THE STRUCTURE AND THE GAS SENSETIVE PROPERTIES OF THE THIN FILMS OF ZINC OXIDE

The films were taken by the ion-beans method sputtering. It was shown that the samples have constant crystal structure and have good gas sensivity.Работа выполнена при поддержке Министерства образования и науки в рамках проектной части государственного задания

THE STRUCTURE AND THE ELECTRICAL PROPERTIES OF MULTILAYER SYSTEM In2O3-C

The films were taken by the ion-beans method sputtering. It is shown that the film In2O3-C has an X-ray amorphous structure with embedded In2O3 nanocrystallites. The films have a high gas sensitivity to hydrogen.Работа выполнена при поддержке Министерства образования и науки в рамках проектной части государственного задания (3.1867.2017/4.6)

The Tunka Experiment: Towards a 1-km^2 Cherenkov EAS Array in the Tunka Valley

The project of an EAS Cherenkov array in the Tunka valley/Siberia with an area of about 1 km^2 is presented. The new array will have a ten times bigger area than the existing Tunka-25 array and will permit a detailed study of the cosmic ray energy spectrum and the mass composition in the energy range from 10^15 to 10^18 eV.Comment: 3 pages, 2 figures, to be published in IJMP

Novel 1,4-Dihydropyridine Derivatives as Potential Agents with Analgesic Activity IN Orofacial Trigeminal Pain Test: Experimental Preclinical Randomized Trial

Background. In the majority of cases, contemporary pharmacological correction mainly focuses on the most effective analgesia. Therefore, the search for and research into new analgesic drugs are a priority in modern pharmacology.Objective — to establish the level of analgesic activity in eight novel heterocyclic compounds of 1,4-dihydropyridine derivatives synthesized in a classic test of orofacial trigeminal pain in animal experiments.Methods. An experimental preclinical randomized trial of the analgesic activity in 1,4-dihydropyridine derivatives was carried out. The experiment was conducted on 100 white male outbred rats in the laboratory of the Fundamental and Clinical Pharmacology Department, St. Luke Lugansk State Medical University, Lugansk People’s Republic. Novel 1,4-dihydropyridine derivatives were preliminarily investigated in a virtual biological screening by means of Swiss Target Prediction tool (Swiss Institute of Bioinformatics, Switzerland). The laboratory animals were divided into a control group (rats were exposed to acute pain syndrome by injecting 0.1 ml of 5% formalin solution into the vibrissae area without pharmacological correction), a comparison group (rats which received metamizole sodium (OOO Farmstandard) at a dose of 7 mg/kg 1.5 hour prior to acute pain syndrome modeling in the vibrissae area), and eight experimental groups (1.5 hours before formalin administration, novel 1,4-dihydropyridine derivatives under study at a dose of 5 mg/ kg were intragastrically injected). 10, 15 and 20 minutes after simulating acute pain, the number of scratching movements of the forelegs around orofacial region per minute was counted. Statistical processing of the results involved methods of mathematical statistics for quantitative variability and was carried out using Statistica 12.5 (IBM, USA).Results. Animals treated with 1,4-dihydropyridine derivatives d02-133 and d02-172 under the experimental conditions showed a significant (13–21 times) decrease in scratching movements frequency by the 10th minute of observation in comparison with the control group. By 15th minute, the analgesic activity of the cyanothioacetamide derivatives increased 14 and 11 times as compared to these indicators of the reference group. After 20 minutes, the analgesic activity of these compounds in terms of inhibiting nociceptive impulses, as compared to the control group, was also high, as the number of scratching movements in the vibrissae area in animals of these experimental groups was 8–9 times lower than in control group. The orofacial trigeminal pain test detected the most exhibited analgesic activity in novel cyanothioacetamide derivatives d02-139, d02-133, and d02-172, which appeared to be higher than that of metamizole sodium.Conclusion. It was found that novel original derivatives of 1,4-dihydropyridine showed a high degree of analgesic activity

