Apprenticeship migration to three pre-industrial English towns

Tudor and Stuart England was a mobile society. The generally high levels of geographical mobility went hand in hand with various degrees of social and occupational mobility. Some of the most important movements were of people from the countryside to the town, as they were significant as a transfer of resources and an agency of social mobilitYJ their chronological and geographical flows provide an index of both changing urban fortunes and of the levels of spatial integration and economic development upon which these changing fortunes were based. Amongst the types of rural-urban migration, the movement of teenagers to a town to serve an apprenticeship is a particularly valuable topic for study. The training of labour is important in any society and in preindustrial England output could only be raised in many industries through a greater input of labour. The areas from which the apprentices were drawn represent the scale of organisation, economic social and spatial, current in sixteenth and seventeenth century England. This gives an indication of the level of development of the country as it underwent the transition from a society largely based on the discrete daily and weekly contacts around the provincial central places, through an increase in scale to a regional integration based upon county towns, to a~hesive national system. Three county towns were selected, Chester, Gloucester and Shrewsbury, as they each had a good series of apprenticeship records; they represented the foci characteristic of the regional scale of integration and they were associated one with another along the England-Wales border, thus forming a convenient spatial system. The results of the study confirm the findings on mobility in sixteenth and seventeenth century England. Most migrants moved over short distances and a few made long journeys. The propensity to move varied with the status of the apprentices' backgroundsJ generally the higher the status the longer the distance moved. Many apprentices trained in an occupation different to that of their fathers and some of these represented a significant degree of social mobility. Nevertheless, association within the s~me sub-group was common, either based upon the same raw material or upon the type of work undertaken. The three towns organised a regional scale of integration around themselves, reinforcing their roles as important suppliers of goods and services to their hinterlands, the extent of which remained constant throughout the period studied

Fine Structure of Dark Matter Halos and its Effect on Terrestrial Detection Experiments

Terrestrial dark matter detection experiments probe the velocity-space distribution of dark matter particles in the vicinity of the Earth. We present a novel method, to be used in conjunction with standard cosmological simulations of hierarchical clustering, that allows one to extract a truly local velocity-space distribution in exquisite detail. Preliminary results suggest a new picture for this distribution which is decidedly non-Maxwellian but instead is characterized by randomly positioned peaks in velocity space. We discuss the implications of these results for both WIMP and axion detection experiments.Comment: 5 pages, 3 figure

Substructure in the Andromeda Galaxy Globular Cluster System

In the most prominent current scenario of galaxy formation, galaxies form hierarchically through the merger of smaller systems. Such mergers could leave behind dynamical signatures which may linger long after the event. In particular, the globular cluster system (GCS) of a merging satellite galaxy may remain as a distinct sub-population within the GCS of a massive galaxy. Using the latest available globular cluster velocities and metallicities, we present the results of a search for grouping in the GCS of our nearest large spiral galaxy neighbor, M31. A modified friends-of-friends algorithm is used to identify a number of possible merger remnants in projected position, radial velocity and [Fe/H] parameter space. Numerical simulations are used to check that such merger remnants are indeed plausible over the timescales of interest. The identification of stellar streams associated with these groups is required in order to confirm that they represent merger remnants.Comment: 19 pages, 3 figures, accepted for publication in the Ap

Internal jugular vein thrombosis in a warfarinised patient: a case report

<p>Abstract</p> <p>Introduction</p> <p>Internal jugular vein thrombosis (IJVT) is a rare but potentially fatal condition. It usually arises following trauma to the internal jugular vein but is also seen in association with coagulopathies and advanced malignancies as part of a para-neoplastic syndrome.</p> <p>Case presentation</p> <p>We report a case of a 44 year old woman with a strong past medical history and family history of thrombotic disease who presented with abdominal pain and ascites. A stage III ovarian carcinoma was diagnosed and she underwent debulking of the tumour. She sustained a peri-operative haemorrhage and required insertion of a central line into the right internal jugular vein. At one month follow-up she presented as an emergency with a left neck mass and painful swallowing. A duplex ultrasound of her neck identified a left IJVT to the level of the brachiocephalic vein which had occurred despite warfarinisation and an INR of greater than 2. She was commenced on intravenous heparin and the swelling resolved over the course of a week.</p> <p>Conclusion</p> <p>This case illustrates an unusual presentation of a rare condition. In this case, the precise aetiology is unclear as the IJVT may have been related to a coagulopathy or the presence of advanced malignancy and occurred despite adequate anticoagulation.</p

