1,848 research outputs found

    Decoupling Farm Payments: Experience in the U.S., Canada, and Europe

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    Commodity payments in Europe and North America are production based, encouraging greater chemical use and cropping area. Thus, each region undermines the other’s price supports at the expense of the environment. Countries can, however, sever the link between yield levels and payments. Allowing farmers to exit agriculture poses challenges for the US, but perhaps not for Canada and the EU.decoupling, liberalizing trade, environment, flexibility

    Geographies of landscape aesthetics: mapping landscape terminology in digitised historical travel accounts of Loch Lomond and the Trossachs

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    This study spatially analyses aesthetic terms in historical travel accounts of the landscapes of Loch Lomond and the Trossachs from the eighteenth to the twentieth century. We applied a hybrid approach, combining qualitative methods of textual analysis with quantitative techniques of a Geographical Information System (GIS), to a corpus of 38 digitised works featuring a range of historic guidebooks and travelogues. To identify relationships between place names, landscape features and the aesthetic terms beautiful, magnificent, picturesque, romantic and sublime, we first analysed how these terms occurred together in the text. We also used digital terrain model data in GIS to explore relationships between the aesthetic terms and the elevation of place names and landscape features. The results provide evidence that the aesthetic terms magnificent and sublime were applied to describe places and landforms at higher elevations, whilst beautiful, picturesque and romantic were applied to lower-lying regions of the Loch Lomond and the Trossachs landscapes. Our findings illustrate how the cartographic capabilities of GIS, combined with text analysis, can shed light on how landscapes were historically represented in travel literature

    Earth History Visualization System

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    Time Scale Creator (TSCreator), a geological chart generator, displays any portion of Earth history including chemo- magneto-, and other aspects. TSCreator is used by many universities, petroleum companies, and international geological surveys. In order to improve the quality of Time Scale Creator, tools were developed to provide users with more friendly graphical user interfaces (GUIs), accurate scaling of specific isotope, internationalization of data input and output, and smart depth scaling in wells to age conversion. To implement such tools, research for algorithm and common methods was basically done by searching articles online and reading posts on forums for Java developers. Toggle buttons indicating moving status of time lines were inserted into the tool bar of Crossplot frame. Internationalization was improved by accepting both European and American number formats in text boxes and entries of data packs. Strontium, an isotope used to interpret rates of mountain belt uplift and continental drift, was given four decimal place precision whereas other isotopes have standard two to three decimal places precision. Finally, an algorithm for naturally dividing depth range was inserted for depth scales in Depth/ Age Conversion. The Depth-Age system will be used with university lab modules. These developed tools enhance user experience and performance of Time Scale Creator. The improvements were already used by two university workshops in China, and will be used by petroleum-exploration workshops in Australia. An article about this system is planned for publication

    Geographies of landscape aesthetics : mapping landscape terminology in digitised historical travel accounts of Loch Lomond and the Trossachs

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    Acknowledgements Ogg.: Conceptualisation, Methodology, Formal Analysis, Investigation, Visualisation, Writing –Original Draft Preparation. Wartmann.: Conceptualisation, Supervision, Writing – Review & Editing.Peer reviewedPublisher PD

    Selmer Groups in Twist Families of Elliptic Curves

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    The aim of this article is to give some numerical data related to the order of the Selmer groups in twist families of elliptic curves. To do this we assume the Birch and Swinnerton-Dyer conjecture is true and we use a celebrated theorem of Waldspurger to get a fast algorithm to compute % L_{E}(1). Having an extensive amount of data we compare the distribution of the order of the Selmer groups by functions of type α(loglog(X))1+εlog(X)\alpha \frac{(\log \log (X))^{1+\varepsilon}}{\log (X)} with ε\varepsilon small. We discuss how the "best choice" of α\alpha is depending on the conductor of the chosen elliptic curves and the congruence classes of twist factors.Comment: to appear in Quaestiones Mathematicae. 16 page

    Sensitization of tumour cells to lysis by virus-specific CTL using antibody-targeted MHC class I/peptide complexes

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    A number of cell surface molecules with specificity to tumour cells have been identified and monoclonal antibodies (mAb) to some of these antigens have been used for targeting tumour cells in vivo. We have sought to link the powerful effector mechanisms of cytotoxic T-cells with the specificity of mAb, by targeting recombinant HLA class I molecules to tumour cells using an antibody delivery system. Soluble recombinant MHC class I/peptide complexes including HLA-A2.1 refolded around an immunodominant peptide from the HIV gag protein (HLA-A2/gag) were synthesized, and the stability of these complexes at 37°C was confirmed by enzyme-linked immunosorbent assay using a conformation-specific antibody. MHC class I-negative lymphoma cells (Daudi) were labelled with a biotinylated mAb specific for a cell surface protein (anti-CD20) then linked to soluble biotinylated HLA-A2/gag complexes using an avidin bridge. Flow cytometry revealed strong labelling of lymphoma cells with HLA-A2/gag complexes (80-fold increase in mean channel fluorescence). CTL specific for HLA-A2/gag efficiently lysed complex-targeted cells, while control CTL (specific for an HLA-A2.1-restricted epitope of melan-A) did not. Similarly, SK-mel-29 melanoma cells were also efficiently lysed by HLA-A2/gag-specific CTL when HLA-A2/gag complexes were linked to their surface via the HMW-MAA specific anti-melanoma antibody 225.28s. With further consideration to the in vivo stability of the MHC class I/peptide complexes, this system could prove a new strategy for the immunological therapy of cancer. © 2000 Cancer Research Campaig

    Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury

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    Severe lung damage in COVID-19 involves complex interactions between diverse populations of immune and stromal cells. In this study, we used a spatial transcriptomics approach to delineate the cells, pathways and genes present across the spectrum of histopathological damage in COVID-19 lung tissue. We applied correlation network-based approaches to deconvolve gene expression data from areas of interest within well preserved post-mortem lung samples from three patients. Despite substantial inter-patient heterogeneity we discovered evidence for a common immune cell signaling circuit in areas of severe tissue that involves crosstalk between cytotoxic lymphocytes and pro-inflammatory macrophages. Expression of IFNG by cytotoxic lymphocytes was associated with induction of chemokines including CXCL9, CXCL10 and CXCL11 which are known to promote the recruitment of CXCR3+ immune cells. The tumour necrosis factor (TNF) superfamily members BAFF ( TNFSF13B ) and TRAIL ( TNFSF10 ) were found to be consistently upregulated in the areas with severe tissue damage. We used published spatial and single cell SARS-CoV-2 datasets to confirm our findings in the lung tissue from additional cohorts of COVID-19 patients. The resulting model of severe COVID-19 immune-mediated tissue pathology may inform future therapeutic strategies. One Sentence Summary Spatial analysis identifies IFNγ response signatures as focal to severe alveolar damage in COVID-19 pneumonitis

    Magnetic-field dependence of electron spin relaxation in n-type semiconductors

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    We present a theoretical investigation of the magnetic field dependence of the longitudinal (T1T_1) and transverse (T2T_2) spin relaxation times of conduction band electrons in n-type III-V semiconductors. In particular, we find that the interplay between the Dyakonov-Perel process and an additional spin relaxation channel, which originates from the electron wave vector dependence of the electron gg-factor, yields a maximal T2T_2 at a finite magnetic field. We compare our results with existing experimental data on n-type GaAs and make specific additional predictions for the magnetic field dependence of electron spin lifetimes.Comment: accepted for publication in PRB, minor changes to previous manuscrip
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