Evocative gene-environment correlation between genetic risk for schizophrenia and bullying victimization

Bullying exposure concerns over 10% of adolescents in Europe. Moreover, bullying victimization is heritable and victims are liable to psychotic symptoms, partly because of shared heritability with psychosis. The genetic component of bullying victimization has been proposed to involve the social reactions elicited by victims – a mechanism called “evocative gene-environment correlation”. We hypothesized that genetic risk for schizophrenia, a heritable disease also associated with social stress during childhood and adolescence, is related with social experiences during adolescence and is involved in the risk of developing psychotic symptoms. We studied 908 individuals of the TRAILS sample and found that 13-14-year-old adolescents with greater genetic risk for schizophrenia are more exposed to bullying assessed via peer nomination scores than their peers with lower genetic risk. Importantly, bullying victimization mediated the path from genetic risk to the frequency of psychotic symptoms about three years later. These findings provide evidence of a previously unreported form of gene-environment interplay that may be a mechanism of risk for psychosis and schizophrenia. To the extent that genetic risk translation into clinical symptoms is mediated by environmental risk factors, this evidence supports mental health prevention aimed at antagonizing bullying victimization in vulnerable individuals

performance and aging of opera bakelite rpcs

OPERA is an experiment dedicated to the observation of νμ into ντ oscillations through τ appearance on the CNGS beam. The experiment is composed by two identical super-modules, each with a target section (made of emulsion/lead bricks alternated to a scintillator Target Tracker) and a muon spectromter (instrumented with bakelite electrodes RPCs and drift tubes). The OPERA RPC system is composed of about 1000 RPCs for an instrumented area of 3000 m2. The RPCs are operated in streamer mode and flushed with the gas mixture Ar/C2H2F4/i−C4H10/SF6 = 75.4/20.0/4.0/0.6 at five refills/day in open flow. The present performance of the RPC system after six years of operation are presented. The aging status of the detector is also described

SHADOWS (Search for Hidden And Dark Objects With the SPS):Letter of Intent

We propose a new proton beam-dump experiment, SHADOWS, to search for a large variety of feebly-interacting particles possibly produced in the interactions of a 400 GeV proton beam with a high-Z material dump. SHADOWS will use the 400 GeV primary proton beam extracted from the CERN SPS currently serving the NA62 experiment in the CERN North area. SHADOWS will take data off-axis concurrently to the HIKE experiment when the P42 beam line is operated in beam-dump mode to accumulate up to 5 · 10^19 protons on target in 4 years of operation. This document describes the main achievements with respect to the Expression of Interest and represents an intermediate step towards the Proposal

The association between insight and depressive symptoms in schizophrenia: Undirected and Bayesian network analyses

Background. Greater levels of insight may be linked with depressive symptoms among patients with schizophrenia, however, it would be useful to characterize this association at symptom-level, in order to inform research on interventions. Methods. Data on depressive symptoms (Calgary Depression Scale for Schizophrenia) and insight (G12 item from the Positive and Negative Syndrome Scale) were obtained from 921 community-dwelling, clinically-stable individuals with a DSM-IV diagnosis of schizophrenia, recruited in a nationwide multicenter study. Network analysis was used to explore the most relevant connections between insight and depressive symptoms, including potential confounders in the model (neurocognitive and social-cognitive functioning, positive, negative and disorganization symptoms, extrapyramidal symptoms, hostility, internalized stigma, and perceived discrimination). Bayesian network analysis was used to estimate a directed acyclic graph (DAG) while investigating the most likely direction of the putative causal association between insight and depression. Results. After adjusting for confounders, better levels of insight were associated with greater self-depreciation, pathological guilt, morning depression and suicidal ideation. No difference in global network structure was detected for socioeconomic status, service engagement or illness severity. The DAG confirmed the presence of an association between greater insight and self-depreciation, suggesting the more probable causal direction was from insight to depressive symptoms. Conclusions. In schizophrenia, better levels of insight may cause self-depreciation and, possibly, other depressive symptoms. Person-centered and narrative psychotherapeutic approaches may be particularly fit to improve patient insight without dampening self-esteem

Insight in cognitive impairment assessed with the Cognitive Assessment Interview in a large sample of patients with schizophrenia

The Cognitive Assessment Interview (CAI) is an interview-based scale measuring cognitive impairment and its impact on functioning in subjects with schizophrenia (SCZ). The present study aimed at assessing, in a large sample of SCZ (n = 601), the agreement between patients and their informants on CAI ratings, to explore patients' insight in their cognitive deficits and its relationships with clinical and functional indices. Agreement between patient- and informant-based ratings was assessed by the Gwet's agreement coefficient. Predictors of insight in cognitive deficits were explored by stepwise multiple regression analyses. Patients reported lower severity of cognitive impairment vs. informants. A substantial to almost perfect agreement was observed between patients' and informants' ratings. Lower insight in cognitive deficits was associated to greater severity of neurocognitive impairment and positive symptoms, lower severity of depressive symptoms, and older age. Worse real-life functioning was associated to lower insight in cognitive deficit, worse neurocognitive performance, and worse functional capacity. Our findings indicate that the CAI is a valid co-primary measure with the interview to patients providing a reliable assessment of their cognitive deficits. In the absence of informants with good knowledge of the subject, the interview to the patient may represent a valid alternative

The surface Resistive Plate Counter: A new RPC based on resistive MPGD technology

The surface Resistive Plate Counter (sRPC) is a new RPC based on surface resistive electrodes realized with Diamond-Like-Carbon (DLC) sputtered on Apical\protect \relax \special {t4ht=®} foil. Exploiting the high rate resistive MPGD technology, detectors able to stand several tens of kHz/cm2 can be easily developed. The scalability of the technology allows the construction of detectors for large area applications at future high luminosity colliders