A.L.I.C.E.: Performance as Research During a Pandemic

How is the continued COVID-19 pandemic interfering with the live art and entertainment industry? Embarking on performance as research and making art about world events while they occur instead of a reactive piece made after those events have ended, creates a particular kind of knowledge. The research and development process for the live, immersive performance, A.L.I.C.E., allowed for unique insights and experimentation with light, time, movement, text, costuming, context, alienation effects, liminality, mediation, auto-poetic feedback loops, technology, and the fourth wall. While the lessons learned about immersive performance are useful, just as important are observations about how we interact with technology, touch and other human beings during a devastating global health crisis

Understanding how Temperature influences European Starling’s Reproductive Success

Many habitats face fluctuating temperatures year round. The animals that live there are typically able to adjust their behaviors to match these conditions. When temperatures become too extreme, however, it could potentially start having a negative effect on the animal’s reproductive success. In birds, for example, severe climate can affect their eggs and nestlings due to nestlings lacking the ability to thermoregulate. The parents then have to bear the responsibility of thermoregulation for their young, through a behavior called incubation or brooding. European starlings (Sturnus vulgaris) are a species of birds common across the United States where both parents incubate their eggs and or brood their nestlings. In order to understand how the weather could impact these birds, we used nest cameras to record the behaviors of starling parents from March to June of 2020. We then used NOAA historical weather data to assess whether temperatures during the daytime shaped the number of eggs these starlings laid (clutch size). We also checked to see if weather temperatures effected the incubation and brooding behaviors of parents when they were keeping their nestlings warm (thermoregulation). We hypothesized that extreme temperatures (too warm or too cold) would results in less eggs at the nest, and more parental care from the parents

Grace Parker: 1918 & 2020 Pandemic Poster

Mixed-media digital collage 18 inches wide, 24 inches highhttps://ecommons.udayton.edu/stu_vad_covidcollage/1001/thumbnail.jp

What is the best approach for managing recurrent bacterial vaginosis?

The best way to prevent recurrent bacterial vaginosis is to treat the initial episode with the most effective regimen. Metronidazole (500 mg orally twice daily for 7 days) has the lowest recurrence rate among antimicrobial regimens for bacterial vaginosis (20% vs 34%-50% for other agents) (strength of recommendation [SOR]: A). Women should be treated if they are symptomatic (SOR: A), undergoing gynecologic surgery (SOR: B), or at risk for preterm labor (SOR: B)

An industrial museum in the heart of tartanism : the creation of the Nova Scotia Museum of Industry

152 leaves : colour illustrations, map ; 29 cmIncludes abstract and appendix.Includes bibliographical references (leaves 140-150).In the 1960s, Nova Scotia experienced a substantial increase in the number of museums across the province. Although most were cultural tourism sites, several were small industrial museums. The expansion of industrial museums peaked in the 1970s when the Nova Scotia Museum greenlighted the construction of the largest museum in Atlantic Canada – the Museum of Industry. A series of delays hindered the operations of the museum, and heated political debates led to the temporary closure of the Museum of Industry. This thesis details the origins of industrial heritage tourism in Nova Scotia and the extent to which it offers a romanticized narrative about the past. Further, it considers how and why the Museum of Industry became politically contentious in the 1990s. It also reflects on the place of the museum within the industrial community of Stellarton, and, more broadly, in Pictou County, the heart of Scottish tourism in Nova Scotia