Новая коронавирусная инфекция (COVID-19) у детей: клинико-лабораторные и диагностические аспекты

The study of a new coronavirus infection (COVID-19) in children is relevant and of interest for practical health care.Purpose: to identify the clinical and laboratory features of COVID-19 in the context of the six-month dynamics of the pandemic in children of the Orenburg region and to formulate recommendations for optimizing the diagnosis of this disease.Materials and methods. A retrospective analysis of 2661 results of detecting SARS-CoV-2 RNA (including 170 children) was carried out on the basis of the microbiological laboratory of the Orenburg State Medical University. Age and sex, structure of preliminary diagnoses, main clinical manifestations, frequency of testing and dynamics of the PCR threshold cycle in September 2020 and January 2021 were assessed.Results. The proportion of children examined in the Orenburg region from September 2020 to January 2021 increased from 4.6 ± 0.6% to 8.1 ± 0.7%. At the same time, the number of PCR + results also significantly increased from 5.0 ± 2.8% to 8.2 ± 2.6% (χ2 = 54.81; p = 0). The average age of children was 9—10 years old. The main reason for referral was pre-hospitalization screening not related to COVID-19. The proportion of PCR + results in this cohort was significantly lower in children than in adults. Among the clinically manifested forms in adults, the leading diagnosis was «pneumonia», and in children «ARVI». In childhood, a predominantly asymptomatic course of the disease was recorded. In children, unlike adults, PCR Ct values did not correlate with the severity and duration of the clinical manifestations of COVID-19.Conclusion. Due to the low diagnostic value of symptoms in children, it is more expedient to focus on epidemiological data and data from the results of laboratory examination methods. When interpreting the results of PCR diagnostics of COVID-19 for prognostic purposes, it is important to take into account the patient's age.Изучение новой коронавирусной инфекции (COVID-19) у детей актуально и представляет интерес для практического здравоохранения.Цель: выявить клинико-лабораторные особенности COVID-19 в разрезе полугодовой динамики пандемии у детей Оренбургского района и сформулировать рекомендации по оптимизации диагностики этого заболевания.Материалы и методы. Проведен ретроспективный анализ 2661 результата выявления РНК SARS-CoV-2 (из них 170 детей) на базе микробиологической лаборатории Оренбургского государственного медицинского университета. Оценивались возраст и пол, структура предварительных диагнозов, основные клинические проявления, частота тестирования и динамика порогового цикла ПЦР в сентябре 2020 года и январе 2021 года.Результаты. Доля обследованных детей в Оренбургском районе с сентября 2020 года по январь 2021 года увеличилась с 4,6 ± 0,6% до 8,1 ± 0,7%. При этом количество ПЦР+ результатов так же достоверно увеличилось с 5,0 ± 2,8% до 8,2 ± 2,6% (χ2 =54,81; р = 0). Средний возраст детей составил 9-10 лет. Основной причиной направления было обследование перед госпитализацией, не связанной с COVID-19. Доля ПЦР+ результатов в данной когорте у детей была значительно меньше, чем у взрослых. Среди клинически проявленных форм у взрослых лидировал диагноз «пневмония», а у детей «ОРВИ». В детском возрасте регистрировалось преимущественно малосимптомное течение болезни. У детей, в отличие от взрослых, значения Ct ПЦР не коррелировали с тяжестью и продолжительностью клинических проявлений COVID-19.Заключение. Ввиду малой диагностической ценности симптомов у детей целесообразнее ориентироваться на эпидемиологические данные и данные результатов лабораторных методов обследования. При интерпретации результатов ПЦР диагностики COVID-19 с прогностической целью важно учитывать возраст пациента

