Bleb formation in small unruptured intracranial aneurysm as a predictor of early rupture

Small unruptured aneurysms are thought to have a low risk of rupture, but the management of such lesions is still controversial. A 73-year-old man with a small anterior communication artery aneurysm, 4 mm in diameter, while on follow-up, developed an aneurysmal subarachnoid hemorrhage 2 weeks after the detection of a newly emerged bleb on the surface of the aneurysm. In conclusion, the formation of a bleb should be considered as a warning sign of an impending rupture, and treatment should be provided even for patients with small aneurysms

Buffer Construction Methodology in Demonstration Test For Cavern Type Disposal Facility -9182

ABSTRACT A number of studies concerning a cavern type disposal facility have been carried out for disposal of low level radioactive waste mainly generated by power plant decommissioning in Japan 1) . The disposal facility is composed of an engineered barrier system with concrete pit and bentonite buffer, and planed to be constructed in sub-surface 50 -100 meters depth. Though the previous studies have mainly used laboratory and mock-up tests, we conducted a demonstration test in a full-size cavern. The main objectives of the test were to study the construction methodology and to confirm the quality of the engineered barrier system. The demonstration test was planned as the construction of full scale mock-up. It was focused on a buffer construction test to evaluate the construction methodology and quality control in this paper. Bentonite material was compacted to 1.6 Mg/m 3 in-site by large vibrating roller in this test. Through the construction of the buffer part, a 1.6 Mg/m 3 of the density was accomplished, and the data of workability and quality is collected

Novel Oral Derivative UD-017, a Highly Selective CDK7 Inhibitor, Exhibits Anticancer Activity by Inducing Cell-Cycle Arrest and Apoptosis in Human Colorectal Cancer

Objective: This study aimed to investigate the anticancer profile of a new cyclin-dependent kinase 7 (CDK7) inhibitor, UD-017, by examining its mechanism of action using HCT-116 colorectal cancer cells. Methods: The anticancer properties of UD-017 were assessed using several assays, including in vitro kinase, proliferation, and apoptosis assays, western blot analysis, and an in vivo xenograft mouse model. Results: UD-017 significantly inhibited CDK7 activity (IC50 = 16 nM) with high selectivity in an in vitro kinase assay testing a panel of over 300 proteins and lipid kinases. UD-017 also inhibited the growth of HCT-116 cells (GI50 = 19 nM) and inhibited the phosphorylation of various downstream mediators of CDK7 signaling. In cell cycle and apoptosis assays using HCT-116 cells, UD-017 increased the number of cells in both G1 and G2/M phases and induced apoptosis. In vivo, UD-017 inhibited tumor growth in an HCT-116 xenograft mouse model by 33%, 64%, and 88% at doses of 25, 50, and 100 mg/kg, respectively, with clear dose-dependency. Co-administration of 5-FU and 50 mg/kg UD-017 had a strong synergistic effect, as reflected in the complete inhibition of tumor growth. Conclusion: CDK7 may play a major role in colorectal cancer growth by regulating the cell cycle and apoptosis. UD-017 is a promising candidate therapeutic agent for the treatment of cancer involving CDK7 signaling

Persistence of Laminar Flamelet Structure Under Highly Turbulent Combustion

We have investigated the premixed flame structure in highly turbulent flow with a cyclone-jet combustor. Based on the turbulent properties determined by Slot-Correlation method, the condition of U_m20 m/s belongs to the distributed reaction zone regime on the combustion diagram. Also, we have quantitatively estimated the reaction zone thickness, using the probability of reaction zone existing. Results show that the dependence of reaction zone thickness on equivalence ratio is very similar to those of the experimental values by Yamaoka and Tsuji or the Zeldovich thickness. When the exit velocity is increased, the reaction zone thickness is almost constant for Ka>1. Hence, the persistence of laminar flamelet structure is observed, even when the Kolmogorov scale is smaller than reaction zone thickness. It could be concluded that the reaction region remains undisturbed with thin reaction zone under highly turbulent conditions. These results are useful for modeling turbulent combustion.・rights：日本機械学会・rights：本文データは学協会の許諾に基づきCiNiiから複製したものである・relation：isVersionOf：http://ci.nii.ac.jp/naid/110003479169

Mechanism of Flame Stability in a Rotating Flow : Combustion Characteristics of Tubular Flames in a Hydrogen/Air Mixture

The effects of rotation on the stability and structure of tubular flames have been investigated for a lean hydrogen/air mixture, and mechanism of flame stability in a rotating flow has been discussed. Results show that with increasing intensity of rotation, (1) the flame diameter increases, while thickness of the luminous zone decreases, (2) the fuel concentration at the extinction decreanes, i. e., the stable region expands, (3) the radial temperature distribution becomes an M-shaped profiles, and (4) flame temperature T_f increases near extinction. These results are almost the same as those obtained for a methane/air mixture. The mechanism for these phenomena is supposed to be explained with the coupled effects of pressure diffusion and stretch effect. The present experimental results provide very useful information for discussing the flame stability and the transport phenomena in a vortex flow

Evidence for bovine immunodeficiency virus infection in cattle in Zambia

We report herein on the first evidence for presence of bovine immunodeficiency virus (BIV) in Zambia. Serological surveillance of BIV and bovine leukemia virus (BLV) was conducted in traditional cattle herds in Zambia. Out of a total of 262 sera analyzed, 11.4% were found positive for anti-BIV p26 antibodies as determined by Western blot analysis, while 5.0% were positive for anti-BLV gp51 antibodies as detected by immunodiffusion test. Peripheral blood mononuclear cells from BIV seropositive cattle were found to have BIV-provirus DNA, as detected by nested polymerase chain reaction. A nucleotide sequence corresponding to a 298 bp fragment of BIV pol gene wea also analyzed. Amino acid sequences of these Zambian pol gene products showed 98.0 to 100% homology to the American strain BIV R29, 97.0 to 99.0% to Japanese BIV isolates, and divergence ranged from 0.0 to 2.0% among Zambian BIV isolates

The Local Reaction Rate in Round-Jet Diffusion Flames

A combustion model for turbulent diffusion flames is estimated frequently through the comparison of the simulated result with the experimental one. Usually, profiles of time-averaged concentration and temperature are used in that comparison, because the local reaction rate cannot be directly measured. However, since their profiles are also influenced largely by transport phenomena, it is difficult to estimate the combustion model properly with this method. Therefore, it is desirable to calculate the local reaction rate from experimental results and compare it with the simulated one. In the present study, from this point of view, the local reaction rate was tried to obtain by numerical calculation using measured values for a hydrogen jet diffusion flame. Then, it was suggested through the comparison of the obtained result with the simulated one that the method proposed here can provide reliable values for the local reaction rate.・rights：日本機械学会・rights：本文データは学協会の許諾に基づきCiNiiから複製したものである・relation：isVersionOf：http://ci.nii.ac.jp/naid/110002981414