Intercity interactions: evidence from the US

Using national level input-output matrices, we propose a strategy to identify pecuniary externalities operating through the markets for intermediate goods at the local level. Then, controlling for common shocks in a spatial econometric framework, (i) we estimate the e®ect of pecuniary externalities on productivity growth; (ii) we disentangle such e®ect from the one of other local interactions (i.e. knowledge or other face-to-face spillovers) and that of local characteristics; (iii) we evaluate the scope of operating of all kind of externalities using di®erent distance measures. Our estimates suggest that pecuniary externalities and other kinds of local interactions coexist, that their e®ect on productivity growth is decreasing with distance and that it depends on inter-city diversity and the pattern of local specialisationcustomer and supplier driven externalities, spatial autoregressive models, dynamic factors model

Botulinum toxin therapy: functional silencing of salivary disorders.

Botulinum toxin (BTX) is a neurotoxic protein produced by Clostridium botulinum, an anaerobic bacterium. BTX therapy is a safe and effective treatment when used for functional silencing of the salivary glands in disorders such as sialoceles and salivary fistulas that may have a post-traumatic or post-operative origin. BTX injections can be considered in sialoceles and salivary fistulas after the failure of or together with conservative treatments (e.g. antibiotics, pressure dressings, or serial aspirations). BTX treatment has a promising role in chronic sialadenitis. BTX therapy is highly successful in the treatment of gustatory sweating (Frey\u2019s syndrome), and could be considered the gold standard treatment for this neurological disorder

Changes in transport and non transport costs: local vs. global impacts in a spatial network

We develop a multi-country Dixit-Stiglitz trade model and analyze how industry location and welfare respond to changes in: (i) transport frictions (e.g., infrastructure, transportation technology); and (ii) non-transport frictions (e.g., tariffs, standards and regulations). We show that changes in non-transport frictions, which are usually origin-destination specific, do not allow for any clear prediction as to changes in industry location and welfare; whereas changes in transport frictions, which are usually not origin-destination specific, may allow for such predictions. In particular, we show that reductions in transport frictions occurring at links around which the spatial network is locally a tree are Pareto welfare improving.trade frictions; multi-country trade models; monopolistic competition; spatial networks; international integration

Direct dynamics of 2D cable-driven parallel robots including cables mass effect and its influence in the control performance

Cable-driven parallel robots are a type of parallel manipulators where rigid links are replaced by actuated cables. Although in many cases dynamic models that neglect the cables mass and elasticity are employed to simulate the robot behavior and test the control approach to be used, there are several situations in which their effect cannot be disregarded, especially when large span cables are used, and the cable mass density generates important cable sagging. This work proposes a dynamic model for planar cable-driven parallel robots with 3 degrees-of-freedom considering cables mass and elasticity. Furthermore, the effect of using control approaches based on massless inelastic cables dynamic models on robots with non-negligible cable mass and elasticity is finally assessed

Prognostic significance of serine-phosphorylated STAT3 expression in pT1-T2 oral tongue carcinoma

Objectives. Phosphorylated (activated) STAT3 (pSTAT3) is a regulator of numerous genes that play an essential part in the onset, development and progression of cancer; it is involved in cell proliferation and preventing apoptosis, and in invasion, angiogenesis, and the evasion of immune surveillance. This study aimed mainly to investigate the potential prognostic role of pSTAT3 expression in oral tongue squamous cell carcinoma (SCC). Methods. Phospho-ser727 STAT3 immunolabeling was correlated with prognostic parameters in 34 consecutive cases of pT1\u2013T2 tongue SCCs undergoing primary surgery. Computer-based image analysis was used for the immunohistochemical reactions analysis. Results. Statistical analysis showed a difference in disease-free survival (DFS) when patients were stratified by pN status (P=0.031). Most tumors had variable degrees (mean\ub1SD, 80.7%\ub123.8%) of intense nuclear immunoreaction to pSTAT3. Our findings rule out any significant association of serine-phosphorylated nuclear STAT3 expression with tumor stage, grade, lymph node metastasis, recurrence rate, or DFS. Conclusion. In spite of these results, it is worth further investigating the role of pSTAT3 (serine-and tyrosine-pSTAT3) in oral tongue SCC in larger series because preclinical models are increasingly showing that several anticancer strategies would benefit from STAT3 phosphorylation inhibition

Complementary Use of Ground-Based Proximal Sensing and Airborne/Spaceborne Remote Sensing Techniques in Precision Agriculture: A Systematic Review