INFLUENCE OF AMORPHOUS CARBON ON THE STRUCTURE AND ELECTRICAL PROPERTIES OF (ZnO/С)81 THIN FILMS

(ZnO/C)81 thin films was prepared by ion beam sputtering. Analysis of the structure for resulting thin films showed that the ZnO layers are in the nanocrystalline state, and the carbon layers are in amorphous state. By adding amorphous carbon, the process of recrystallization in (ZnO/C)81 thin films was reduced in comparison with ZnO films (grain size increase).Работа выполнена при поддержке Министерства образования и науки в рамках проектной части государственного задания (проект № 3.1867.2017/4.6)

Study of anti-inflammatory and antinociceptive properties of new derivatives of condensed 3-aminothieno[2,3-b]pyridines and 1,4-dihydropyridines

Background. α-сyanothioacetamide derivatives are promising targets for the search for effective and safe antinociceptive agents with antipyretic and antiexudative activity. The aim. To conduct in vivo experimental study of anti-inflammatory and analgesic effects of new thienopyridines and 1,4-dihydropyridines derivatives. Materials and methods. The synthesized cyanothioacetamide derivatives were subjected to virtual bioscreening using Swiss Target Prediction online service. 140  laboratory rats were randomly distributed into intact and control (dextran edema) groups, reference groups (acetylsalicylic acid and  nimesulide) and ten experimental groups for the investigated derivatives of thieno[2,3-b]pyridine and 1,4-dihydropyridine. The anti-inflammatory activity of the compounds at a dose of 5 mg/kg was evaluated by modeling acute dextran edema of rat paw. Determination of analgesic activity was carried out in the hotplate analgesic assay on 130 rats in comparison with sodium metamizole. Results. 1,4-dihydropyridines AZ331 and AZ420, as well as thienopyridine derivative AZ023 were determined to have strong anti-inflammatory activity (2.5 times more effective than nimesulide and 2.2 times more effective than acetylsalicylic acid). Compounds AZ023, AZ331 and AZ383 showed pronounced analgesic activity. The time of stay on the heated plate for rats of experimental groups that were fed with AZ331 and AZ383 for prophylactic purpose was respectively 9.56 and 9.93 times more than the same index in the reference group. The animals receiving AZ023 were characterized by an increase in the latent reaction time up to 241.2 seconds, which is 14.53 times higher than that in the rats received sodium metamizole. Conclusion. New thienopyridine and 1,4-dihydropyridine derivatives with high antiinflammatory and analgesic activity were synthesized and studied; they were recognized as promising targets for further preclinical studies

The advancement of fixation of maxillary dentures in full dental series using copyright methods

The success of orthopedic treatment with dentures mostly depends on the degree of their fixation on the jaw. It is necessary for the basis of maxillary prosthesis not only to reflect the mucous membrane accurately, but also to create it's compression across the back edge. In case of failure of these conditions, denture easily releases during the nibble of food lump, often appears a heightened emetic reflex, injures the tongue and occurs the delay and the accumulation of food in this area, which makes it difficult to use. The proposed by the authors methodology allows to reduce the deformation basis of maxillary prosthesis during the polymerization of plastic, what provides a high degree of conformity of it's basis with prosthetic bed and ,as a consequence, the conservation of fringe lock valve (0-0,15 mm uniform gap across the back edge).Успех ортопедического лечения съемными протезами во многом зависит от степени их фиксации на челюстях. Необходимо, чтобы базис верхнечелюстного протеза не только точно соответствовал слизистой оболочке, но и создавал ее компрессию по всему заднему краю. При несоблюдении этих условий, съемный протез легко сбрасывается во время откусывания пищевого комка, часто появляется усиленный рвотный рефлекс, травмируется язык и происходит задержка и накопление пищи в данной области, что затрудняет его использование. Предложенная авторами методика позволяет снизить деформацию базиса верхнечелюстного протеза в процессе полимеризации пластмассы, что обеспечивает высокую степень соответствия его базиса протезному ложу и как следствие сохранение краевого замыкающего клапана (равномерный зазор 0-0,15 мм по всему заднему краю)