Peri-implant diseases and metabolic syndrome components: a systematic review

OBJECTIVE: Metabolic syndrome (MetS) is defined as a spectrum of conditions associated with an increased risk of developing CVD and type 2 diabetes. MetS include: hyperglycemia, hypertension, visceral obesity, dyslipidemia with elevated values of triglycerides (TG) and low levels of HDL. The aim of this review is to provide current knowledge of the relationship between MetS, its components and peri-implant diseases. MATERIALS AND METHODS: An electronic literature search was conducted in the English language in several databases. The Newcastle-Ottawa Scale was used for quality assessment of cohort and cross-sectional studies; while systematic reviews were evaluated through AMSTAR; results were reported according to the PRISMA Statement. RESULTS: A total of 272 records were identified through database searching, six studies were included for qualitative analysis. No study directly related to MetS was found, there was inconsistent and controversial evidence regarding association with cardiovascular disease. A higher risk of peri-implantitis was detected in people with hyperglycemia. CONCLUSIONS: Future research should be orientated in assessing the risk of peri-implant diseases, evaluating patient's therapeutic response, analyzing directionality of the relationship between MetS, its components and biologic implant complications. Few studies have investigated the possible relationship between systemic conditions and peri-implant diseases. The aim of this review is to present, in a systematic manner, current evidence and knowledge regarding possible association between cardiovascular disease and implant biologic complications. Out of the one-hundred-eighty-nine studies screened, just five studies were selected for qualitative analysis: three cohort studies (one prospective and two retrospectives) and two cross-sectional studies. According to their results, there is inconsistent and controversial evidence regarding association of cardiovascular disease and implant biologic complications. Future research should be orientated in conducting longitudinal studies, evaluating patients affected by cardiovascular disease rehabilitated with dental implants

How to exploit the Social Internet of Things: Query Generation Model and Device Profiles’ Dataset

The future Internet of Things (IoT) will be characterized by an increasing number of object-to-object interactions for the implementation of distributed applications running in smart environments. The Social IoT (SIoT) is one of the possible paradigms that is proposed to make the objects’ interactions easier by facilitating the search of services and the management of objects’ trustworthiness. In this scenario, we address the issue of modeling the queries that are generated by the objects when fulfilling applications’ requests that could be provided by any of the peers in the SIoT. To this, the defined model takes into account the objects’ major features in terms of typology and associated functionalities, and the characteristics of the applications. We have then generated a dataset, by extracting objects’ information and positions from the city of Santander in Spain. We have classified all the available devices according to the FIWARE Data Models, so as to enable the portability of the dataset among different platforms. The dataset and the proposed query generation model are made available to the research community to study the navigability of the SIoT network, with an application also to other IoT networks. Experimental analyses have also been conducted, which give some key insights on the impact of the query model parameters on the average number of hops needed for each search

Amplitude analysis and the nature of the Zc(3900)

The microscopic nature of the XYZ states remains an unsettled topic. We show how a thorough amplitude analysis of the data can help constraining models of these states. Specifically, we consider the case of the Zc(3900) peak and discuss possible scenarios of a QCD state, virtual state, or a kinematical enhancement. We conclude that current data are not precise enough to distinguish between these hypotheses, however, the method we propose, when applied to the forthcoming high-statistics measurements should shed light on the nature of these exotic enhancements.Comment: 14 pages, 10 figures, 3 tables. Version accepted for publication on Phys.Lett.

Mechanical properties of several newly produced RAFM steels with Tungsten content in the range of 2 wt%

The contribution of ENEA together with Rina-CSM to the Eurofusion programme \u201cWPMAT-Advanced Seels\u201d deals with the development of innovative RAFM steels able to withstand the critical temperatures typical of the different operational environments foreseen for the blanket of the first DEMO reactor. The optimization of the chemical composition and the Thermo Mechanical Treatment for these materials should be done according to the blanket operating temperatures that are related to two possible working conditions: the WCLL-BB (Water Cooled Lead Lithium Breeding Blanket) or the H(D)CLL-BB (Helium (Dual) Cooled Lead Lithium Breeding Blanket). On the one hand the \u201cwater-cooling\u201d option implies a minimum irradiation temperature for the blanket material in the range of 280\u2013350 \ub0C. On the other hand, the \u201chelium-cooled\u201d and the \u201cdual-coolant\u201d solutions imply an operating temperature for the blanket material in the range of 650 \ub0C. Therefore in the first case the target is the improvement of the toughness of the martensitic alloys; whilst concerning the second scenario the target is the development of more creep resistant martensitic steels, suitable to tolerate such a high operating temperature. In both the cases the Tungsten content plays a key role, both in terms of solid solution hardening and influence on the DBTT. Two alloys aimed at fulfilling the specifications for the two DEMO operating conditions, both with increased Tungsten content respect to Eurofer, have been produced and characterized. The mechanical properties of these two alloys are hereby reported and discussed

