111 research outputs found
Liquid-liquid extraction of transition metal cations by glyoximes and their macrocyclic glyoxime ether derivatives
Liquid-liquid extraction of various alkalis (Li+, Na +, K+, and Cs+), transition metals (Co 2+, Ni2+, Cu2+, Zn2+, Cd 2+, and Hg2+), and Pb2+ cations with phenylglyoxime (L1), p-tolylglyoxime (L2), N′-(4′-Benzo[15-crown-5]) phenylaminoglyoxime (L3), and N′-(4′-Benzo[15-crown-5])-p- tolylaminoglyoxime (L4) from the aqueous phase into the organic phase was carried out. For comparison, the corresponding two glyoximes and their macrocyclic glyoxime ether derivatives were also examined. Crown ether groups having ligands (L3, L4) carry especially Na+ cation from aqueous phase to organic phase. The extraction equilibrium constants (K ex) for complexes of ligands with Cu2+ and Hg2+ metal picrates between dichloromethane and water have been determined at 25°C. The values of the extraction constants (log K ex) were determined to be 12.27, 13.37, 12.94, and 12.39 for Cu2+ and 10.29, 10.62, 11.53, and 11.97 for Hg2+ with L1-L4, respectively. © 2013 Nazan Karapinar et al
Analytical Methods for Viable and Rapid Determination of Organochlorine Pesticides in Water and Soil Samples
Acute Toxicity of Organophosphorus Pesticides and Their Degredation By-Products to Daphnia Magna, Lepidium Sativum and Vibrio Fischeri
Improving implant training for physicians and their teams in under-represented regions
The burden of cardiovascular disease is increasing globally, with low- and middle-income countries (LMICs) absorbing most of the burden while lacking the necessary healthcare infrastructure to combat the increase. In particular, the disparity in pacemaker implants between high-income countries and LMICs is glaring, partially spurned by reduced numbers of physicians and supporting staff who are trained in pacemaker implant technique. Herein, we will discuss current pacemaker implant training models, outline training frameworks that can be applied to underserved regions, and review adjunctive training techniques that can help supplement traditional training models in LMICs
The Validity and Reliability of the Turkish Version of the Integrative Self-knowledge Scale
AbstractThe aim of this research is to examine the validity and reliability of the Turkish version of the Integrative self -knowledge Scale (ISKS; Ghorbani, Watson, & Hargis, 2008). Participants were 396 university students (277 were female and 119 were male) from Sakarya University. The results of confirmatory factor analysis indicated that the three dimensional model was well fitted and Chi-Square value (x2=108. 38, df=49, p=0. 00) which was calculated for the adaptation of the model was found to be significant. The goodness of fit index values of the model were RMSEA=.055, NFI=.97, CFI=.98, IFI=.98, RFI=.96, GFI=.96, and SRMR=.041. The internal consistency coefficients of three subscales were .74, .77, and .83, respectively. The overall internal consistency coefficient of the scale was .86. The corrected item-total correlations of ISKS ranged from .37 to .67. Overall findings demonstrated that this scale had high validity and reliability scores and that it may be used as a valid and reliable instrument in order to assess self-knowledge levels of individuals
Genetic polymorphism in the serotonin transporter gene-linked polymorphic region and response to serotonin reuptake inhibitors in patients with premature ejaculation
OBJECTIVES: Serotonin plays a central role in ejaculation and selective serotonin reuptake inhibitors have been successfully used to treat premature ejaculation. Here, we evaluated the relationship between a polymorphism in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the response of patients with premature ejaculation to SSRI medication. METHODS: Sixty-nine premature ejaculation patients were treated with 20 mg/d paroxetine for three months. The Intravaginal Ejaculatory Latency Time and International Index of Erectile Function scores were compared with baseline values. The patients were scored as having responded to therapy when a 2-fold or greater increase was observed in Intravaginal Ejaculatory Latency Time compared with baseline values after three months. Three genotypes of 5-HTTLPR were studied: LL, LS and SS. The appropriateness of the allele frequencies in 5-HTTLPR were analyzed according to Hardy-Weinberg equilibrium using the χ2-test. RESULTS: The short (S) allele of 5-HTTLPR was significantly more frequent in responders than in nonresponders (
