633 research outputs found
The right to gender recognition before the Colombian constitutional court: a queer and travesti theory analysis
This article discusses the case-law on gender recognition of the ColombianConstitutional Court. It argues that the Court, paying attention to queerand trans theory and to the demands of trans activists, has interpretedmainstream constitutional rights in such a way that trans people can havetheir self-defined identities recognised. The article criticises the limitationsof this case-law, which still does not explicitly include non-binary andgender fluid people. On the other hand, it highlights that the Court’s doc-trine has the potential to challenge both the gender binary and the verycategory of ‘sex’ or ‘gender’ in the law
Controlling the charge transfer flow at the graphene/pyrene-nitrilotriacetic acid interface
The fabrication of highly efficient bio-organic nanoelectronic devices is still a challenge due to the difficulty in interfacing the biomolecular component to the organic counterparts. One of the ways to overcome this bottleneck is to add a self-assembled monolayer (SAM) in between the electrode and the biological material. The addition of a pyrene-nitrilotriacetic acid layer to a graphene metal electrode enhances the charge transfer within the device. Our theoretical calculations and electrochemical results show that the formation of a pyrene-nitrilotriacetic acid SAM enforces a direct electron transfer from graphene to the SAM, while the addition of the Ni2+ cation and imidazole reverses the charge transfer direction, allowing an atomic control of the electron flow, which is essential for a true working device. © 2018 The Royal Society of Chemistry
Pharmacoeconomic analysis and the appropriate use of Imatinib Mesylate in the Piedmont region
Evidence for Strong and Weak Phenyl-C61-Butyric Acid Methyl Ester Photodimer Populations in Organic Solar Cells
In polymer/fullerene organic solar cells, the photochemical dimerization of phenyl-C61-butyric acid methyl ester (PCBM) was reported to have either a beneficial or a detrimental effect on device performance and stability. In this work, we investigate the behavior of such dimers by measuring the temperature dependence of the kinetics of PCBM de-dimerization as a function of prior light intensity and duration. Our data reveal the presence of both “weakly” and “strongly” bound dimers, with higher light intensities preferentially generating the latter. DFT simulations corroborate our experimental findings and suggest a distribution of dimer binding energies, correlated with the orientation of the fullerene tail with respect to the dimer bonds on the cage. These results provide a framework to rationalize the double-edged effects of PCBM dimerization on the stability of organic solar cells
Molecular Interaction Fields vs. Quantum-Mechanical-based descriptors in the modelling of lipophilicity of platinum(IV) complexes
Metastatic colorectal cancer prior to expanded RAS assessment: Evidence from long-term outcome analysis of a real-life cohort within a dedicated colorectal cancer unit
Pt(IV)Ac-POA: new platinum compound Induced caspase independent apoptosis In B50 neuroblastoma stem cells
Neuroblastoma is a tumour that affects adults and children, characterized by a stem cells component. To date, cisplatin is
the main antitumor agent used in the clinical treatment of this tumour; however, it induces side effects such as neurotoxicity in healthy cells and induces chemo resistance to therapy in cancer cells. New platinum-based compounds, platinum (II) have recently been synthesized, and due to their chemical characteristics, they are able to identify new cellular targets. These complexes act as prodrugs and performing their cytotoxic effect as platinum (II) after a reduction reaction within the hypoxic tumour cells. Among these prodrugs, Pt(IV)Ac-POA appears to be very promising, thanks to the presence of ligand (2 propinyl)octanoic acid (POA), which acts as an inhibitor of histone deacetylase (HDACi) and leads to the increase of histone acetylation, decreasing the interactions between histone and DNA, so as to produce chemo-sensitization to DNA-damaging agents. The greater cytotoxic effect of Pt(IV)Ac-POA on tumour cells, would therefore be mainly due to the mechanism of inhibition of histone deacetylase, which would increase the accessibility of DNA to platination mechanisms that induce cell death. In this study the results show that Pt(IV)Ac-POA, used at a concentration ten times lower than cisplatin, can induce apoptosis in B50 cells in culture both through the intrinsic pathway and through the independent caspase pathway. The data, obtained by immunohistochemical techniques in fluorescence microscopy, show that treatment with Pt(IV)Ac-POA has a greater proapoptotic effect on stem cells compared to the cisplatin standard treatment
Light-induced reversible modification of the work function of a new perfluorinated biphenyl azobenzene chemisorbed on Au (111)
This work was financially supported by EC through the Marie-Curie ITN SUPERIOR (PITN-GA-2009-238177) and IEF MULTITUDES (PIEF-GA-2012-326666), the ERC project SUPRAFUNCTION (GA-257305), the Agence Nationale de la Recherche through the LabEx project Chemistry of Complex Systems (ANR-10-LABX-0026_CSC), and the International Center for Frontier Research in Chemistry (icFRC). The work in Mons is further supported by the Interuniversity Attraction Poles Programme (P7/05) initiated by the Belgian Science Policy Office, and by the Belgian National Fund for Scientific Research (FNRS). J.C. is an FNRS research director. The synthesis team in Switzerland acknowledges financial support by the Swiss National Science Foundation (SNF) and the Swiss Nanoscience Institute (SNI)
Individuality and universality in the growth-division laws of single E. coli cells
The mean size of exponentially dividing E. coli cells cultured in different
nutrient conditions is known to depend on the mean growth rate only. However,
the joint fluctuations relating cell size, doubling time and individual growth
rate are only starting to be characterized. Recent studies in bacteria (i)
revealed the near constancy of the size extension in a single cell cycle (adder
mechanism), and (ii) reported a universal trend where the spread in both size
and doubling times is a linear function of the population means of these
variables. Here, we combine experiments and theory and use scaling concepts to
elucidate the constraints posed by the second observation on the division
control mechanism and on the joint fluctuations of sizes and doubling times. We
found that scaling relations based on the means both collapse size and
doubling-time distributions across different conditions, and explain how the
shape of their joint fluctuations deviates from the means. Our data on these
joint fluctuations highlight the importance of cell individuality: single cells
do not follow the dependence observed for the means between size and either
growth rate or inverse doubling time. Our calculations show that these results
emerge from a broad class of division control mechanisms (including the adder
mechanism as a particular case) requiring a certain scaling form of the
so-called "division hazard rate function", which defines the probability rate
of dividing as a function of measurable parameters. This gives a rationale for
the universal body-size distributions observed in microbial ecosystems across
many microbial species, presumably dividing with multiple mechanisms.
Additionally, our experiments show a crossover between fast and slow growth in
the relation between individual-cell growth rate and division time, which can
be understood in terms of different regimes of genome replication control.Comment: 39 pages, 7 main figures, 17 supplementary figure
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