613 research outputs found
Microvascular damage evaluation in systemic sclerosis : the role of nailfold videocapillaroscopy and laser techniques
Microvascular damage and a decrease in peripheral blood perfusion are typical features of systemic sclerosis (SSc) with serious clinical implications, not only for a very early diagnosis, but also for disease progression. Nailfold videocapillaroscopy is a validated and safe imaging technique able to detect peripheral capillary morphology, as well as to classify and to score any nailfold abnormalities into different microangiopathy patterns.
Capillaroscopic analysis is now included in the ACR/EULAR classification criteria for SSc.
The decrease in peripheral blood perfusion is usually associated with microvascular damage in SSc, which may be studied by different methods. Several of these make use of safe laser technologies.
This paper focuses on these new clinical aspects to assess SSc microvascular impairment
INTERACTION BETWEEN NANOFILLED COMPOSITES AND POLYWAVE MULTILED CURING LAMPS: AN IN VITRO STUDY
8nonenoneBattaglia V; Bergantin E; Paolino D; Coero Borga FA; Cadenaro M; Breschi L; Berutti E; Scotti N.Battaglia, V; Bergantin, E; Paolino, D; Coero Borga, Fa; Cadenaro, Milena; Breschi, Lorenzo; Berutti, E; Scotti, Nicol
Development and In Vivo Evaluation of Multidrug Ultradeformable Vesicles for the Treatment of Skin Inflammation
The aim of this work was to evaluate the effect of two chemically different edge activators, i.e., Tween® 80 and sodium deoxycholate, on (i) the physical, mechanical, and biological properties of ultradeformable vesicles, and (ii) the administration of naproxen sodium-loaded multidrug ultradeformable vesicles for the transdermal route in order to obtain therapeutically meaningful drug concentrations in the target tissues and to potentiate its anti-inflammatory effect by association with the antioxidant drug idebenone. The results obtained in this investigation highlighted a synergistic action between naproxen and idebenone in the treatment of inflammatory disease with a more pronounced anti-inflammatory effect in multidrug ultradeformable vesicles compared to the commercial formulation of Naprosyn® gel. Systems made up of Tween® 80 appeared to be the most suitable in terms of percutaneous permeation and anti-inflammatory activity due to the greater deformability of these vesicles compared to multidrug ultradeformable vesicles with sodium deoxycholate. Our findings are very encouraging and suggest the use of these carriers in the topical treatment of inflammatory diseases
Entropy production and fluctuation theorems under feedback control: the molecular refrigerator model revisited
We revisit the model of a Brownian particle in a heat bath submitted to an
actively controlled force proportional to the velocity that leads to thermal
noise reduction (cold damping). We investigate the influence of the continuous
feedback on the fluctuations of the total entropy production and show that the
explicit expression of the detailed fluctuation theorem involves different
dynamics and observables in the forward and backward processes. As an
illustration, we study the analytically solvable case of a harmonic oscillator
and calculate the characteristic function of the entropy production in a
nonequilibrium steady state. We then determine the corresponding large
deviation function which results from an unusual interplay between 'boundary'
and 'bulk' contributions.Comment: 16 pages, 5 figures. References 9,10,13,14,15 added. A few changes in
the text. Accepted for publication in J. Stat. Mec
Working length transfer in the endodontic clinical practice: A comparative study
8The present paper evaluated the accuracy of two different methods for transferring working
length (WL) between manual endodontic instruments and nickel–titanium (NiTi) shaping files.
Thirty root canals of extracted permanent teeth were used. Root canals were divided according to
canal length (CL) and canal curvature (CC). The reference cusp and the root end were flattened to
provide reproducible and accurate measurements. During shaping, the WL measurements were
obtained with manual k-files (KF) and transferred to WaveOne (W1) NiTi reciprocating files using
the traditional method with the endodontic ruler (method I) and an alternative clinical procedure
based on the comparison of the instruments side by side from tip to shank (method II). For each file
and each tested method, two measures were taken by two examiners using Rhino (ver. 4.0, McNeel,
Seattle, WA, USA) software for a total of 360 (30 Ă— 3 Ă— 2 Ă— 2) measures. Analysis of variance was
performed by taking the difference in length (Delta WL, DWL) between files used for the same canal.
The difference between methods I and II for WL transfer was found to be statistically significant
(df = 1; F = 71.52; p < 0.001). The DWL absolute values obtained with method II were found to be
closer to 0 mm (i.e., same length as corresponding KF) than those obtained with method I. Both CL
(df = 2; F = 1.27; p = 0.300) and CC (df = 1; F = 2.22; p = 0.149) did not significantly influence WL
measurements. With respect to WL transfer, method II seemed to better preserve the correct WL
transfer between instruments during the clinical endodontic procedures.openopenMario Alovisi; Mario Dioguardi; Massimo Carossa; Giuseppe Troiano; Maria Chiara Domini; Davide Salvatore Paolino; Giorgio Chiandussi; Elio BeruttiAlovisi, Mario; Dioguardi, Mario; Carossa, Massimo; Troiano, Giuseppe; Chiara Domini, Maria; Paolino, DAVIDE SALVATORE; Chiandussi, Giorgio; Berutti, Eli
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