Constraining the Natural MSSM through tunneling to color-breaking vacua at zero and non-zero temperature

We re-evaluate the constraints on the parameter space of the minimal supersymmetric standard model from tunneling to charge- and/or color-breaking minima, taking into account thermal corrections. We pay particular attention to the region known as the Natural MSSM, where the masses of the scalar partners of the top quarks are within an order of magnitude or so of the electroweak scale. These constraints arise from the interaction between these scalar tops and the Higgs fields, which allows the possibility of parameter points having deep charge- and color-breaking true vacua. In addition to requiring that our electro-weak-symmetry-breaking, yet QCD- and electromagnetism-preserving vacuum has a sufficiently long lifetime at zero temperature, also demanding stability against thermal tunneling further restricts the allowed parameter space.Comment: 7 pages, 2 figures, software available from http://vevacious.hepforge.org/ - version 2 matches that accepted for publication in Phys. Lett.

Vevacious: A Tool For Finding The Global Minima Of One-Loop Effective Potentials With Many Scalars

Several extensions of the Standard Model of particle physics contain additional scalars implying a more complex scalar potential compared to that of the Standard Model. In general these potentials allow for charge and/or color breaking minima besides the desired one with correctly broken SU(2)_L times U(1)_Y . Even if one assumes that a metastable local minimum is realized, one has to ensure that its lifetime exceeds that of our universe. We introduce a new program called Vevacious which takes a generic expression for a one-loop effective potential energy function and finds all the tree-level extrema, which are then used as the starting points for gradient-based minimization of the one-loop effective potential. The tunneling time from a given input vacuum to the deepest minimum, if different from the input vacuum, can be calculated. The parameter points are given as files in the SLHA format (though is not restricted to supersymmetric models), and new model files can be easily generated automatically by the Mathematica package SARAH. This code uses HOM4PS2 to find all the minima of the tree-level potential, PyMinuit to follow gradients to the minima of the one-loop potential, and CosmoTransitions to calculate tunneling times.Comment: 44 pages, 1 figure, manual for publicly available software, v2 corresponds to version accepted for publication in EPJC [clearer explanation of scale dependence and region of validity, explicit mention that SLHA files should have blocks matching those expected by model files, updated references

Using generative artificial intelligence to catalyse further interdisciplinarity across higher education

An international challenge, and opportunity, facing academics in these early decades of the 21st century is the inception of complex computational machines that are capable of imitating human-like learning and thinking; often described as Artificial Intelligence, or AI. One such form of AI is generative AI (GenAI), an algorithm capable of producing text, collages and other overviews of information and data gathered from multiple online sources. This offers challenges, such as students generating and submitting essays and reports from GenAI alone, but also opportunities, as a platform for further discussion and reflection as knowledge is uncovered and developed. Of particular interest is its capability in picking up information and data from multiple fields and presenting it in a digestible and interdisciplinary initial format, albeit it typically requiring further analysis, reflection, and modification. In response to this, a new AI-focused academic journal is proposed in this study, the drive being to enhance interdisciplinarity by bringing together postgraduate students and staff to research, explore, analyse, and critically reflect upon the challenges and opportunities that AI presents in their fields of study

Certified and uncertified skills and productivity growth performance: cross-country evidence at industry level

We analyse the relationship between human capital and productivity growth using a five-country multi-industry dataset together with a measure of human capital which accounts for both certified skills (educational qualifications) and uncertified skills acquired through on-the-job training and experience. We find evidence of positive human capital effects on growth in average labour productivity, particularly when using our composite human capital measure. We also find some tentative evidence that multi-factor productivity (MFP) growth is positively related to the use of high-skilled labour. However, externalities of this kind are largely confined to industries which make intensive use of university graduates. (abstract as appears on publisher website

Total focussing method for volumetric imaging in immersion non destructive evaluation

