2,350 research outputs found
Galileo Probe Mass Spectrometer
During the past year, the Principal Investigator's research carried out under this contract has focused on an analysis of the implications of Galileo Probe Mass Spectrometer (GPMS) results for the origin of Jupiter's atmosphere and the origin of the ice and other possible volatiles on the Galilean satellites
Outer Solar System Nomenclature
The Principal Investigator's responsibilities on this grant fell into two categories according to his participation. In the nomenclature work of the International Astronomical Union (IAU). Owen is chair of the Task Group for the Outer Solar System. He is also a member of the IAU's Working Group on Planetary and Satellite Nomenclature (WGPSN) which is composed of the chairs of the several Task Groups plus the presidents of two IAU Commissions and several outside consultants. The WGPSN is presided over by its President, Professor Kaare Aksnes from the Rosseland Institute for Theoretical Astrophysics in Oslo, Norway
Six decades of glacier mass changes around Mt. Everest are revealed by historical and contemporary images
The accurate quantification of current and past Himalayan glacier mass budgets is vital if we are to understand the evolution of the Asian water tower, which provides water to the planetâs most populous region. In this work, we generated a geodetic time series spanning six decades over 79 glaciers surrounding Mt. Everest and found consistent acceleration of glacier mass loss between the 1960s (â0.23 ± 0.12 mwe aâ1) and the modern era (â0.38 ± 0.11 mwe aâ1 from 2009 to 2018). Glacier mass loss has varied depending on glacier terminus type and surface characteristics, and glacier thinning is now occurring at extreme altitudes (>6,000 masl). Our time series also captures the first documented surge of a glacier in the Mt. Everest region. These multi-decadal observations of glacier mass loss form a baseline dataset against which physically based glacier evolution models could be calibrated before they are used for predicting future meltwater yield.Publisher PDFPeer reviewe
The Surface Compositions of Triton, Pluto, and Charon
Neptune's satellite Triton, and the planet-satellite binary Pluto and Charon, are the most distant planetary bodies on which ices have been directly detected. Triton and Pluto have very similar dimensions and mean densities, suggesting a similar or common origin. Through earth-based spectroscopic observations in the near-infrared, solid N2, CH4, and CO have been found on both bodies, with the additional molecule C02 on Triton. N2 dominates both surfaces, although the coverage is not spatially uniform. On Triton, the CH4 and CO are mostly or entirely frozen in the N2 matrix, while CO2 may be spatially segregated. On Pluto, some CH4 and the CO are frozen in the N2 matrix, but there is evidence for additional CH4 in a pure state, perhaps lying as a lag deposit on a subsurface layer of N2. Despite their compositional and dimensional similarities, Pluto and Triton are quite different from one another in detail. Additional hydrocarbons and other volatile ices have been sought spectroscopically but not yet have been detected. The only molecule identified on Pluto's satellite Charon is solid H2O, but the spectroscopic data are of low precision and admit the presence of other ices such as CH4
The Surfaces of Pluto and Charon
Much of the surface of Pluto consists of high-albedo regions covered to an unknown depth by Beta-N2, contaminated with CH4, CO, and other molecules. A portion of the exposed surface appears to consist of solid H2O. The remainder is covered by lower albedo material of unknown composition. The N2 ice may occur as polar caps of large extent, leaving ices and other solids of lower volatility in the equatorial regions. The low-albedo material found primarily in the equatorial regions may consist in part of solid hydrocarbons and nitriles produced from N2 and CH4 in the atmosphere or in the surface ices. Alternatively, it may arise from deposition from impacting bodies and/or the chemistry of the impact process itself. Charon's surface is probably more compositionally uniform than that of Pluto, and is covered by H2O ice with possible contaminants or exposures of other materials that are as yet unidentified. The molecular ices discovered on Pluto and Charon have been identified from near-infrared spectra obtained with Earth-based telescopes. The quantitative interpretation of those data has been achieved through the computation of synthetic spectra using the Hapke scattering theory and the optical constants of various ices observed in the laboratory. Despite limitations imposed by the availability of laboratory data on ices in various mixtures, certain specific results have been obtained. It appears that CH4 and CO are trace constituents, and that some fraction of the CH4 (and probably the CO) on Pluto is dissolved in the matrix of solid N2. Pure CH4 probably also occurs on Pluto's surface, allowing direct access to the atmosphere. Study of the nitrogen absorption band at 2.148 micrometers shows that the temperature of the N2 in the present epoch is 40 +/-2 K. The global temperature regime of Pluto can be modeled from observations of the thermal flux at far-infrared and millimeter wavelengths. The low-albedo equatorial regions must be significantly warmer than the polar regions covered by N2 (at T = 40 K) to account for the total thermal flux measured. At the present season, the diurnal skin depth of the insolation-driven thermal wave is small, and the observed mm-wave fluxes may arise from a greater depth. Alternatively, the mm-wave flux may arise from the cool, sublimation source region. The surface microstructure in the regions covered by N2 ice is likely governed by the sintering properties of this highly volatile material. The observed nitrogen infrared band strength requires that expanses of the surface be covered with cm-sized crystals of N2. Grains of H2O ice on Charon, in contrast, are probably of order 50 micrometers in size, and do not metamorphose into larger grains at a significant rate. Because of the similarities in size, density, atmosphere and surface composition between Pluto and Neptune's satellite Triton, the surface structures observed by Voyager on Triton serve as a plausible paradigm for what might be expected on Pluto. Such crater forms, tectonic structures, aeolian features, cryovolcanic structures, and sublimation-degraded topography as are eventually observed on Pluto and Charon by spacecraft will give information on their interior compositions and structures, as well as on the temperature and wind regimes over the planet's extreme seasonal cycle
