632 research outputs found
Akute myeloische Leukämie mit rekurrenten chromosomalen Translokationen, Analyse der Fusionsproteine und kooperierender molekularer Mutationen auf dem Weg zu einer zielgerichteten, personalisierten Therapie
Akute myeloische Leukämie mit rekurrenten chromosomalen Translokationen, Analyse der Fusionsproteine und kooperierender molekularer Mutationen auf dem Weg zu einer zielgerichteten, personalisierten Therapie
DIY Beef: Why Some Montana Ranchers Are Gambling On Direct Marketing
Ranchers in Montana direct market their cattle for several reasons, but many have done so to relieve their dependence on the national beef market, which critics claim is unfairly controlled by a consolidated packing industry. Pandemic-related disruptions to the U.S. meat supply chain created uncertainty and exposed vulnerabilities for producers and consumers that drove a renewed interest in direct-marketed beef. Casey Buffington ranches near Chester, MT, and began direct marketing his cattle in 2019 to assert more control over his market and create more profit for his ranch. In telling Buffington’s story, this narrative explores how beneficial direct marketing can be to ranchers, as well as the factors that constrain direct marketing, such as the scarcity of available processing and lack of a robust local market. Investments by the Biden administration seek to build new meat processing facilities in the state, shortening the amount of travel ranchers like Buffington must make to access processing, and some ranchers have taken advantage of online sales and delivery routes to expand their markets in the state
Assessing Contributions of Atlantic's Projects to Improving Care for Vulnerable Elders
Assesses the impact of Atlantic's Human Capital Development in Aging grants on outcomes and the field, and lessons on fellowship award, training, and single model programs; scaling models; infrastructure and development; and policy and advocacy
(Z)-Amino(2-methyl-3-oxoisoindolin-1-ylidene)acetonitrile
The asymmetric unit of the title compound, C11H9N3O, contains two independent and nearly identical molecules (A and B). Molecule A can be transformed to B using a rotation of approximately 85° around the [111] direction. Each A molecule is connected to three B molecules via N—H⋯N and N—H⋯O hydrogen bonds and vice versa. Centrosymmetrically related molecules of the same residue form π–π interactions with centroid–centroid distances of 4.326 (1) and 3.826 (1) Å for the benzene rings of molecules A and B, respectively
The Evolution from Mentor Texts to Critical Mentor Text Sets
This article chronicles how two teacher educators changed the mentor text set assignment--one component of a larger writing unit plan--from a simple list of texts to a critical mentor text set that includes intentionally selected, culturally and linguistically diverse texts. The goal of the critical mentor text set was to support preservice teachers’ understanding of how to implement culturally sustaining writing pedagogy through developing students’ identities, skills, and intellect as writers, and students’ abilities to read texts through a critical stance that evaluates the privilege and power within the texts while working towards anti-oppression
A visible light-driven Minisci-type reaction with N-hydroxyphthalimide esters
A visible light-promoted protocol for the redox-neutral coupling of N-hydroxyphthalimide esters with different n-heterocyclic compounds is described. the reaction proceeds through an alkyl radical intermediate generated by reductive decarboxylation of n-hydroxyphthalimide esters. in contrast to the original minisci protocol, polyalkylation can largely be avoided. mechanistic investigations revealed a radical chain mechanism which in some cases can proceed even if no photocatalyst is added. this valuable and functional group-tolerant reaction produces substituted heterocycles in moderate to excellent yield. the use of inexpensive starting materials and leds as the light source are key features of this c–c bond formation
Subplate Cells: Amplifiers of Neuronal Activity in the Developing Cerebral Cortex
Due to their unique structural and functional properties, subplate cells are ideally suited to function as important amplifying units within the developing neocortical circuit. Subplate neurons have extensive dendritic and axonal ramifications and relatively mature functional properties, i.e. their action potential firing can exceed frequencies of 40 Hz. At earliest stages of corticogenesis subplate cells receive functional synaptic inputs from the thalamus and from other cortical and non-cortical sources. Glutamatergic and depolarizing GABAergic inputs arise from cortical neurons and neuromodulatory inputs arise from the basal forebrain and other sources. Activation of postsynaptic metabotropic receptors, i.e. muscarinic receptors, elicits in subplate neurons oscillatory burst discharges which are transmitted via electrical and chemical synapses to neighbouring subplate cells and to immature neurons in the cortical plate. The tonic non-synaptic release of GABA from GABAergic subplate cells facilitates the generation of burst discharges. These cellular bursts are amplified by prominent gap junction coupling in the subplate and cortical plate, thereby eliciting 10–20 Hz oscillations in a local columnar network. Thus, we propose that neuronal networks are organized at earliest stages in a gap junction coupled columnar syncytium. We postulate that the subplate does not only serve as a transient relay station for afferent inputs, but rather as an active element amplifying the afferent and intracortical activity
rac-4-{(E)-[1-Cyano-1-cyclohexyl-2-(1H-indol-3-yl)ethyl]iminomethyl}benzonitrile
A phosphine-catalysed addition of gramine to an alkylideneaminonitrile gives the title compound, C25H24N4, in good yield. In the crystal, pairs of molecules are connected via N—H⋯N hydrogen bonds into inversion dimers. The molecules are characterized by a planar indole moiety [maximum deviation = 0.012 (1) Å], a chair conformation of the cyclohexane ring and an antiperiplanar conformation of the H atom on the cyclohexane and the adjacent cyano group
Mechanismen der Persistenz von Chlamydia trachomatis und Chlamydophila pneumoniae in humanen monozytären und epithelialen Zellen
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