Solar Wakes of Dark Matter Flows

We analyze the effect of the Sun's gravitational field on a flow of cold dark matter (CDM) through the solar system in the limit where the velocity dispersion of the flow vanishes. The exact density and velocity distributions are derived in the case where the Sun is a point mass. The results are extended to the more realistic case where the Sun has a finite size spherically symmetric mass distribution. We find that regions of infinite density, called caustics, appear. One such region is a line caustic on the axis of symmetry, downstream from the Sun, where the flow trajectories cross. Another is a cone-shaped caustic surface near the trajectories of maximum scattering angle. The trajectories forming the conical caustic pass through the Sun's interior and probe the solar mass distribution, raising the possibility that the solar mass distribution may some day be measured by a dark matter detector on Earth. We generalize our results to the case of flows with continuous velocity distributions, such as that predicted by the isothermal model of the Milky Way halo.Comment: 30 pages, 8 figure

The phase-space structure of a dark-matter halo: Implications for dark-matter direct detection experiments

We study the phase-space structure of a dark-matter halo formed in a high resolution simulation of a Lambda CDM cosmology. Our goal is to quantify how much substructure is left over from the inhomogeneous growth of the halo, and how it may affect the signal in experiments aimed at detecting the dark matter particles directly. If we focus on the equivalent of ``Solar vicinity'', we find that the dark-matter is smoothly distributed in space. The probability of detecting particles bound within dense lumps of individual mass less than 10^7 M_\sun h^{-1} is small, less than 10^{-2}. The velocity ellipsoid in the Solar neighbourhood deviates only slightly from a multivariate Gaussian, and can be thought of as a superposition of thousands of kinematically cold streams. The motions of the most energetic particles are, however, strongly clumped and highly anisotropic. We conclude that experiments may safely assume a smooth multivariate Gaussian distribution to represent the kinematics of dark-matter particles in the Solar neighbourhood. Experiments sensitive to the direction of motion of the incident particles could exploit the expected anisotropy to learn about the recent merging history of our Galaxy.Comment: 13 pages, 13 figures, Phys. Rev. D in press. Postscript version with high resolution figures available from http://www.mpa-garching.mpg.de/~ahelmi/research/lcdm_dm.html; some changes in the text; constraints on the effect of bound dark-matter lumps revised; remaining conclusions unchange

Effect of halo modelling on WIMP exclusion limits

WIMP direct detection experiments are just reaching the sensitivity required to detect galactic dark matter in the form of neutralinos. Data from these experiments are usually analysed under the simplifying assumption that the Milky Way halo is an isothermal sphere with maxwellian velocity distribution. Observations and numerical simulations indicate that galaxy halos are in fact triaxial and anisotropic. Furthermore, in the cold dark matter paradigm galactic halos form via the merger of smaller subhalos, and at least some residual substructure survives. We examine the effect of halo modelling on WIMP exclusion limits, taking into account the detector response. Triaxial and anisotropic halo models, with parameters motivated by observations and numerical simulations, lead to significant changes which are different for different experiments, while if the local WIMP distribution is dominated by small scale clumps then the exclusion limits are changed dramatically.Comment: 9 pages, 9 figures, version to appear in Phys. Rev. D, minor change

Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling

Large brain size is one of the defining characteristics of modern humans. Seckel syndrome (MIM 210600), a disorder of markedly reduced brain and body size, is associated with defective ATR-dependent DNA damage signaling. Only a single hypomorphic mutation of ATR has been identified in this genetically heterogeneous condition. We now report that mutations in the gene encoding pericentrin (PCNT)--resulting in the loss of pericentrin from the centrosome, where it has key functions anchoring both structural and regulatory proteins--also cause Seckel syndrome. Furthermore, we find that cells of individuals with Seckel syndrome due to mutations in PCNT (PCNT-Seckel) have defects in ATR-dependent checkpoint signaling, providing the first evidence linking a structural centrosomal protein with DNA damage signaling. These findings also suggest that other known microcephaly genes implicated in either DNA repair responses or centrosomal function may act in common developmental pathways determining human brain and body size