Real Voices, Real Questions, Real Engagement: VCU Speaker Series

You come here for something more than schooling. You come here for deep education and deep education is about learning how to die so that you learn how to live because when you examine certain assumptions that you have, certain presuppositions that you’re holding on to, when you let them go, that’s a form of death. And there’s no growth, there’s no development, there’s no maturation without learning how to die and giving up certain dogma, giving up certain doctrine. - Cornel West, Ph.D., VCU Siegel Center, Fall 2015 VCU is a large, public, urban research university situated in the middle of a capital city. Its faculty, staff, student body, alumni, and the surrounding community are remarkably diverse as are the academic offerings. It is, and should be viewed as, the intellectual and cultural engine of the region. Our project proposes the creation of a large-scale, high-profile speaker series designed to highlight emerging trends and provide students, faculty, staff, alumni and the Richmond community with a forum for conversation. The speaker series will cover topics that are critically engaging, have national relevance, and introduce ideas that propel the next generation of leaders. In addition to a large speaking engagement, the speaker series will also incorporate other activities to cultivate interactions and build relationships such as classroom lectures, book signings, and a dinner through the development office. The speaker series will host at least one speaker annually, with the addition of a second speaker as the event builds momentum. At least one of the lectures will occur at the beginning of the traditional academic semester, allowing for the greatest opportunity for participation across VCU and Richmond. Internal support from VCU students, faculty, staff, and colleges will ensure that the project is connected to the mission, vision, goals, and pursuits of VCU. A speaker series committee will help sustain and coordinate efforts across the university and community. Committee members will include stakeholders that require buy-in and cooperation for activities that complement the speaker series (e.g., other lectures, panel discussions, classroom activities). A survey will be used to gain insights into topics and speakers of interest. The committee will review the survey responses in order to make informed decisions during the planning process. The ongoing presence of hosting influential speakers will allow VCU to emerge into the national spotlight as thought-leaders. This speaker series will serve many purposes. First, the series will serve to inspire VCU students, faculty, staff, and the Richmond. Through frank and open conversations attendees will be exposed to new concepts and ideas. Second, the series will unite the diverse groups that make up VCU and the Richmond community. The lecture series will expose attendees to new ideas and open doors for possible opportunities for collaboration through classroom and community engagement activities related to the topics discussed. Third, the series will serve as a cultural conduit, solidly connecting the VCU and Richmond communities around engaging ideas of importance. Opening a new market-place of ideas will ensure that the students of VCU interact with new information in exciting and transformative ways

Induction of Type I Interferon Signaling Determines the Relative Pathogenicity of Staphylococcus aureus Strains

The tremendous success of S. aureus as a human pathogen has been explained primarily by its array of virulence factors that enable the organism to evade host immunity. Perhaps equally important, but less well understood, is the importance of the intensity of the host response in determining the extent of pathology induced by S. aureus infection, particularly in the pathogenesis of pneumonia. We compared the pathogenesis of infection caused by two phylogenetically and epidemiologically distinct strains of S. aureus whose behavior in humans has been well characterized. Induction of the type I IFN cascade by strain 502A, due to a NOD2-IRF5 pathway, was the major factor in causing severe pneumonia and death in a murine model of pneumonia and was associated with autolysis and release of peptidogylcan. In contrast to USA300, 502A was readily eliminated from epithelial surfaces in vitro. Nonetheless, 502A caused significantly increased tissue damage due to the organisms that were able to invade systemically and trigger type I IFN responses, and this was ameliorated in Ifnar-/- mice. The success of USA300 to cause invasive infection appears to depend upon its resistance to eradication from epithelial surfaces, but not production of specific toxins. Our studies illustrate the important and highly variable role of type I IFN signaling within a species and suggest that targeted immunomodulation of specific innate immune signaling cascades may be useful to prevent the excessive morbidity associated with S. aureus pneumonia

SynthEx: a synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling

TCGA head and neck squamous cell carcinoma clinical information of tumors used in comparisons (n = 100). (XLSX 55 kb

An improved automated immunoassay for C-reactive protein on the Dimension® clinical chemistry system

Recent clinical data indicate that the measurement of the concentration of C-reactive protein (CRP) requires a higher sensitivity and wider dynamic range than most of the current methods can offer. Our goal was to develop a totally automated and highly sensitive CRP assay with an extended range on the Dimension® clinical chemistry system based on particle-enhanced turbidimetric-immunoassay (PETIA) technology. The improved method was optimized and compared to the Binding Site's radial immunodiffusion assay using disease state specimens to minimize interference. Assay performance was assessed on the Dimension® system in a 12-instrument inter-laboratory comparison study. A split-sample comparison (n = 622) was performed between the improved CRP method on the Dimension® system and the N Latex CRP mono method on the Behring Nephelometer, using a number of reagent and calibrator lots on multiple instruments. The method was also referenced to the standard material, CRM470, provided by the International Federation of Clinical Chemistry (IFCC). The improved CRP method was linear to 265.1mg/l with a detection limit between 0.2 and 0.5mg/l. The method detects antigen excess from the upper assay limit to 2000mg/l, thereby allowing users to retest the sample with dilution. Calibration was stable for 60 days. The within-run reproducibility (CV) was less than 5.1% and total reproducibility ranged from 1.1 to 6.7% between 3.3 and 265.4mg/l CRP. Linear regression analysis of the results on the improved Dimension® method (DM) versus the Behring Nephelometer (BN) yielded the following equation: DM = 0.99 × BN − 0.37; r = 0.992. Minimal interference was observed from sera of patients with elevated IgM, IgG and IgA. The recovery of the IFCC standard was within 100 ± 7 % across multiple lots of reagent and calibrator. The improved CRP method provided a sensitive, accurate and rapid approach to quantify CRP in serum and plasma on the Dimension® clinical chemistry system. The ability to detect antigen excess eliminated reporting falsely low results caused by the ‘prozone effect’