COVID-19 Pandemic and Internet Traffic in Poland: Evidence from Selected Regional Networks, Journal of Telecommunications and Information Technology, 2021, nr 3

The COVID-19 pandemic has forced governments all over the world to impose lockdowns keeping citizens at home in order to limit the virus spread rate. The paper compares weekly traffic samples captured in the selected nodes of the network managed by NASK – National Research Institute during the pre-lockdown period, i.e. between January 27 and February 3, 2020, with those captured between March 30 and April 6, 2020, i.e. after the lockdown was announced. The presented results show changes in network traffic observed during the periods of time in question and illustrate the evolution in the popularity of top network service

On the Design of the TCP/AQM Traffic Flow Control Mechanisms, Journal of Telecommunications and Information Technology, 2012, nr 4

Several aspects of the TCP/AQM system design are discussed that may affect performance of the network. Namely, due to decentralized structure of the network traffic flow control system in which traffic rate control tasks are delegated to autonomous agents, it may be possible for the agents to profitably re-engineer the TCP congestion control algorithm at the cost of the overall performance of the network. In this paper it is shown how the commonly applied TCP/AQM design procedures may give rise to mechanisms that are prone to attacks discreetly moving the network traffic flow away from the desired operating point. Furthermore, a short discussion is presented concerning the countermeasures that can be taken to reduce these effects

Single-shot carrier-envelope-phase measurement in ambient air

The ability to measure and control the carrier envelope phase (CEP) of few-cycle laser pulses is of paramount importance for both frequency metrology and attosecond science. Here, we present a phase meter relying on the CEP-dependent photocurrents induced by circularly polarized few-cycle pulses focused between electrodes in ambient air. The new device facilitates compact single-shot, CEP measurements under ambient conditions and promises CEP tagging at repetition rates orders of magnitude higher than most conventional CEP detection schemes as well as straightforward implementation at longer wavelengths

Weight status, BMI and physical fitness in polish youth: relationships between 1986 and 2016

One of the components affecting the level of health is physical fitness and diets, which is also considered the foundation of a healthy lifestyle. Methods: Samples by survey ranged from 871 to 1,417 (boys) and from 843 to 1,326 (girls). Speed (5 m run), agility (figure-8-run), explosive power (vertical jump), flexibility (stand and reach) and cardiovascular fitness (step test) were measured. The Body Mass Index (BMI) of each student was classified as Thin, Normal weight or Overweight/Obese (Owt/Ob) relative to International Obesity Task Force (IOTF) criteria. Fitness items were compared among weight status groups and across surveys with sex-specific analyses of covariance. Regressions of each fitness item on the BMI in the four surveys were done using linear and nonlinear quadratic models. Results: Performances on all fitness tests except flexibility were poorer among Owt/Ob compared to Normal and Thin youth, but performances on fitness tests within weight status groups did not differ consistently across surveys. Conclusions: Relationships between the BMI and fitness tests varied across surveys, but suggested reasonably consistent curvilinear relationships between fitness tests and the BMI among boys more so than girls.info:eu-repo/semantics/publishedVersio

Perception of Nuclear Energy and Coal in France and the Netherlands

This study focuses on the perception of large scale application of nuclear energy and coal in the Netherlands and France. The application of these energy-sources and the risks and benefits are judged differently by various group in society. In Europe, France has the highest density of nuclear power plants and the Netherlands has one of the lowest. In both countries scientists and social scientists completed a questionnaire assessing the perception of the large scale application of both energy sources. Furthermore, a number of variables relating to the socio cultural and political circumstances were measured. The results indicate that the French had a higher risk perception and a more negative attitude toward nuclear power than the Dutch. But they also assess the benefits of the use of nuclear power to be higher. Explanations for these differences are discussed

Human-animal chimeras for vaccine development: an endangered species or opportunity for the developing world?

<p>Abstract</p> <p>Background</p> <p>In recent years, the field of vaccines for diseases such as Human Immunodeficiency Virus (HIV) which take a heavy toll in developing countries has faced major failures. This has led to a call for more basic science research, and development as well as evaluation of new vaccine candidates. Human-animal chimeras, developed with a 'humanized' immune system could be useful to study infectious diseases, including many neglected diseases. These would also serve as an important tool for the efficient testing of new vaccine candidates to streamline promising candidates for further trials in humans. However, developing human-animal chimeras has proved to be controversial.</p> <p>Discussion</p> <p>Development of human-animal chimeras for vaccine development has been slowed down because of opposition by some philosophers, ethicists and policy makers in the west-they question the moral status of such animals, and also express discomfort about transgression of species barriers. Such opposition often uses a contemporary western world view as a reference point. Human-animal chimeras are often being created for diseases which cause significantly higher morbidity and mortality in the developing world as compared to the developed world. We argue in our commentary that given this high disease burden, we should look at socio-cultural perspectives on human-animal chimera like beings in the developing world. On examination, it's clear that such beings have been part of mythology and cultural descriptions in many countries in the developing world.</p> <p>Summary</p> <p>To ensure that important research on diseases afflicting millions like malaria, HIV, Hepatitis-C and dengue continues to progress, we recommend supporting human-animal chimera research for vaccine development in developing countries (especially China and India which have growing technical expertise in the area). The negative perceptions in some parts of the west about human-animal chimeras can be used as an opportunity for nurturing important vaccine development research in the developing world.</p

Asymmetric Strand Segregation: Epigenetic Costs of Genetic Fidelity?

Asymmetric strand segregation has been proposed as a mechanism to minimize effective mutation rates in epithelial tissues. Under asymmetric strand segregation, the double-stranded molecule that contains the oldest DNA strand is preferentially targeted to the somatic stem cell after each round of DNA replication. This oldest DNA strand is expected to have fewer errors than younger strands because some of the errors that arise on daughter strands during their synthesis fail to be repaired. Empirical findings suggest the possibility of asymmetric strand segregation in a subset of mammalian cell lineages, indicating that it may indeed function to increase genetic fidelity. However, the implications of asymmetric strand segregation for the fidelity of epigenetic information remain unexplored. Here, I explore the impact of strand-segregation dynamics on epigenetic fidelity using a mathematical-modelling approach that draws on the known molecular mechanisms of DNA methylation and existing rate estimates from empirical methylation data. I find that, for a wide range of starting methylation densities, asymmetric—but not symmetric—strand segregation leads to systematic increases in methylation levels if parent strands are subject to de novo methylation events. I found that epigenetic fidelity can be compromised when enhanced genetic fidelity is achieved through asymmetric strand segregation. Strand segregation dynamics could thus explain the increased DNA methylation densities that are observed in structured cellular populations during aging and in disease

Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation

The idea that stem cells of adult tissues with high turnover are protected from DNA replication-induced mutations by maintaining the same 'immortal' template DNA strands together through successive divisions has been tested in several tissues. In the epithelium of the small intestine, the provided evidence was based on the assumption that stem cells are located above Paneth cells. The results of genetic lineage-tracing experiments point instead to crypt base columnar cells intercalated between Paneth cells as bona fide stem cells. Here we show that these cells segregate most, if not all, of their chromosomes randomly, both in the intact and in the regenerating epithelium. Therefore, the 'immortal' template DNA strand hypothesis does not apply to intestinal epithelial stem cells, which must rely on other strategies to avoid accumulating mutations