosome segregation and the rate of acquisition of tolerance to antifungal drugs via aneuploidy. Furthermore, whole-genome chromatin precipitation analysis reveals that Centromere Protein A/ Centromeric Histone H3-like Protein (CENP-A/Cse4), a centromeric histone H3 variant that forms the platform of the eukaryotic kinetochore, is depleted from tetraploid-mating products relative to diploid parents and is virtually eliminated from cells exposed to aneuploidy-promoting cues. We conclude that genetically programmed and environmentally induced changes in chromatin can confer the capacity for enhanced evolvability via chromosome missegregation

Decay Modes of Unstable Strings in Plane-Wave String Field Theory

The cubic interaction vertex of light-cone string field theory in the plane-wave background has a simple effective form when considering states with only bosonic excitations. This simple effective interaction vertex is used in this paper to calculate the three string interaction matrix elements for states of arbitrary bosonic excitation and these results are used to examine certain decay modes on the mass-shell. It is shown that the matrix elements of one string to two string decays involving only bosonic excitations will vanish to all orders in 1/mu on the mass-shell when the number of excitations on the initial string is less than or equal to two, but in general will not vanish when the number of excitations is greater than two. Also, a truncated calculation of the mass-shell matrix elements for one string to three string decays of two excitation states is performed and suggests that these matrix elements do not vanish on the mass-shell. There is, however, a quantitative discrepancy between this last result and its (also non-vanishing) gauge theory prediction from the BMN correspondence.Comment: 11 pages; v2: references added; v3: normalization of interaction vertex and corresponding amplitudes changed by a factor of mu to reflect SFT normalization (must now divide by mu to compare with BMN dual gauge theory), and minor errors correcte

A Collaborative Planning Forecasting and Replenishment (CPFR) Maturity Model

This paper presents the development of a framework that organizations can use to assess their CPFR maturity. The proposed modeling framework identifies important functional and structural aspects of CPFR processes and formulates a method for evaluation on a variety of characteristics of CPFR. This paper uses a variant of multi-objective decision analysis to structure the framework into a hierarchical model for CPFR maturity assessment. Each area of the model was identified based on standardized, industry-accepted process definitions. Then, easy to answer questions were formulated to develop a multi-attribute assessment and scoring of capabilities. This model provides a structured representation of the CPFR process for maturity assessment and provides a path of progress for improving the state of CPFR within the  underperforming areas. The developed model can be used by engineering managers for assessing an on-going CPFR program across several areas and communicating the identified high impact improvement areas with various segments of the organization

Association between bilirubin and cardiovascular disease risk factors: using Mendelian randomization to assess causal inference

Background: Elevated serum bilirubin has been associated with reduced risk of cardiovascular disease (CVD). However, serum bilirubin is also related with several potential confounders related to CVD, such as obesity. Mendelian randomization has been proposed as a method to address challenges to validity from confounding and reverse causality. It utilizes genotype to estimate causal relationships between a gene product and physiological outcomes. In this report, we demonstrate its use in assessing direct causal relations between serum bilirubin levels and CVD risk factors, including obesity, cholesterol, measures of vascular function and blood pressure. Methods: Study subjects included 868 asymptomatic individuals. Study subjects were genotyped at the UGT1A1*28 locus, which is strongly associated with bilirubin levels. Results: Serum bilirubin levels were inversely associated with levels of several cardiovascular disease risk factors, including body mass index (p = 0.003), LDL (p = 0.0005) and total cholesterol (p = 0.0002). In contrast, UGT1A1*28 genotype, a known cause of elevated bilirubin levels, was not significantly associated with any of these traditional CVD risk factors. We did observe an association between genotype and brachial artery diameter (p = 0.003) and cold pressor reactivity (p = 0.01). Conclusions: Our findings imply that the observed association of serum bilirubin levels with body mass index and cholesterol are likely due to confounding and suggest that previously established CVD benefits of increased bilirubin may in part be mediated by the early regulation of vascular structure and reactivity

Transverse space-charge effects in the AGS booster during injection

We have analyzed the transverse motion for 200 MeV protons under strong space-charge conditions. We considered up to 5 /times/ 10/sup 12/ protons per bunch; for the assumed distribution this corresponds to a maximum tune shift of /minus/0.75. We utilized single particle tracking to study the motion in normalized phase space as a function of initial particle amplitude. Subsequent FFT analyses were used to obtain the fractional betatron tunes at different z values along the bunch. The motion shows x /minus/ y coupling due to the so-called Montague resonance (2Q/sub x//minus/2Q/sub y//equals/0). Perturbations arise when particles have tunes in the neighborhood of the 2Q /equals/ 9 half-integral resonances but losses do not occur. It appears that the motion is stabilized simply due to the strong amplitude dependence of the tunes. 2 refs., 5 figs., 4 tabs