A neighbourhood Output Area Classification from the 2021 and 2022 UK censuses

UK-wide multivariate neighbourhood classifications have been built using small area population data following every census since 1971, and have been built using Output Area geographies since 2001. Policy makers in both the public and private sectors find such taxonomies, typically arranged into hierarchies of Supergroups, Groups and Subgroups, useful across a wide range of applications in business and service planning. Recent and forthcoming releases of small area census statistics pose new methodological challenges. For example, the 2022 Scottish Census was carried out a year after those in other UK nations, and some of the variables now collected across different jurisdictions do not bear direct comparison with one another. Here we develop a methodology to accommodate these issues alongside the more established procedures of variable selection, standardisation, transformation, class definition and labelling

The critical role of second-order normative beliefs in predicting energy conservation

This is the author accepted manuscript. The final version is available from Springer Nature via the DOI in this recordSustaining large-scale public goods requires individuals to make environmentally friendly decisions today to benefit future generations. Recent research suggests that second-order normative beliefs are more powerful predictors of behaviour than first-order personal beliefs. We explored the role that second-order normative beliefs—the belief that community members think that saving energy helps the environment—play in curbing energy use. We first analysed a data set of 211 independent, randomized controlled trials conducted in 27 US states by Opower, a company that uses comparative information about energy consumption to reduce household energy usage (pooled N = 16,198,595). Building off the finding that the energy savings varied between 0.81% and 2.55% across states, we matched this energy use data with a survey that we conducted of over 2,000 individuals in those same states on their first-order personal and second-order normative beliefs. We found that second-order normative beliefs predicted energy savings but first-order personal beliefs did not. A subsequent pre-registered experiment provides causal evidence for the role of second-order normative beliefs in predicting energy conservation above first-order personal beliefs. Our results suggest that second-order normative beliefs play a critical role in promoting energy conservation and have important implications for policymakers concerned with curbing the detrimental consequences of climate change

A miniature bioassay for testing the acute phytotoxicity of photosystem II herbicides on seagrass

© 2015 Wilkinson et al. Photosystem II (PSII) herbicides have been detected in nearshore tropical waters such as those of the Great Barrier Reef and may add to the pressure posed by runoff containing sediments and nutrients to threatened seagrass habitats. There is a growing number of studies into the potential effects of herbicides on seagrass, generally using large experimental set-ups with potted plants. Here we describe the successful development of an acute 12-well plate phytotoxicity assay for the PSII herbicide Diuron using isolated Halophila ovalis leaves. Fluorescence images demonstrated Diuron affected the entire leaf surface evenly and responses were not influenced by isolating leaves from the plant. The optimum exposure duration was 24 h, by which time the inhibition of effective quantum yield of PSII (ΔF/Fm′) was highest and no deterioration of photosystems was evident in control leaves. The inhibition of ΔF/Fm′ by Diuron in isolated H. ovalis leaves was identical to both potted and hydroponically grown plants (with leaves remaining attached to rhizomes), indicating similar reductions in photosynthetic activity in these acute well-plate assays. The sensitivity of the assay was not influenced by irradiance (range tested 40 to 400 μmol photons m-2 s-1). High irradiance, however, caused photo-oxidative stress in H. ovalis and this generally impacted in an additive or sub-additive way with Diuron to damage PSII. The bioassay using isolated leaves is more rapid, uses far less biological material and does not rely on specialised aquarium facilities in comparison with assays using potted plants. The development and validation of this sensitive bioassay will be useful to reliably screen and monitor the phytotoxicity of existing and emerging PSII herbicides and contribute to risk assessments and water quality guideline development in the future

Innovation, dynamic capabilities and family firms operating in an emerging economy

Drawing on the dynamic capabilities framework (DCF), this exploratory study examines family firms' involvement in innovation practices, including reasons and ways to innovate. The cases of four family firms operating in an emerging economy (Uruguay) are investigated. Semi-structured, face-to-face and telephone interviews were conducted with owners and managers, and complemented with e-mail correspondence. Based on the imperative need to solve problems in their industry, firms' managements were intensively involved in various innovative processes. These processes included quality improvements, responding to a dynamic and competitive business and consumer environment, and extending the life and survival of the family enterprise for future generations. Notably, the importance of sensing and learning in the form of identifying and assimilating key information, and seizing and applying such information to develop or adopt innovation, including new technologies, emerged strongly. The findings also highlight the usefulness of the DCF to understand firms' integration, and transformation of learning. © 2018 Inderscience Enterprises Ltd

Consumer-Based Wearable Activity Trackers Increase Physical Activity Participation: Systematic Review and Meta-Analysis

