Operational Trans-Resistance Amplifier Based Tunable Wave Active Filter

In this paper, Operational Trans-Resistance Amplifier (OTRA) based wave active filter structures are presented. They are flexible and modular, making them suitable to implement higher order filters. The circuits implement the resistors using matched transistors, operating in linear region, making them well suited for IC fabrication. They are insensitive to parasitic input capacitances and input resistances due to the internally grounded input terminals of OTRA. As an application, a doubly terminated third order Butterworth low pass filter has been implemented, by substituting OTRA based wave equivalents of passive elements. PSPICE simulations are given to verify the theoretical analysis

X-ray Intraday Variability of Five TeV Blazars with NuSTAR

We have examined 40 NuSTAR light curves (LCs) of five TeV emitting high synchrotron peaked blazars: 1ES 0229+200, Mrk 421, Mrk 501, 1ES 1959+650 and PKS 2155-304. Four of the blazars showed intraday variability in the NuSTAR energy range of 3-79 keV. Using an auto correlation function analysis we searched for intraday variability timescales in these LCs and found indications of several between 2.5 and 32.8 ks in eight LCs of Mrk 421, a timescale around 8.0 ks for one LC of Mrk 501, and timescales of 29.6 ks and 57.4 ks in two LCs of PKS 2155-304. The other two blazars' LCs do not show any evidence for intraday variability timescales shorter than the lengths of those observations, however, the data was both sparser and noisier, for them. We found positive correlations with zero lag between soft (3-10 keV) and hard (10-79 keV) bands for most of the LCs, indicating that their emissions originate from the same electron population. We examined spectral variability using a hardness ratio analysis and noticed a general "harder-when-brighter" behavior. The 22 LCs of Mrk 421 observed between July 2012 and April 2013 show that this source was in a quiescent state for an extended period of time and then underwent an unprecedented double peaked outburst while monitored on a daily basis during 10 - 16 April 2013. We briefly discuss models capable of explaining these blazar emissions.Comment: 21 pages, 4 figures, 4 tables, Accepted for Publication in Ap

An efficient high-order Nystr\"om scheme for acoustic scattering by inhomogeneous penetrable media with discontinuous material interface

This text proposes a fast, rapidly convergent Nystr\"{o}m method for the solution of the Lippmann-Schwinger integral equation that mathematically models the scattering of time-harmonic acoustic waves by inhomogeneous obstacles, while allowing the material properties to jump across the interface. The method works with overlapping coordinate charts as a description of the given scatterer. In particular, it employs "partitions of unity" to simplify the implementation of high-order quadratures along with suitable changes of parametric variables to analytically resolve the singularities present in the integral operator to achieve desired accuracies in approximations. To deal with the discontinuous material interface in a high-order manner, a specialized quadrature is used in the boundary region. The approach further utilizes an FFT based strategy that uses equivalent source approximations to accelerate the evaluation of large number of interactions that arise in the approximation of the volumetric integral operator and thus achieves a reduced computational complexity of $O(N \log N)$ for an $N$-point discretization. A detailed discussion on the solution methodology along with a variety of numerical experiments to exemplify its performance in terms of both speed and accuracy are presented in this paper

Mutational signatures in colon cancer.

ObjectiveRecently, many tumor sequencing studies have inferred and reported on mutational signatures, short nucleotide patterns at which particular somatic base substitutions appear more often. A number of signatures reflect biological processes in the patient and factors associated with cancer risk. Our goal is to infer mutational signatures appearing in colon cancer, a cancer for which environmental risk factors vary by cancer subtype, and compare the signatures to those in adult stem cells from normal colon. We also compare the mutational signatures to others in the literature.ResultsWe apply a probabilistic mutation signature model to somatic mutations previously reported for six adult normal colon stem cells and 431 colon adenocarcinomas. We infer six mutational signatures in colon cancer, four being specific to tumors with hypermutation. Just two signatures explained the majority of mutations in the small number of normal aging colon samples. All six signatures are independently identified in a series of 295 Chinese colorectal cancers

Concentration Gradient, Diffusion, and Flow Through Open Porous Medium Near Percolation Threshold via Computer Simulations

The interacting lattice gas model is used to simulate fluid flow through an open percolating porous medium with the fluid entering at the source-end and leaving from the opposite end. The shape of the steady-state concentration profile and therefore the gradient field depends on the is found to scale with the porosity according to porosity p. The root mean square (rms) displacements of fluid and its constituents (tracers) show a drift power-law behavior, in the asymptotic regime. The flux current density is found to scale with the porosity according to an exponent near 1.7.Comment: 8 figure