Integrated system for temperature-controlled fast protein liquid chromatography comprising improved copolymer modified beaded agarose adsorbents and a travelling cooling zone reactor arrangement
An integrated approach to temperature-controlled chromatography, involving copolymer
modified agarose adsorbents and a novel travelling cooling zone reactor (TCZR)
arrangement, is described. Sepharose CL6B was transformed into a thermoresponsive cation
exchange adsorbent (thermoCEX) in four synthetic steps: (i) epichlorohydrin activation; (ii)
amine capping; (iii) 4,4âČ-azobis(4-cyanovaleric acid) immobilization; and âgraft fromâ
polymerization of poly(N-isopropylacrylamide-co-N-tert-butylacrylamide-co-acrylic acid-co-
N,NâČ-methylenebisacrylamide). FT-IR, 1H NMR, gravimetry and chemical assays allowed
precise determination of the adsorbentâs copolymer composition and loading, and identified
the initial epoxy activation step as a critical determinant of âon-supportâ copolymer loading,
and in turn, protein binding performance. In batch binding studies with lactoferrin,
thermoCEXâs binding affinity and maximum adsorption capacity rose smoothly with
temperature increase from 20 to 50 ÂșC. In temperature shifting chromatography experiments
employing thermoCEX in thermally-jacketed columns, 44 â 51% of the lactoferrin adsorbed
at 42 ÂșC could be desorbed under binding conditions by cooling the column to 22 ÂșC, but the
elution peaks exhibited strong tailing. To more fully exploit the potential of thermoresponsive
chromatography adsorbents, a new column arrangement, the TCZR, was developed. In TCZR
chromatography, a narrow discrete cooling zone (special assembly of copper blocks and
Peltier elements) is moved along a bespoke fixed-bed separation columnfilled with stationary
phase. In tests with thermoCEX, it was possible to recover 65% of the lactoferrin bound at 35
ÂșC using 8 successive movements of the cooling zone at a velocity of 0.1 mm/s; over half of
the recovered protein was eluted in the first peak in more concentrated form than in the feed.
Intra-particle diffusion of desorbed protein out of the support pores, and the ratio between the
velocities of the cooling zone and mobile phase were identified as the main parameters
affecting TCZR performance. In contrast to conventional systems, which rely on cooling the
3
whole column to effect elution and permit only batch-wise operation, TCZR chromatography
generates sharp concentrated elution peaks without tailing effects and appears ideally suited
for continuous operation
Control of translation elongation in health and disease.
Regulation of protein synthesis makes a major contribution to post-transcriptional control pathways. During disease, or under stress, cells initiate processes to reprogramme protein synthesis and thus orchestrate the appropriate cellular response. Recent data show that the elongation stage of protein synthesis is a key regulatory node for translational control in health and disease. There is a complex set of factors that individually affect the overall rate of elongation and, for the most part, these influence either transfer RNA (tRNA)- and eukaryotic elongation factor 1A (eEF1A)-dependent codon decoding, and/or elongation factor 2 (eEF2)-dependent ribosome translocation along the mRNA. Decoding speeds depend on the relative abundance of each tRNA, the cognate:near-cognate tRNA ratios and the degree of tRNA modification, whereas eEF2-dependent ribosome translocation is negatively regulated by phosphorylation on threonine-56 by eEF2 kinase. Additional factors that contribute to the control of the elongation rate include epigenetic modification of the mRNA, coding sequence variation and the expression of eIF5A, which stimulates peptide bond formation between proline residues. Importantly, dysregulation of elongation control is central to disease mechanisms in both tumorigenesis and neurodegeneration, making the individual key steps in this process attractive therapeutic targets. Here, we discuss the relative contribution of individual components of the translational apparatus (e.g. tRNAs, elongation factors and their modifiers) to the overall control of translation elongation and how their dysregulation contributes towards disease processes
Eukaryotic elongation factor 2 kinase activity is required for the phenotypes of the Rpl24Bst mouse
No abstract available
Intervalley coherence and intrinsic spin-orbit coupling in rhombohedral trilayer graphene
Rhombohedral graphene multilayers provide a clean and highly reproducible
platform to explore the emergence of superconductivity and magnetism in a
strongly interacting electron system. Here, we use electronic compressibility
and local magnetometry to explore the phase diagram of this material class in
unprecedented detail. We focus on rhombohedral trilayer in the quarter metal
regime, where the electronic ground state is characterized by the occupation of
a single spin and valley isospin flavor. Our measurements reveal a subtle
competition between valley imbalanced (VI) orbital ferromagnets and intervalley
coherent (IVC) states in which electron wave functions in the two momentum
space valleys develop a macroscopically coherent relative phase. Contrasting
the in-plane spin susceptibility of the IVC and VI phases reveals the influence
of graphene's intrinsic spin-orbit coupling, which drives the emergence of a
distinct correlated phase with hybrid VI and IVC character. Spin-orbit also
suppresses the in-plane magnetic susceptibility of the VI phase, which allows
us to extract the spin-orbit coupling strength of eV for
our hexagonal boron nitride-encapsulated graphene system. We discuss the
implications of finite spin-orbit coupling on the spin-triplet superconductors
observed in both rhombohedral and twisted graphene multilayers
Isotopes of nitrogen on Mars: Atmospheric measurements byâCuriosity's mass spectrometer
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102173/1/wong_readme.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102173/2/wong2013_SM_v4b.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/102173/3/grl51166.pd
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