Male vs Female Lupus. A comparison of ethnicity, clinical features, serology and outcome over a 30 year period

Un estudi observacional de pacients amb LES, atesos al University College de London Hospital entre 1976 i 2005, es va dur a terme per revisar les diferències entre homes i dones amb lupus pel que fa a les característiques clíniques, serologia i resultats. 439 dones i 45 homes van ser identificats. L'edat mitjana al diagnòstic va ser de 29,3 anys (12,6), sense diferències significatives entre homes i dones. El sexe femení es va associar significativament amb la presència d'úlceres orals i Ig M ACA. No hi va haver diferències significatives en la comparació de les altres variables. Durant aquest període de seguiment de trenta anys, relativament poques diferències han sorgit al comparar les freqüències de les característiques clíniques i serològiques en homes y dones amb lupus.An observational study of SLE patients, seen at the University College of London Hospital between 1976 and 2005, was performed to review the differences between male and female lupus patients with respect to clinical features, serology and outcome. 439 females and 45 males were identified. Their mean age at diagnosis was 29.3 years (12.6) with no significant differences between men and women. Female gender was significantly associated with the presence of oral ulcers and Ig M ACA. There were no significant differences in the comparison of other variables. Over this thirty year follow up period, relatively few differences have emerged comparing the frequencies of clinical and serological features or outcome in male and female lupus patients

Replication of recently identified systemic lupus erythematosus genetic associations: a case–control study

Introduction We aimed to replicate association of newly identified systemic lupus erythematosus (SLE) loci. Methods We selected the most associated SNP in 10 SLE loci. These 10 SNPs were analysed in 1,579 patients with SLE and 1,726 controls of European origin by single-base extension. Comparison of allele frequencies between cases and controls was done with the Mantel–Haenszel approach to account for heterogeneity between sample collections. Results A previously controversial association with a SNP in the TYK2 gene was replicated (odds ratio (OR) = 0.79, P = 2.5 × 10-5), as well as association with the X chromosome MECP2 gene (OR = 1.26, P = 0.00085 in women), which had only been reported in a single study, and association with four other loci, 1q25.1 (OR = 0.81, P = 0.0001), PXK (OR = 1.19, P = 0.0038), BANK1 (OR = 0.83, P = 0.006) and KIAA1542 (OR = 0.84, P = 0.001), which have been identified in a genome-wide association study, but not found in any other study. All these replications showed the same disease-associated allele as originally reported. No association was found with the LY9 SNP, which had been reported in a single study. Conclusions Our results confirm nine SLE loci. For six of them, TYK2, MECP2, 1q25.1, PXK, BANK1 and KIAA1542, this replication is important. The other three loci, ITGAM, STAT4 and C8orf13-BLK, were already clearly confirmed. Our results also suggest that MECP2 association has no influence in the sex bias of SLE, contrary to what has been proposed. In addition, none of the other associations seems important in this respectThe present work was supported by Fondo de Investigacion Sanitaria of the Instituto de Salud Carlos III (Spain), grants 04/1651 and 06/0620 that are partially financed by the Fondo Europeo de Desarrollo Regional program of the European Union, by grants from the Xunta de Galicia, and by BMBF KN Rheuma grant C2.12 (to TW)S

Urinary Neuropilin-1 (NRP-1) as a prognostic marker for nephritis and lupus nephritis

La presente invención se refiere a los métodos para predecir el progreso de nefritis y nefritis lúpica en un individuo. La presente invención también se refiere a los métodos para evaluar el desarrollo de la nefritis, particularmente la nefritis lúpica, en un individuo y su respuesta a un tratamiento.Peer reviewedConsejo Superior de Investigaciones Científicas (España), Fundació Hospital Universitari Vall d'Hebron - Institut de recercaA1 Solicitud de patente con informe sobre el estado de la técnic

Urinary Neuropilin-1 (NRP-1) as a prognostic marker for nephritis and lupus nephritis

La presente invención se refiere a los métodos para predecir el progreso de nefritis y nefritis lúpica en un individuo. La presente invención también se refiere a los métodos para evaluar el desarrollo de la nefritis, particularmente la nefritis lúpica, en un individuo y su respuesta a un tratamiento.Peer reviewedConsejo Superior de Investigaciones Científicas (España), Fundació Hospital Universitari Vall d'Hebron - Institut de recercaB1 Patente sin examen previ