A Study on Proteolytic Enzyme Activity in the Erythrocytes of Diabetic Patients

The present study demonstrates the possibility of increased proteolytic activities in diabetic individuals. Proteolytic activity was measured by the amount of amino group released by the erythrocyte lysate of the diabetic individual using phenylhydrazine treated hemoglobin as substrate. The proteolytic activity in erythrocyte lysates against oxidatively damaged hemoglobin was significantly increased in diabetic individuals compared to controls (p<0.001).The result of this study indicates that in diabetic individuals, proteolytic enzymes degrade many oxidatively altered proteins preventing the accumulation of altered and damaged proteins in the cell

B-meson signatures of a Supersymmetric U(2) flavor model

We discuss B-meson signatures of a Supersymmetric U(2) flavor model, with relatively light (electroweak scale masses) third generation right-handed scalars. We impose current B and K meson experimental constraints on such a theory, and obtain expectations for B->X_s gamma, B->X_s glue, B->X_s l+ l-, B->phi K_s, B_s-B_sbar mixing, and the dilepton asymmetry in B_s. We show that such a theory is compatible with all current data, and furthermore, could reconcile the apparent deviations from Standard Model predictions that have been found in some experiments.Comment: 37 pages, 21 figures, RevTeX4; v.2 - minor modifications to improve readability. Published versio

Serum lactate dehydrogenase level in pre-eclampsia and its correlation with maternal and fetal outcome

Background: Hypertensive disorders are the most common medical disorders during pregnancy. It increases maternal and perinatal morbidity and mortality. The incidence is 7 to 10%. Identifying high risk patients and close monitoring can reduce the complications. Lactate dehydrogenase is a useful biochemical marker and can be used to evaluate maternal complications like Disseminated intravascular coagulation (DIC), HELLP syndrome (Haemolysis, elevated liver enzymes and lowered platelets), pulmonary edema, renal failure and fetal complications like Fetal growth restriction (FGR) APGAR score ≤7 at 5 min and Neonatal intensive care unit (NICU) admissions. The objective of this study was to estimate serum Lactate dehydrogenase levels (LDH) in pre-eclampsia patients and study the correlation between increased LDH levels and maternal and fetal outcome.Methods: It was a prospective study from October 2015 to May 2017 at M. S. Ramaiah medical college and hospitals, Bangalore.Results: The incidence of maternal and foetal complications was increased with higher serum LDH levels. With serum LDH >than 600 IU/l the incidence of HELLP syndrome, DIC, pulmonary edema was statistically significant. It also correlated with increased creatinine levels and decreased platelets with p value<0.001. The foetal complications including FGR NICU admission and Apgar score <7 at 5 min was statistically significant. The liver enzymes and serum creatinine correlated with increased LDH levels.Conclusions: Maternal and foetal complications are increased with raised LDH levels, and it can be used as a biochemical marker to achieve a better outcome

Circulating antigen tests and urine reagent strips for diagnosis of active schistosomiasis in endemic areas

Background: Point-of-care (POC) tests for diagnosing schistosomiasis include tests based on circulating antigen detection and urine reagent strip tests. If they had sufficient diagnostic accuracy they could replace conventional microscopy as they provide a quicker answer and are easier to use. Objectives: To summarise the diagnostic accuracy of: a) urine reagent strip tests in detecting activeSchistosoma haematobium infection, with microscopy as the reference standard; and b) circulating antigen tests for detecting active Schistosoma infection in geographical regions endemic for Schistosoma mansoni or S. haematobium or both, with microscopy as the reference standard. Search methods: We searched the electronic databases MEDLINE, EMBASE, BIOSIS, MEDION, and Health Technology Assessment (HTA) without language restriction up to 30 June 2014. Selection criteria We included studies that used microscopy as the reference standard: for S. haematobium, microscopy of urine prepared by filtration, centrifugation, or sedimentation methods; and for S. mansoni, microscopy of stool by Kato-Katz thick smear. We included studies on participants residing in endemic areas only. Data collection and analysis: Two review authors independently extracted data, assessed quality of the data using QUADAS-2, and performed meta-analysis where appropriate. Using the variability of test thresholds, we used the hierarchical summary receiver operating characteristic (HSROC) model for all eligible tests (except the circulating cathodic antigen (CCA) POC for S. mansoni, where the bivariate random-effects model was more appropriate). We investigated heterogeneity, and carried out indirect comparisons where data were sufficient. Results for sensitivity and specificity are presented as percentages with 95% confidence intervals (CI). Main results; We included 90 studies; 88 from field settings in Africa. The median S. haematobiuminfection prevalence was 41% (range 1% to 89%) and 36% for S. mansoni (range 8% to 95%). Study design and conduct were poorly reported against current standards. Tests for S. haematobium Urine reagent test strips versus microscopy Compared to microscopy, the detection of microhaematuria on test strips had the highest sensitivity and specificity (sensitivity 75%, 95% CI 71% to 79%; specificity 87%, 95% CI 84% to 90%; 74 studies, 102,447 participants). For proteinuria, sensitivity was 61% and specificity was 82% (82,113 participants); and for leukocyturia, sensitivity was 58% and specificity 61% (1532 participants). However, the difference in overall test accuracy between the urine reagent strips for microhaematuria and proteinuria was not found to be different when we compared separate populations (P = 0.25), or when direct comparisons within the same individuals were performed (paired studies; P = 0.21). When tests were evaluated against the higher quality reference standard (when multiple samples were analysed), sensitivity was marginally lower for microhaematuria (71% vs 75%) and for proteinuria (49% vs 61%). The specificity of these tests was comparable. Antigen assay Compared to microscopy, the CCA test showed considerable heterogeneity; meta-analytic sensitivity estimate was 39%, 95% CI 6% to 73%; specificity 78%, 95% CI 55% to 100% (four studies, 901 participants). Tests for S. mansoni Compared to microscopy, the CCA test meta-analytic estimates for detecting S. mansoni at a single threshold of trace positive were: sensitivity 89% (95% CI 86% to 92%); and specificity 55% (95% CI 46% to 65%; 15 studies, 6091 participants) Against a higher quality reference standard, the sensitivity results were comparable (89% vs 88%) but specificity was higher (66% vs 55%). For the CAA test, sensitivity ranged from 47% to 94%, and specificity from 8% to 100% (four studies, 1583 participants). Authors' conclusions: Among the evaluated tests for S. haematobium infection, microhaematuria correctly detected the largest proportions of infections and non-infections identified by microscopy. The CCA POC test for S. mansoni detects a very large proportion of infections identified by microscopy, but it misclassifies a large proportion of microscopy negatives as positives in endemic areas with a moderate to high prevalence of infection, possibly because the test is potentially more sensitive than microscopy

