The Resonance Overlap and Hill Stability Criteria Revisited

We review the orbital stability of the planar circular restricted three-body problem, in the case of massless particles initially located between both massive bodies. We present new estimates of the resonance overlap criterion and the Hill stability limit, and compare their predictions with detailed dynamical maps constructed with N-body simulations. We show that the boundary between (Hill) stable and unstable orbits is not smooth but characterized by a rich structure generated by the superposition of different mean-motion resonances which does not allow for a simple global expression for stability. We propose that, for a given perturbing mass $m_1$ and initial eccentricity $e$, there are actually two critical values of the semimajor axis. All values $a a_{\rm unstable}$ are unstable in the Hill sense. The first limit is given by the Hill-stability criterion and is a function of the eccentricity. The second limit is virtually insensitive to the initial eccentricity, and closely resembles a new resonance overlap condition (for circular orbits) developed in terms of the intersection between first and second-order mean-motion resonances.Comment: 33 pages, 14 figures, accepte

Development of an Integrated Governance Strategy for the Voluntary and Community Sector

This report on governance provides a framework for thinking about how policy makers, funders,regulators and advisers can all work with Board members and staff to enhance the effectiveness of nonprofit organisations. It was commissioned by the Active Community Unit (ACU) of the Home Office, in parallel with other reviews designed to improve the capacity of the voluntary and community sector, at a time when the sector plays an increasingly important role in the delivery of services using public funds. That role has recently been investigated in two Government reports, the Cross Cutting Review carried out by the Treasury, and the Strategy Unit review of charities and nonprofits. Our report proposes actions of three types: some that can be taken immediately, some that require further discussion with key interests, and some integration with the other ACU reviews. Taken together they provide the starting point for an evolving strategy to improve governance across the sector. We recommend ACU chairs a group charged with the responsibility for planning and implementing this. Our focus is on governance as 'the systems and processes concerned with ensuring the overall direction, supervision and accountability of an organisation'. This is often taken to mean the way that a Board, management committee or other governing body steers the overall development of an organisation, where day-to-day management is in the hands of staff or volunteers. Sometimes, of course, the committee and volunteers are the same. They – like all governing bodies – have to balance the interests of the organisation and those they are trying to serve, while being conscious of financial and legal responsibilities, and the requirements of funders and other supporters

THE FEDERAL AGRICULTURE IMPROVEMENT AND REFORM ACT OF 1996: COMMODITY AND CONSERVATION PROGRAMS

The Federal Agriculture Improvement and Reform Act contains major revisions in farm commodity programs. This paper summarizes the major provision of legislation. Because many program implementation rules must be developed, program participants are advised to consult their local office of the USDA Farm Service Agency for final program provisions.Agricultural and Food Policy,

A PREVIEW OF THE 1996 FARM PROGRAM PROVISIONS

The U.S. House of Representatives and Senate have written farm bills that contain major revisions in farm commodity programs. Differences in these bills, House bill HR 2854 and Senate bill S 1541, must now be resolved by a Conference Committee, approved by a final vote of both houses of Congress, and signed by the President. Though differences in the bills do exist, the bills contain many similar provisions that appear likely to be included in the final version of the bill. This paper summarizes the major provisions of these bills and identifies areas where differences must be resolved by the Conference Committee.Agricultural and Food Policy,

Physics of Quantum Relativity through a Linear Realization

The idea of quantum relativity as a generalized, or rather deformed, version of Einstein (special) relativity has been taking shape in recent years. Following the perspective of deformations, while staying within the framework of Lie algebra, we implement explicitly a simple linear realization of the relativity symmetry, and explore systematically the resulting physical interpretations. Some suggestions we make may sound radical, but are arguably natural within the context of our formulation. Our work may provide a new perspective on the subject matter, complementary to the previous approach(es), and may lead to a better understanding of the physics.Comment: 27 pages in Revtex, no figure; proof-edited version to appear in Phys.Rev.

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells

Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression. However, the long-sustained conviction that senescence is a truly irreversible process has recently been challenged. Still, it is not known whether cells driven into OIS can progress to cancer and thereby pose a potential threat. Here, we show that prolonged expression of the melanoma oncogene N-RAS61K in pigment cells overcomes OIS by triggering the emergence of tumor-initiating mononucleated stem-like cells from senescent cells. This progeny is dedifferentiated, highly proliferative, anoikis-resistant and induces fast growing, metastatic tumors. Our data describe that differentiated cells, which are driven into senescence by an oncogene, use this senescence state as trigger for tumor transformation, giving rise to highly aggressive tumor-initiating cells. These observations provide the first experimental in vitro evidence for the evasion of OIS on the cellular level and ensuing transformation