Pilomatrix carcinoma: a rare cutaneous adnexal tumor

Pilomatrix carcinoma is a rare tumor that is generally not diagnosed clinically. An 80-year-old man presented with a 5-month history of rapidly growing nodule of the submandibular area. Histological examination revealed a pilomatrix carcinoma, an aggressive malignancy with metastatic potential

On the η\eta and η′\eta' Photoproduction Beam Asymmetry at High Energies

We show that, in the Regge limit, beam asymmetries in $\eta$ and $\eta'$ photoproduction are sensitive to hidden strangeness components. Under reasonable assumptions about the couplings we estimate the contribution of the $\phi$ Regge pole, which is expected to be the dominant hidden strangeness contribution. The ratio of the asymmetries in $\eta'$ and $\eta$ production is estimated to be close to unity in the forward region $0 < -t/\text{GeV}^2 \leq 1$ at the photon energy $E_\text{lab} = 9$~GeV, relevant for the upcoming measurements at Jefferson Lab.Comment: 9 pages, 4 figure

Exclusive tensor meson photoproduction

We study tensor meson photoproduction outside of the resonance region, at beam energies of few GeVs. We build a model based on Regge theory that includes the leading vector and axial exchanges. We consider two determinations of the unknown helicity couplings, and fit to the recent a2 photoproduction data from CLAS. Both choices give a similar description of the a2 cross section, but result in different predictions for the parity asymmetries and the f2 photoproduction cross section. We conclude that new measurements of f2 photoproduction in the forward region are needed to pin down the correct production mechanism. We also extend our predictions to the 8.5 GeV beam energy, where current experiments are running.Comment: 13 pages, 7 figures, 3 tables. Version accepted for publication on Phys.Rev.

Structure of Pion Photoproduction Amplitudes

We derive and apply the finite energy sum rules to pion photoproduction. We evaluate the low energy part of the sum rules using several state-of-the-art models. We show how the differences in the low energy side of the sum rules might originate from different quantum number assignments of baryon resonances. We interpret the observed features in the low energy side of the sum rules with the expectation from Regge theory. Finally, we present a model, in terms of a Regge-pole expansion, that matches the sum rules and the high-energy observables.Comment: 19 pages, 15 figures and 4 table

The usefulness of c-Kit in the immunohistochemical assessment of melanocytic lesions

C-Kit (CD117), the receptor for the stem cell factor, a growth factor for melanocyte migra- tion and proliferation, has shown differential immunostaining in various benign and malig- nant melanocytic lesions. The purpose of this study is to compare c-Kit immunostaining in benign nevi and in primary and metastatic malignant melanomas, to determine whether c-Kit can aid in the differential diagnosis of these lesions. c-Kit immunostaining was per- formed in 60 cases of pigmented lesions, including 39 benign nevi (5 blue nevi, 5 intra- dermal nevi, 3 junctional nevi, 15 cases of pri- mary compound nevus, 11 cases of Spitz nevus), 18 cases of primary malignant melanoma and 3 cases of metastatic melanoma. The vast majority of nevi and melanomas examined in this study were posi- tive for c-Kit, with minimal differences between benign and malignant lesions. C-Kit cytoplasmatic immunoreactivity in the intraepidermal proliferating nevus cells, was detected in benign pigmented lesions as well as in malignant melanoma, increasing with the age of patients (P=0.007) in both groups. The patient’s age at presentation appeared to be the variable able to cluster benign and malignant pigmented lesions. The percentage of c-Kit positive intraepidermal nevus cells was better associated with age despite other vari- ables (P=0.014). The intensity and percentage of c-Kit positivity in the proliferating nevus cells in the dermis was significantly increased in malignant melanocytic lesions (P=0.015 and P=0.008) compared to benign lesions (compound melanocytic nevi, Spitz nevi, intradermal nevi, blue nevi). Immunostaning for c-Kit in metastatic melanomas was nega- tive. Interestingly in two cases of melanoma occurring on a pre-existent nevus, the melanoma tumor cells showed strong cytoplas- matic and membranous positivity for c-kit, in contrast with the absence of any immunoreac- tivity in pre-existent intradermal nevus cells. C-Kit does not appear to be a strong immuno- histochemical marker for distinguishing melanoma from melanocytic nevi, if we consid- er c-Kit expression in intraepidermal prolifer- ating cells. The c-Kit expression in proliferat- ing melanocytes in the dermis could help in the differential diagnosis between a superfi- cial spreading melanoma (with dermis inva- sion) and a compound nevus or an intradermal nevus. Finally, c-Kit could be a good diagnostic tool for distinguishing benign compound nevi from malignant melanocytic lesions with der- mis invasion and to differentiate metastatic melanoma from primary melanoma