Background: The range of benefits associated with regular physical activity participation is irrefutable. Despite the well-knownbenefits, physical inactivity remains one of the major contributing factors to ill-health throughout industrialized countries.Traditional lifestyle interventions such as group education or telephone counseling are effective at increasing physical activityparticipation; however, physical activity levels tend to decline over time. Consumer-based wearable activity trackers that allowusers to objectively monitor activity levels are now widely available and may offer an alternative method for assisting individualsto remain physically active.Objective: This review aimed to determine the effects of interventions utilizing consumer-based wearable activity trackers onphysical activity participation and sedentary behavior when compared with interventions that do not utilize activity trackerfeedback.Methods: A systematic review was performed searching the following databases for studies that included the use of aconsumer-based wearable activity tracker to improve physical activity participation: Cochrane Controlled Register of Trials,MEDLINE, PubMed, Scopus, Web of Science, Cumulative Index of Nursing and Allied Health Literature, SPORTDiscus, andHealth Technology Assessments. Controlled trials of adults comparing the use of a consumer-based wearable activity trackerwith other nonactivity tracker–based interventions were included. The main outcome measures were physical activity participationand sedentary behavior. All studies were assessed for risk of bias, and the Grades of Recommendation, Assessment, Development,and Evaluation system was used to rank the quality of evidence. The guidelines of the Preferred Reporting Items for SystematicReviews and Meta-Analyses statement were followed. A random-effects meta-analysis was completed on the included outcomemeasures to estimate the treatment effect of interventions that included an activity tracker compared with a control group.Results: There was a significant increase in daily step count (standardized mean difference [SMD] 0.24; 95% CI 0.16 to 0.33;PConclusions: Utilizing a consumer-based wearable activity tracker as either the primary component of an intervention or aspart of a broader physical activity intervention has the potential to increase physical activity participation. As the effects of physicalactivity interventions are often short term, the inclusion of a consumer-based wearable activity tracker may provide an effectivetool to assist health professionals to provide ongoing monitoring and support

Hypomethylation of FAM63B in bipolar disorder patients

Bipolar disorder (BD) and schizophrenia (SZ) are known to share common genetic and psychosocial risk factors. A recent epigenome-wide association study performed on blood samples from SZ patients found significant hypomethylation of FAM63B in exon 9. Here, we used iPLEX-based methylation analysis to investigate two CpG sites in FAM63B in blood samples from 459 BD cases and 268 controls. Both sites were significantly hypomethylated in BD cases (lowest p value = 3.94 × 10−8). The methylation levels at the two sites were correlated, and no strong correlation was found with nearby single nucleotide polymorphisms (SNPs), suggesting that methylation differences at these sites are not readably picked up by genome-wide association studies. Overall, FAM63B hypomethylation was found in BD patients, thus replicating the initial finding in SZ patients. This study suggests that FAM63B is a shared epigenetic risk gene for the two disorders

Older adults’ experiences of using a wearable activity tracker with health professional feedback over a 12-month randomised controlled trial

Objective:Wearable activity trackers can help older adults remain physically active. However, knowledge of the userexperience during long-term use is scarce. Therefore, this study examined older adults’ experiences with, and perceptionsof, wearable activity trackers combined with health professional feedback after a year’s use as part of a randomisedcontrolled trial.Methods: Twenty older adults (73.6 5.5 years) who had used a Jawbone UP24 activity tracker for 12 months during arandomised controlled trial were recruited for this study. All participants had at least one chronic condition. Acceptabilitydata relating to activity tracker wear time was combined with focus group data to explore participants experiences of longterm activity tracker use. Data was analysed using thematic analysis.Results: The activity tracker was well-accepted with the device worn on an average of 86% of possible days and participantsreported an overall positive experience. Four themes were identified: (a) increased sense of awareness of activity levels isrelated to motivation; (b) the level of engagement with the activity tracker influences the user experience; (c) the role offeedback from a health professional in providing ongoing support; d) the role of habits in supporting long-term behaviourchange.Conclusions: The use of an activity tracker combined with health professional support can assist older adults to maintaintheir activity levels over 12 months. Consideration should be given to the previous technology experience of users and thedesign and accuracy of an activity tracker when recommending their use in a research or clinical setting

SUPPORT Tools for evidence-informed health Policymaking (STP) 12: Finding and using research evidence about resource use and costs

This article is part of a series written for people responsible for making decisions about health policies and programmes and for those who support these decision makers

