Hōmai te Waiora ki Ahau: te ara whakamua - towards the establishment of construct validity

Hōmai te Waiora ki Ahau: te ara whakamua, is about the development of a tool to measure psychological wellbeing among Māori. Why is it relevant? Because a quick look at the June 2002 edition of New Zealand’s Journal of Psychology will show you that the wellbeing measures being used in this country are not responsive to the needs of Māori, are not based on Māori concepts or Constructs, do not facilitate Māori participation in te ao Māori and do not provide pathways through which Māori can develop a positive Māori identity. It is highly unlikely that the tools which psychologists use to measure wellbeing among Māori will help Māori to experience whānau ora and that, as we all know, is the paramount health objective for Māori (Ministry of Health, 2002). In this regard, it would seem that the powers that be in psychology are failing to meet their Treaty obligations to Māori. Therefore, Hōmai te Waiora ki Ahau simply aims to assist change. This presentation will briefly describe the context of the development of this measure, the methodologies used to develop this tool, the outcomes of a small pilot-study, and current challenges and future directions for Hōmai te Waiora ki Ahau

Identification of synthetic chemical compound inhibitors of Pseudomonas aeruginosa protein synthesis and the development of lead series

Pseudomonas aeruginosa is a ubiquitous Gram-negative bacteria and a primary cause of nosocomial infections. An aminoacylation/translation (A/T) assay was developed using P. aeruginosa components to perform poly(U) mRNA directed protein synthesis. Using scintillation proximity assay (SPA) technology a high-throughput screening (HTS) platform was developed. A synthetic chemical compound library (\u3e900) was screened, 36 hit compounds were identified and molecular targets were determined. Compounds were analyzed for enzymatic inhibition (IC50) and inhibition of bacterial cultures (MIC). Time-kill studies determined bacterial growth to be bacteriostatic or bactericidal in the presence of inhibitor. Mechanism of action, effects on eukaryotic cytosolic and mitochondrial protein synthesis were determined. Cytotoxicity using a mammalian cell line and global mode of inhibition was determined. One compound was evaluated for the ability to generate spontaneous resistant mutants or develop resistance after serial passage

Star formation and accretion in the circumnuclear disks of active galaxies

We explore the evolution of supermassive black holes (SMBH) centered in a circumnuclear disk (CND) as a function of the mass supply from the host galaxy and considering different star formation laws, which may give rise to a self-regulation via the injection of supernova-driven turbulence. A system of equations describing star formation, black hole accretion and angular momentum transport was solved for an axisymmetric disk in which the gravitational potential includes contributions from the black hole, the disk and the hosting galaxy. Our model extends the framework provided by Kawakatu et al. (2008) by separately considering the inner and outer part of the disk, and by introducing a potentially non-linear dependence of the star formation rate on the gas surface density and the turbulent velocity. The star formation recipes are calibrated using observational data for NGC 1097, while the accretion model is based on turbulent viscosity as a source of angular momentum transport in a thin viscous accretion disk. We find that current data provide no strong constraint on the star formation recipe, and can in particular not distinguish between models entirely regulated by the surface density, and models including a dependence on the turbulent velocity. The evolution of the black hole mass, on the other hand, strongly depends on the applied star formation law, as well as the mass supply from the host galaxy. We suggest to explore the star formation process in local AGN with high-resolution ALMA observations to break the degeneracy between different star formation models.Comment: 13 pages, 15 figures, 6 tables, accepted at A&

Murine Warriors or Worriers: The Saga of Comt1, B2 SINE Elements, and the Future of Translational Genetics

Catechol-O-methyltransferase (COMT) is an extremely well characterized enzyme that degrades catecholamines. A common coding polymorphism (rs4680; Val158Met) in the human COMT gene has been associated with a diverse array of phenotypes including personality, cognition, pain sensitivity, and risk for psychiatric disorders (Tunbridg

State Dependence of Stimulus-Induced Variability Tuning in Macaque MT

Behavioral states marked by varying levels of arousal and attention modulate some properties of cortical responses (e.g. average firing rates or pairwise correlations), yet it is not fully understood what drives these response changes and how they might affect downstream stimulus decoding. Here we show that changes in state modulate the tuning of response variance-to-mean ratios (Fano factors) in a fashion that is neither predicted by a Poisson spiking model nor changes in the mean firing rate, with a substantial effect on stimulus discriminability. We recorded motion-sensitive neurons in middle temporal cortex (MT) in two states: alert fixation and light, opioid anesthesia. Anesthesia tended to lower average spike counts, without decreasing trial-to-trial variability compared to the alert state. Under anesthesia, within-trial fluctuations in excitability were correlated over longer time scales compared to the alert state, creating supra-Poisson Fano factors. In contrast, alert-state MT neurons have higher mean firing rates and largely sub-Poisson variability that is stimulus-dependent and cannot be explained by firing rate differences alone. The absence of such stimulus-induced variability tuning in the anesthetized state suggests different sources of variability between states. A simple model explains state-dependent shifts in the distribution of observed Fano factors via a suppression in the variance of gain fluctuations in the alert state. A population model with stimulus-induced variability tuning and behaviorally constrained information-limiting correlations explores the potential enhancement in stimulus discriminability by the cortical population in the alert state.Comment: 36 pages, 18 figure