telederm.org: Freely Available Online Consultations in Dermatology

Studies have shown that skin disorders can be reliably diagnosed by online consultations. These consultations are provided free of charge by a new nonprofit organization of skin doctors worldwid

Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation

Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totalling 279 lesions. We have identified a set of eight markers that distinguish naevi from melanoma. None of markers or parameters assessed differentiated benign from dysplastic naevi. Indeed, the naevi clustered tightly in terms of their immunostaining patterns whereas primary melanomas showed more diverse staining patterns. A small subset of histopathologically benign lesions had elevated levels of multiple markers associated with melanoma, suggesting that these represent naevi with an increased potential for transformation to melanoma

Dermoscopic evaluation of nodular melanoma

Importance: Nodular melanoma (NM) is a rapidly progressing potentially lethal skin tumor for which early diagnosis is critical

Nonmelanoma Skin Cancer of the Head and Neck Clinical Evaluation and Histopathology

WOS: 000311860700004PubMed ID: 23084295Clinical and histopathologic features of nonmelanoma skin cancer, physical examination, and diagnostic methods (biopsy, dermoscopy, confocal microscopy) are summarized. A diagnostic algorithm provides a useful summarization of differential diagnosis of basal cell carcinoma, actinic keratosis, Bowen's disease, and squamous cell carcinoma

A pigmented, hemorrhagic genital wart: Clinical, dermoscopic, and histopathologic features

65th Annual Meeting of the American-Academy-of-Dermatology -- FEB 02-06, 2007 -- Washington, DCWOS: 000243972800389Amer Acad Dermato

Trichilemmal cyst with homogeneous blue pigmentation on dermoscopy

WOS: 000271495600015PubMed ID: 19916979A 61-year-old woman was referred to our dermoscopy unit for a pigmented lesion that had been present on her left arm for 8 years. The patient did not notice any enlargement or change in colour. On dermoscopy, homogeneous blue pigmentation was seen. The lesion was excised with the pre-operative diagnosis of melanoma, blue naevus and dermatofibroma. Histopathological examination showed a trichilemmal cyst in the mid-dermis. Although homogeneous blue pigmentation on dermoscopy is the hallmark of blue naevus, it may be seen in metastatic melanoma and exceptionally in hemosiderotic and cellular types of dermatofibroma. Trichilemmal cyst should be borne in mind also in the dermoscopic differential diagnosis

Different dermoscopic faces of dermatofibromas

WOS: 000248992700003PubMed ID: 17560684Background: Central white scarlike patch and a delicate pigment network at the periphery is the typical appearance of dermatofibromas on dermoscopy. Objective: We aimed to analyze the different dermoscopic appearances of dermatofibromas. Methods: Fifty-two dermatofibromas with dermoscopic features different from the classic type, which were detected between May 2003 and July 2005, were evaluated. Results: Globules in the scarlike area (38.5%), linear/irregular crypts (26.9%), lentigo-like reticular pigmentation (23%), homogeneous blue-gray pigmentation (5.9%), and erythematous homogeneous area surrounding the white patch (3.8%) were the patterns observed. In addition, dermoscopic features of an atrophic variant of dermatofibroma are described, which was seen in one lesion (1.9%). Limitations: None. Conclusion: Dermatofibromas have various dermoscopic features. Among them, "linear, irregular crypts" is not unusual and is described in this study. Homogeneous bluish pigmentation on dermoscopy may be a possible clue for the diagnosis of hemosiderotic variants of dermatofibromas