Casein fibres for wound healing
The name casein is given to a family of phosphoproteins which is commonly found in milk. Until recently, this was a constituent of milk that was commonly discarded; however today, it is widely used in health supplements all over the world. In this work, a high loading (50 wt%) of casein is mixed with a solution of polycaprolactone (PCL) to produce bandage-like fibres with an average fibre diameter of 1.4 ± 0.5 µm, which would be used to cover wounds in a series of tests with diabetic rats. Mouse fibroblast cell viability tests show that the casein-loaded fibres had little cytotoxicity with over 90% observed viability. A 14-day in vivo trial involving three groups of rats, used as control (no treatment), pure PCL fibres and casein-loaded fibres, showed that the casein within the fibres contributed to a significantly more extensive healing process. Histological analysis showed increased development of granulation tissue and follicle regrowth for the casein-loaded fibres. Further analysis showed that casein-loaded fibres have significantly lower levels of TNF-α, TGF-β IL-1β, NF-κB and IL-6, contributing to superior healing. The results presented here show an economical and simple approach to advanced wound healing
Levels of Organochlorine Pesticides and Heavy Metals in Surface Waters of Konya Closed Basin, Turkey
The concentrations of organochlorine pesticides (OCPs), including α-, β-, γ-, and δ-hexachlorocyclohexane (HCH), heptachlor, heptachlor epoxide, dieldrin, aldrin, endrin, endrin aldehyde, endrin ketone, endosulfan I, endosulfan II, endosulfan sulfate, p,p′-DDE, p,p′-DDD, p,p′-DDT, methoxychlor, chlordane I, chlordane II, and heavy metals, such as As, Cr, Cu, Fe, Mn, and Ni in surface water samples from the Konya closed basin were determined to evaluate the level of contamination. Among all HCH isomers, β-HCH is the main isomer with a concentration range of 0.015–0.065 μg/L. DDE, DDD, and DDT were almost determined in all samples, in which DDE isomer had the highest concentration ranged from not detected to 0.037 μg/L. In all studied OCPs, aldrin showed the highest concentration at 0.220 μg/L. The concentrations of heavy metals in water samples were observed with order: Mn < Cu < Ni < As < Cr < Fe. In some samples, As, Fe, and Cr concentrations exceeded the drinking water quality recommended by EU, US EPA, WHO, and Turkish Regulation, while Cu, Ni, and Mn concentrations are below the guideline values. The levels of both OCPs and heavy metals were also compared with other previously published data
Evaluation of the impact of warfarin time in therapeutic range on outcomes of patients with atrial fibrillation in Turkey: Perspectives from the observational, prospective WATER Registry
Background: Warfarin is highly efficacious in reducing stroke risk in patients with atrial fibrillation (AF). However, its safety and efficacy in stroke prevention is markedly influenced by its time in therapeutic range (TTR). The quality of anticoagulant therapy varies considerably among countries. Representative data concerning the quality of anticoagulant therapy and its effects on clinical outcomes in Turkey are lacking.
Methods: Warfarin in Therapeutic Range (WATER) registry is a prospective, observational study which followed 572 AF patients (mean age 67.3 ± 12 years; females 60%; 71% non-valvular AF) treated with warfarin.
Results: At a median of 22-month follow-up, the mean TTR value was 42.3 ± 18% (median: 40%) for the whole population and lower in non-valvular AF su group than valvular AF subgroup (40.3 ± 18 vs. 46.9 ± 19, respectively, p < 0.001). Death, cardiac hospitalÂization and minor bleeding rates were higher in the group with TTR value < 40% than the group with > 40% (3.4% vs. 5.9%; 28.6% vs. 35.4%; 36.5% vs. 41.7%, respectively, all of them p < 0.001). A correlation analysis showed a negative correlation between age and TTR value (r = –0.178, p < 0.001). Mean CHA2DS2VASc score was 3.63 ± 1.5 and mean HASBLED score was 2.38 ± 1.01 in the non-valvular AF group. A negative correlation was observed between TTR levels and CHA2DS2VASc score.
Conclusions: WATER provides insight into the anticoagulation control status of AF patients in Turkey. The quality of anticoagulation was poor. Strategies should be undertaken by clinicians and patients to improve TTR. New oral anticoagulant agents may be perfect alternatives for non-valvular AF patients
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