Performance of Nickel-Cadmium Batteries on the GOES-1 Series of Weather Satellites

This is an errata from an original paper published in the 1997 NASA Aerospace Battery workshop proceedings. A minor change was made to the second equation on page 98 and table 4 was revised during the final preparation of the paper. These changes were inadvertently left out of the final proceedings. These pages are reproduced in their entirety

Performance of Nickel-Cadmium Batteries on the GOES I-K Series of Weather Satellites

The US National Oceanic and Atmospheric Administration (NOAA) operates the Geostationary Operational Environmental Satellite (GOES) spacecraft (among others) to support weather forecasting, severe storm tracking, and meteorological research by the National Weather Service (NWS). The latest in the GOES series consists of 5 spacecraft (originally named GOES I-M), three of which are in orbit and two more in development. Each of five spacecraft carry two Nickel-Cadmium batteries, with batteries designed and manufactured by Space Systems Loral (SS/L) and cells manufactured by Gates Aerospace Batteries (sold to SAFT in 1993). The battery, which consists of 28 cells with a 12 Ah capacity, provides the spacecraft power needs during the ascent phase and during the semi-annual eclipse seasons lasting for approximately 45 days each. The maximum duration eclipses are 72 minutes long which result in a 60 percent depth of discharge (DOD) of the batteries. This paper provides a description of the batteries, reconditioning setup, DOD profile during a typical eclipse season, and flight performance from the 3 launched spacecraft (now GOES 8, 9, and 10) in orbit

Design and Flight Performance of NOAA-K Spacecraft Batteries

The US National Oceanic and Atmospheric Administration (NOAA) operates the Polar Operational Environmental Satellite (POES) spacecraft (among others) to support weather forecasting, severe storm tracking, and meteorological research by the National Weather Service (NWS). The latest in the POES series of spacecraft, named as NOAA-KLMNN', one is in orbit and four more are in various phases of development. The NOAA-K spacecraft was launched on May 13, 1998. Each of these spacecraft carry three Nickel-Cadmium batteries designed and manufactured by Lockheed Martin. The battery, which consists of seventeen 40 Ah cells manufactured by SAFT, provides the spacecraft power during the ascent phase, orbital eclipse and when the power demand is in excess of the solar array capability. The NOAA-K satellite is in a 98 degree inclination, 7:30AM ascending node orbit. In this orbit the satellite experiences earth occultation only 25% of the year. This paper provides a brief overview of the power subsystem, followed by the battery design and qualification, the cell life cycle test data, and the performance during launch and in orbit

Collider Signature of Bulk Neutrinos in Large Extra Dimensions

We consider the collider signature of right-handed neutrinos propagating in $\delta$ (large) extra dimensions, and interacting with Standard Model fields only through a Yukawa coupling to the left-handed neutrino and the Higgs boson. These theories are attractive as they can explain the smallness of the neutrino mass, as has already been shown. We show that if $\delta$ is bigger than two, it can result in an enhancement in the production rate of the Higgs boson, decaying either invisibly or to a $b$ anti-$b$ quark pair, associated with an isolated high $p_T$ charged lepton and missing transverse energy at future hadron colliders, such as the LHC. The enhancement is due to the large number of Kaluza-Klein neutrinos produced in the final state. The observation of the signal event would provide an opportunity to distinguish between the normal and inverted neutrino mass hierarchies, and to determine the absolute scale of neutrino masses by measuring the asymmetry of the observed event numbers in the electron and muon channels.Comment: 31 pages, 13 figures. v2: Added discussion on PDF uncertainties, added reference

Boosting and lassoing new prostate cancer SNP risk factors and their connection to selenium

We begin by arguing that the often used algorithm for the discovery and use of disease risk factors, stepwise logistic regression, is unstable. We then argue that there are other algorithms available that are much more stable and reliable (e.g. the lasso and gradient boosting). We then propose a protocol for the discovery and use of risk factors using lasso or boosting variable selection. We then illustrate the use of the protocol with a set of prostate cancer data and show that it recovers known risk factors. Finally, we use the protocol to identify new and important SNP based risk factors for prostate cancer and further seek evidence for or against the hypothesis of an anticancer function for Selenium in prostate cancer. We find that the anticancer effect may depend on the SNP-SNP interaction and, in particular, which alleles are present