This paper describes the use of a 550 (25x22) element 2MHz 2D piezoelectric composite array in immersion mode to image an aluminum test block containing a collection of artificial defects. The defects included a 1mm diameter side-drilled hole, a collection of 1mm slot defects with varying degrees of skew to the normal and a flat bottomed hole. The data collection was carried out using the full matrix capture; a scanning procedure was developed to allow the operation of the large element count array through a conventional 64-channel phased array controller. A 3D TFM algorithm capable of imaging in a dual media environment was implemented in MATLAB for the offline processing the raw scan data. This algorithm facilitates the creation of 3D images of defects while accounting for refraction effects at material boundaries. In each of the test samples interrogated the defects, and their spatial position, are readily identified using TFM. Defect directional information has been characterized using VTFM for defect exhibiting angles up to and including 45o of skew

Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells

A major risk factor for ovarian cancer is germline mutations of BRCA1/2. It has been found that (80%) of cellular models with acquired platinum or taxane resistance display an inverse resistance relationship, that is collateral sensitivity to the other agent. We used a clinically relevant comparative selection strategy to develop novel chemoresistant cell lines which aim to investigate the mechanisms of resistance that arise from different exposures of carboplatin and taxol on cells having BRCA1 function (UPN251) or dysfunction (OVCAR8). Resistance to carboplatin and taxol developed quicker and more stably in UPN251 (BRCA1-wildtype) compared to OVCAR8 (BRCA1-methylated). Alternating carboplatin and taxol treatment delayed but did not prevent resistance development when compared to single-agent administration. Interestingly, the sequence of drug exposure influenced the resistance mechanism produced. UPN251-6CALT (carboplatin first) and UPN251-6TALT (taxol first) have different profiles of cross resistance. UPN251-6CALT displays significant resistance to CuSO4 (2.3-fold, p=0.004) while UPN251-6TALT shows significant sensitivity to oxaliplatin (0.6-fold, p=0.01). P-glycoprotein is the main mechanism of taxol resistance found in the UPN251 taxane-resistant sublines. UPN251 cells increase cellular glutathione levels (3.0-fold, p=0.02) in response to carboplatin treatment. However, increased glutathione is not maintained in the carboplatin-resistant sublines. UPN251-7C and UPN251-6CALT are low-level resistant to CuSO4 suggesting alterations in copper metabolism. However, none of the UPN251 sublines have alterations in the protein expression of ATP7A or CTR1. The protein expression of BRCA1 and MRP2 is unchanged in the UPN251 sublines. The UPN251 sublines remain sensitive to parp inhibitors veliparib and CEP8983 suggesting that these agents are candidates for the treatment of platinum/taxane resistant ovarian cancer patients

Non-invasive and non-destructive measurements of confluence in cultured adherent cell lines

Many protocols used for measuring the growth of adherent monolayer cells in vitro are invasive, destructive and do not allow for the continued, undisturbed growth of cells within flasks. Protocols often use indirect methods for measuring proliferation. Microscopy techniques can analyse cell proliferation in a non-invasive or non-destructive manner but often use expensive equipment and software algorithms. In this method images of cells within flasks are captured by photographing under a standard inverted phase contract light microscope using a digital camera with a camera lens adaptor. Images are analysed for confluence using ImageJ freeware resulting in a measure of confluence known as an Area Fraction (AF) output. An example of the AF method in use on OVCAR8 and UPN251 cell lines is included. •Measurements of confluence from growing adherent cell lines in cell culture flasks is obtained in a non-invasive, non-destructive, label-free manner. •The technique is quick, affordable and eliminates sample manipulation. •The technique provides an objective, consistent measure of when cells reach confluence and is highly correlated to manual counting with a haemocytometer. The average correlation co-efficient from a Spearman correlation (n = 3) was 0.99 ± 0.008 for OVCAR8 (p = 0.01) and 0.99 ± 0.01 for UPN251 (p = 0.01) cell lines