1,762 research outputs found
Searching for additional heating - [OII] emission in the diffuse ionized gas of NGC891, NGC4631 and NGC3079
We present spectroscopic data of ionized gas in the disk--halo regions of
three edge-on galaxies, NGC 891, NGC 4631 and NGC 3079, covering a wavelength
range from [\ion{O}{2}] 3727\AA to [\ion{S}{2}] 6716.4\AA.
The inclusion of the [\ion{O}{2}] emission provides new constraints on the
properties of the diffuse ionized gas (DIG), in particular, the origin of the
observed spatial variations in the line intensity ratios. We used three
different methods to derive electron temperatures, abundances and ionization
fractions along the slit. The increase in the [\ion{O}{2}]/H line ratio
towards the halo in all three galaxies requires an increase either in electron
temperature or in oxygen abundance. Keeping the oxygen abundance constant
yields the most reasonable results for temperature, abundances, and ionization
fractions. Since a constant oxygen abundance seems to require an increase in
temperature towards the halo, we conclude that gradients in the electron
temperature play a significant role in the observed variations in the optical
line ratios from extraplanar DIG in these three spiral galaxies.Comment: 43 pages, 29 figure
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Chronic nicotine administration restores brain region specific upregulation of oxytocin receptor binding levels in a G72 mouse model of schizophrenia.
Nicotine dependence and schizophrenia are two mental health disorders with remarkably high comorbidity. Cigarette smoking is particularly prevalent among schizophrenic patients and it is hypothesized to comprise a form of self-medication for relieving cognitive deficits in these patients. Emerging evidence suggests a role of the neurohypophysial peptide oxytocin in the modulation of drug addiction, as well as schizophrenia symptomology; however, the underlying mechanism remains unclear. Therefore, we sought to investigate the effects of chronic nicotine administration on oxytocin receptor (OTR) binding in the brain of a transgenic mouse model of schizophrenia that carries a bacterial artificial chromosome of the human G72/G30 locus (G72Tg). Female wild-type (WT) and heterozygous G72 transgenic CD-1 mice were treated with a chronic nicotine regimen (24 mg/kg/day, osmotic minipumps for 14 days) and quantitative autoradiographic mapping of oxytocin receptors was carried out in brains of these animals. OTR binding levels were higher in the cingulate cortex (CgCx), nucleus accumbens (Acb) and central amygdala (CeA) of saline treated G72Tg mice compared with WT control mice. Chronic nicotine administration reversed this upregulation in the CgCx and CeA. Interestingly, chronic nicotine administration induced an increase in OTR binding in the CeA of solely WT mice. These results indicate that nicotine administration normalizes the dysregulated central oxytocinergic system of this mouse model of schizophrenia and may contribute towards nicotine's ability to modulate cognitive deficits which are common symptoms of schizophrenia. This article is protected by copyright. All rights reserved
Diffuse Ionized Gas in the Dwarf Irregular Galaxy DDO 53
The spectral characteristics throughout the dwarf irregular galaxy DDO 53 are
studied. The results are very similar to those for other irregular galaxies:
high excitation and low values of the [SII]/Halpha ratio. The most likely
ionization source is photon leakage from the classical HII regions, without any
other source, although the interstellar medium of the galaxy is quite
perturbed. Moreover, the physical conditions throughout the galaxy do not
change very much because both the photon leakage percentage and the ionization
temperature are very similar. In addition, the determined metal content for two
HII regions indicates that DDO 53 is a low-metallicity galaxy.Comment: 32 pages, 9 figures, 7 tables. AJ, in pres
A Scintillating Fiber Tracker With SiPM Readout
We present a prototype for the first tracking detector consisting of 250
micron thin scintillating fibers and silicon photomultiplier (SiPM) arrays. The
detector has a modular design, each module consists of a mechanical support
structure of 10mm Rohacell foam between two 100 micron thin carbon fiber skins.