CACNA1C hypermethylation is associated with bipolar disorder

The CACNA1C gene, encoding a subunit of the L-type voltage-gated calcium channel is one of the best-supported susceptibility genes for bipolar disorder (BD). Genome-wide association studies have identified a cluster of non-coding single-nucleotide polymorphisms (SNPs) in intron 3 to be highly associated with BD and schizophrenia. The mechanism by which these SNPs confer risk of BD appears to be through an altered regulation of CACNA1C expression. The role of CACNA1C DNA methylation in BD has not yet been addressed. The aim of this study was to investigate if CACNA1C DNA methylation is altered in BD. First, the methylation status of five CpG islands (CGIs) across CACNA1C in blood from BD subjects (n=40) and healthy controls (n=38) was determined. Four islands were almost completely methylated or completely unmethylated, while one island (CGI 3) in intron 3 displayed intermediate methylation levels. In the main analysis, the methylation status of CGI 3 was analyzed in a larger sample of BD subjects (n=582) and control individuals (n=319). Out of six CpG sites that were investigated, five sites showed significant hypermethylation in cases (lowest P=1.16 × 10(-7) for CpG35). Nearby SNPs were found to influence the methylation level, and we identified rs2238056 in intron 3 as the strongest methylation quantitative trait locus (P=2.6 × 10(-7)) for CpG35. In addition, we found an increased methylation in females, and no difference between bipolar I and II. In conclusion, we find that CACNA1C methylation is associated with BD and suggest that the regulatory effect of the non-coding risk variants involves a shift in DNA methylation

Long-term halocarbon observations from a coastal and an inland site in Sabah, Malaysian Borneo

Abstract. Short-lived halocarbons are believed to have important sources in the tropics, where rapid vertical transport could provide a significant source to the stratosphere. In this study, quasi-continuous measurements of short-lived halocarbons are reported for two tropical sites in Sabah (Malaysian Borneo), one coastal and one inland (rainforest). We present the observations for C2Cl4, CHBr3, CH2Br2* (actually ~80% CH2Br2 and ~20% CHBrCl2) and CH3I from November 2008 to January 2010 made using our μDirac gas chromatographs with electron capture detection (GC-ECD). We focus on the first 15 months of observations, showing over one annual cycle for each compound and therefore adding significantly to the few limited-duration observational studies that have been conducted thus far in southeast Asia. The main feature in the C2Cl4 behaviour at both sites is its annual cycle, with the winter months being influenced by northerly flow with higher concentrations, typical of the Northern Hemisphere, and with the summer months influenced by southerly flow and lower concentrations representative of the Southern Hemisphere. No such clear annual cycle is seen for CHBr3, CH2Br2* or CH3I. The baseline values for CHBr3 and CH2Br2* are similar at the coastal (overall median: CHBr3 1.7 ppt, CH2Br2* 1.4 ppt) and inland sites (CHBr3 1.6 ppt, CH2Br2* 1.1 ppt), but periods with elevated values are seen at the coast (overall 95th percentile: CHBr3 4.4 ppt, CH2Br2ast 1.9 ppt), presumably resulting from the stronger influence of coastal emissions. Overall median bromine values from [CHBr3 × 3] + [CH2Br2* × 2] are 8.0 ppt at the coast and 6.8 ppt inland. The median values reported here are largely consistent with other limited tropical data and imply that southeast Asia generally is not, as has been suggested, a hot spot for emissions of these compounds. These baseline values are consistent with the most recent emissions found for southeast Asia using the p-TOMCAT (Toulouse Off-line Model of Chemistry And Transport) model. CH3I, which is only observed at the coastal site, is the shortest-lived compound measured in this study, and the observed atmospheric variations reflect this, with high variability throughout the study period. This work was supported by a NERC consortium grant to the OP3 team, by NCAS, by the European Commission through the SCOUT-O3 project (505390-GOCE-CF2004) and by NERC western Pacific grant number NE/F020341/1 and NERC CAST grant number NE/J006246/1. L. M. O’Brien and M. J. Ashfold thank NERC for research studentships. A. D. Robinson acknowledges NERC for their support through small grant project NE/D008085/1. N. R. P. Harris is supported by a NERC Advanced Research Fellowship. We thank the Sabah Foundation, Danum Valley Field Centre and the Royal Society (Glen Reynolds) for field site support. The research leading to these results has received funding from the European Union’s Seventh Framework Programme FP7/2007–2013 under grant agreement no. 226224 – SHIVA. We thank David Oram and Stephen Humphrey at UEA for their assistance in checking the calibration of our Aculife cylinder in May 2009. This is paper number 626 of the Royal Society’s South East Asian Rainforest Research Programme.This is the final published version. It first appeared at http://www.atmos-chem-phys.net/14/8369/2014/acp-14-8369-2014.html