As the global population continues to increase, projected to reach an estimated 9.7 billion people by 2050, there will be a growing demand for food production and agricultural resources. Transition toward Agriculture 4.0 is expected to enhance agricultural productivity through the integration of advanced technologies, increase resource efficiency, ensure long-term food security by applying more sustainable farming practices, and enhance resilience and climate change adaptation. By integrating technologies such as ground IoT sensing and remote sensing, via both satellite and Unmanned Aerial Vehicles (UAVs), and exploiting data fusion and data analytics, farming can make the transition to a more efficient, productive, and sustainable paradigm. The present work performs a systematic literature review (SLR), identifying the challenges associated with UAV, Satellite, and Ground Sensing in their application in agriculture, comparing them and discussing their complementary use to facilitate Precision Agriculture (PA) and transition to Agriculture 4.0

Reactive Metals as Energy Storage and Carrier Media: Use of Aluminum for Power Generation in Fuel Cell-Based Power Plants

In recent years, the energy production sector has experienced a growing interest in new energy vectors enabling energy storage and, at the same time, intersectoral energy applications among users. Hydrogen is one of the most promising energy storage and carrier media featuring a very high gravimetric energy density, but a rather low volumetric energy density. To this regard, this study focuses on the use of aluminum as energy storage and carrier medium, offering high volumetric energy density (23.5 kWh L$^{-1}$), ease to transport and stock (e.g., as ingots), and is neither toxic nor dangerous when stored. In addition, mature production and recycling technologies exist for aluminum. Herein, the performance of power systems driven by aluminum powder in terms of electrical efficiency (η$_{(I)}$) and round‐trip efficiency (RTE) is analyzed. Along with the additional advantages relating to high volumetric energy density, and safety and management aspects, the aluminum‐based technology appears to outperform the power‐to‐power systems based on hydrogen and liquid fuels

Synchrotron radiation photoemission spectroscopy of the oxygen modified CrCl3 surface

We investigate the experimentally challenging CrCl3 surface by photon energy dependent photoemission (PE). The core and valence electrons after cleavage of a single crystal, either in a ultra-high vacuum (UHV) or in air, are studied by keeping the samples at 150 degrees C, aiming at confirming the atomic composition with respect to the expected bulk atomic structure. A common spectroscopic denominator revealed by data is the presence of a stable, but only partially ordered Cl-O-Cr surface. The electronic core levels (Cl 2p, Cr 2p and 3p), the latter ones of cumbersome component determination, allowed us to quantify the electron charge transfer to the Cr atom as a net result of this modification and the increased exchange interaction between metal and ligand atoms. In particular, the analysis of multiplet components by the CMT4XPS code evidenced the charge transfer to be favored, and similarly the reduced crystal field due to the established polarization field. Though it is often claimed that a significant amount of Cl and Cr atomic vacancies has to be included, such a possibility can be excluded on the basis of the sign and the importance of the shift in the binding energy of core level electrons. The present methodological approach can be of great impact to quantify the structure of ordered sub-oxide phases occurring in mono or bi-layer Cr trihalides

Therapeutic sequences in patients with grade 1−2 neuroendocrine tumors (NET): an observational multicenter study from the ELIOS group

Purpose: Many different treatments are suggested by guidelines to treat grade 1−2 (G1−G2) neuroendocrine tumors (NET). However, a precise therapeutic algorithm has not yet been established. This study aims at identifying and comparing the main therapeutic sequences in G1−G2 NET. Methods: A retrospective observational Italian multicenter study was designed to collect data on therapeutic sequences in NET. Median progression-free survival (PFS) was compared between therapeutic sequences, as well as the number and grade of side effects and the rate of dose reduction/treatment discontinuation. Results: Among 1182 patients with neuroendocrine neoplasia included in the ELIOS database, 131 G1–G2 gastroenteropancreatic, lung and unknown primary NET, unresectable or persistent/relapsing after surgery, treated with ≥2 systemic treatments, were included. Four main therapeutic sequences were identified in 99 patients: (A) somatostatin analogs (SSA) standard dose to SSA high dose (n = 36), (B) SSA to everolimus (n = 31), (C) SSA to chemotherapy (n = 17), (D) SSA to peptide receptor radionuclide therapy (PRRT) (n = 15). Median PFS of the second-line treatment was not reached in sequence A, 33 months in sequence B, 20 months in sequence C, 30 months in sequence D (p = 0.16). Both total number and severity of side effects were significantly higher in sequences B and C than A and D (p = 0.04), as well as the rate of dose reduction/discontinuation (p = 0.03). Conclusions: SSA followed by SSA high dose, everolimus, chemotherapy or PRRT represent the main therapeutic sequences in G1−G2 NET. Median PFS was not significantly different between sequences. However, the sequences with SSA high dose or PRRT seem to be better tolerated than sequences with everolimus or chemotherapy