Five layers of scintillating fibers are glued to both top and bottom of the
support structure. SiPM arrays with a channel pitch of 250 micron are placed in
front of the fibers. We show the results of the first module prototype using
multiclad fibers of types Bicron BCF-20 and Kuraray SCSF-81M that were read out
by novel 32-channel SiPM arrays from FBK-irst/INFN Perugia as well as
32-channel SiPM arrays produced by Hamamatsu. A spatial resolution of 88 micron
+/- 6 micron at an average yield of 10 detected photons per minimal ionizig
particle has been achieved.Comment: 5 pages, 7 figures, submitted as proceedings to the 11th Topical
Seminar on Innovative Particle and Radiation Detectors (IPRD08
Synaptic and cellular changes induced by the schizophrenia susceptibility gene G72 are rescued by N-acetylcysteine treatment
Genetic studies have linked the primate-specific gene locus G72 to the development of schizophrenia and bipolar disorder. Transgenic mice carrying the entire gene locus express G72 mRNA in dentate gyrus (DG) and entorhinal cortex, causing altered electrophysiological properties of their connections. These transgenic mice exhibit behavioral alterations related to psychiatric diseases, including cognitive deficits that can be reversed by treatment with N-acetylcysteine, which was also found to be effective in human patients. Here, we show that G72 transgenic mice have larger excitatory synapses with an increased amount of N-methyl-d-aspartate (NMDA) receptors in the molecular layer of DG, compared with wild-type littermates. Furthermore, transgenic animals have lower number of dentate granule cells with a parallel, but an even stronger decrease in the number of excitatory synapses in the molecular layer. Importantly, we also show that treatment with N-acetylcysteine can effectively normalize all these changes in transgenic animals, resulting in a state similar to wild-type mice. Our results show that G72 transcripts induce robust alterations in the glutamatergic system at the synaptic level that can be rescued with N-acetylcysteine treatment
ReconViguRation: Reconfiguring Physical Keyboards in Virtual Reality.
Physical keyboards are common peripherals for personal computers and are efficient standard text entry devices. Recent research has investigated how physical keyboards can be used in immersive head-mounted display-based Virtual Reality (VR). So far, the physical layout of keyboards has typically been transplanted into VR for replicating typing experiences in a standard desktop environment. In this paper, we explore how to fully leverage the immersiveness of VR to change the input and output characteristics of physical keyboard interaction within a VR environment. This allows individual physical keys to be reconfigured to the same or different actions and visual output to be distributed in various ways across the VR representation of the keyboard. We explore a set of input and output mappings for reconfiguring the virtual presentation of physical keyboards and probe the resulting design space by specifically designing, implementing and evaluating nine VR-relevant applications: emojis, languages and special characters, application shortcuts, virtual text processing macros, a window manager, a photo browser, a whack-a-mole game, secure password entry and a virtual touch bar. We investigate the feasibility of the applications in a user study with 20 participants and find that, among other things, they are usable in VR. We discuss the limitations and possibilities of remapping the input and output characteristics of physical keyboards in VR based on empirical findings and analysis and suggest future research directions in this area
The Social context of motorcycle riding and the key determinants influencing rider behavior: A qualitative investigation
Objective: Given the increasing popularity of motorcycle riding and heightened risk of injury or death associated with being a rider, this study explored rider behaviour as a determinant of rider safety and, in particular, key beliefs and motivations which influence such behaviour. To enhance the effectiveness of future education and training interventions, it is important to understand ridersâ own views about what influences how they ride. Specifically, this study sought to identify key determinants of ridersâ behaviour in relation to the social context of riding including social and identity-related influences relating to the group (group norms and group identity) as well as the self (moral/personal norm and self-identity). ----- ----- Method: Qualitative research was undertaken via group discussions with motorcycle riders (n = 41). Results: The findings revealed that those in the group with which one rides represent an important source of social influence. Also, the motorcyclist (group) identity was associated with a range of beliefs, expectations, and behaviours considered to be normative. Exploration of the construct of personal norm revealed that riders were most cognizant of the âwrong things to doâ when riding; among those issues raised was the importance of protective clothing (albeit for the protection of others and, in particular, pillion passengers). Finally, self-identity as a motorcyclist appeared to be important to a riderâs self-concept and was likely to influence their on-road behaviour. ----- ----- Conclusion: Overall, the insight provided by the current study may facilitate the development of interventions including rider training as well as public education and mass media messages. The findings suggest that these interventions should incorporate factors associated with the social nature of riding in order to best align it with some of the key beliefs and motivations underpinning ridersâ on-road behaviours
Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis
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