Altered excitation-contraction coupling in human chronic atrial fibrillation

This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory period, depressed intracellular Ca<sup>2+</sup> transient, and reduced myocyte contractility. Here we summarize the current knowledge of the ionic bases underlying these changes. Understanding the molecular mechanisms of excitation-contraction-coupling remodeling in the fibrillating human atria is important to identify new potential targets for AF therapy

Disentangling protein and lipid interactions that control a molecular switch in photosynthetic light harvesting

In the photosynthetic apparatus of plants and algae, the major Light-Harvesting Complexes (LHCII) collect excitations and funnel these to the photosynthetic reaction center where charge separation takes place. In excess light conditions, remodeling of the photosynthetic membrane and protein conformational changes produces a photoprotective state in which excitations are rapidly quenched to avoid photodamage. The quenched states are associated with protein aggregation, however the LHCII complexes are also proposed to have an intrinsic capacity to shift between light harvesting and fluorescence-quenched conformational states. To disentangle the effects of protein-protein and protein-lipid interactions on the LHCII photoprotective switch, we compared the structural and fluorescent properties of LHCII lipid nanodiscs and proteoliposomes with very low protein -to-lipid ratios. We demonstrate that LHCII proteins adapta fully fluorescent state in nanodiscs and in proteoliposomes with highly diluted protein densities. Increasing the protein density induces a transition into a mildly-quenched state that reaches a plateau at a molar protein-to-lipid ratio of 0.001 and has a fluorescence yield reminiscent of the light-harvesting state in vivo. The low onset for quenching strongly suggests that LHCII-LHCII attractive interactions occur inside membranes. The transition at low protein densities does not involve strong changes in the excitonic circular-dichroism spectrum and is distinct from a transition occurring at very high protein densities that comprises strong fluorescence quenching and circular-dichroism spectral changes involving chlorophyll 611 and 612, correlating with proposed quencher sites of the photoprotective mechanism

Dynamics of Passive-Scalar Turbulence

We present the first study of the dynamic scaling or multiscaling of passive-scalar and passive-vector turbulence. For the Kraichnan version of passive-scalar and passive-vector turbulence we show analytically, in both Eulerian and quasi-Lagrangian frameworks, that simple dynamic scaling is obtained but with different dynamic exponents. By developing the multifractal model we show that dynamic multiscaling occurs in passive-scalar turbulence only if the advecting velocity field is itself multifractal. We substantiate our results by detailed numerical simulations in shell models of passive-scalar advection.Comment: published versio

Random spread on the family of small-world networks

We present the analytical and numerical results of a random walk on the family of small-world graphs. The average access time shows a crossover from the regular to random behavior with increasing distance from the starting point of the random walk. We introduce an {\em independent step approximation}, which enables us to obtain analytic results for the average access time. We observe a scaling relation for the average access time in the degree of the nodes. The behavior of average access time as a function of $p$, shows striking similarity with that of the {\em characteristic length} of the graph. This observation may have important applications in routing and switching in networks with large number of nodes.Comment: RevTeX4 file with 6 figure

A simple model for dynamic heterogeneity in glass-forming liquids

Liquids near the glass transition exhibit dynamical heterogeneity, i.e. local relaxation rates fluctuate strongly over space and time. Here we introduce a simple continuum model that allows for quantitative predictions for the correlators describing these fluctuations. We find remarkable agreement of the model predictions for the dynamic susceptibility $\chi_4(t)$ with numerical results for a binary hard-sphere (HARD) liquid and for a Kob-Andersen Lennard-Jones (KALJ) mixture. We explain why the existence and position of the peak of $\chi_4(t)$ provides no information about the lifetime $\tau_{\rm ex}$ of the heterogeneities. We show that $\chi_4(t)$ depends weakly on $\tau_{\rm ex}$, but find a way to use this weak dependence to estimate $\tau_{\rm ex}$ from $\chi_4(t)$.Comment: Main text: 5 pages, 3 figures. Supplemental material: 2 pages, 1 figur

The bli regulon - a network of blue light inducible genes of N. crassa

Several physiological responses of N. crassa are observed when this fungus is exposed to blue light. Here, we do not intend to make a comprehensive list of all the light effects observed so far in N. crassa (for a review, see Degli Innocenti and Russo 1984. In Blue Light Effects in Biological Systems ed. H. Senger, Springer-Verlag. pp 213-219.), but point out only the underlying themes. First, the time interval between the light stimulus and the observed response can be very different, and ranges from a few minutes to several hours - or even days - depending on the nature of the physiological response in question

Characterization and control of small-world networks

Recently Watts and Strogatz have given an interesting model of small-world networks. Here we concretise the concept of a ``far away'' connection in a network by defining a {\it far edge}. Our definition is algorithmic and independent of underlying topology of the network. We show that it is possible to control spread of an epidemic by using the knowledge of far edges. We also suggest a model for better advertisement using the far edges. Our findings indicate that the number of far edges can be a good intrinsic parameter to characterize small-world phenomena.Comment: 9 pages and 6 figure

Evidence for Excimer Photoexcitations in an Ordered {\pi}-Conjugated Polymer Film

We report pressure-dependent transient picosecond and continuous-wave photomodulation studies of disordered and ordered films of 2-methoxy-5-(2-ethylhexyloxy) poly(para-phenylenevinylene). Photoinduced absorption (PA) bands in the disordered film exhibit very weak pressure dependence and are assigned to intrachain excitons and polarons. In contrast, the ordered film exhibits two additional transient PA bands in the midinfrared that blueshift dramatically with pressure. Based on high-order configuration interaction calculations we ascribe the PA bands in the ordered film to excimers. Our work brings insight to the exciton binding energy in ordered films versus disordered films and solutions. The reduced exciton binding energy in ordered films is due to new energy states appearing below the continuum band threshold of the single strand.Comment: 5.5 pages, 5 figure

Edge wetting of an Ising three-dimensional system

The effect of edge on wetting and layering transitions of a three-dimensional spin-1/2 Ising model is investigated, in the presence of longitudinal and surface magnetic fields, using mean field (MF) theory and Monte Carlo (MC) simulations. For T=0, the ground state phase diagram shows that there exist only three allowed transitions, namely: surface and bulk transition, surface transition and bulk transition. However, there exist a surface intra-layering temperature $T_{L}^{s}$, above which the surface and the intra-layering surface transitions occur. While the bulk layering and intra-layering transitions appear above an other finite temperature $T_{L}^{b} (\ge T_{L}^{s})$. These surface and bulk intra-layering transitions are not seen in the perfect surfaces case. Numerical values of $T_{L}^{s}$ and $T_{L}^{b}$, computed by Monte Carlo method are found to be smaller than those obtained using mean field theory. However, the results predicted by the two methods become similar, and are exactly those given by the ground state phase diagram, for very low temperatures. On the other hand, the behavior of the local magnetizations as a function of the external magnetic field, shows that the transitions are of the first order type. $T_{L}^{s}$ and $T_{L}^{b}$ decrease when increasing the system size and/or the surface magnetic field. In particular, $T_{L}^{b}$ reaches the wetting temperature $T_{w}$ for sufficiently large system sizes.Comment: 11 Pages latex, 12 Figures P