Evaluasi Penggunaan Antibiotik Pada Balita Dengan Diare Akut Di Instalasi Rawat Inap Rsud Dr. Moewardi Periode September-Desember 2015

Diarrhea is one of the most disease with high morbidity and mortality of children under five years in the Worldwide with 3 million death annually. The cause of acute diarrhea is various, it can be caused by viruses, bacterias and pathogens. Antibiotics can used to treatment acute diarrhea but not all of diarrhea should be given with antibiotics. Antibiotics are only useful for patient with blood diarrhea (dysentery), cholera and other infectious diseases. The purpose of this study were to describe and evaluate the use of antibiotics in infant patients with acute diarrhea in Dr.Moewardi Hospital period September until December 2015. This study was a non-experimental study (observational),the data were obtained rFetrospectively from patient’s medical records. Evaluation of the use of antibiotics was seen from right indication, right drug, right patient, right dose and frequency then the right of duration based on Pelayanan Kesehatan Anak di Rumah Sakit 2009 and empirical treatment of acute infectious diarrhea 2006 standart treatment. The results of this research on acute diarrhea with diagnosis dysentery and acute diarrhea at Dr. Moewardi hospital antibiotic that being used is ampicillin (31,43%), amoxicillin (20%), metronidazole (17,14%), cefotaxime (11,43%), Kotrimoksazol (5,71%) and Cefixime (2,86%). The results of evaluation antibiotics is right indication (85,71%), right patient (87,71%), right drug (52,28%), the right dose and frequency (34,28%), right duration (34,28%), and rationality (34,28% )

Hasil in Silico Senyawa Z12501572, Z00321025, SCB5631028 Dan SCB13970547 Dibandingkan Turunan Zerumbon Terhadap Human Liver Glycogen Phosphorylase (1l5Q) Sebagai Antidiabetes

Human Liver Glycogen Phosphorylase (HLGP) can catalyze glycogen and control the release of glucose-1-phosphate of glycogen from the liver. This enzyme has a central role in output rule of liver glucose as it can be used as an antidiabetic drug targets. Docking studies were carried out on PC with Intel Pentium, 1 GB RAM, in environment of Windows 7. Ligands used are drug compounds (Z12501572, Z00321025, SCB5631028 and SCB13970547), the active dataset comparator wasglycogenphosphorylase outer dimer site (PYGL-out) and decoys from www.dekois.com andzerumbonederivates. Protein was separated from its native ligand and all ligands including the protein were converted to pdbqt using PyRx. The interaction of protein-ligand was visualized using software of PLIP and PyMOL. Compound of ZER11 had the best binding energy were -7.11 kcal/mol (LGA and GA) and -4.08 kcal/mol (SA). The binding energy value was lower than the ligand native and one of the four drug compounds, especially compared with the binding affinity of dataset and decoys. Vice versa, for Vina method, the value of ligand binding protein for ZER11 (-9.9 kcal/mol) was better than the ligand native and all of the fourth drugcompounds. Vina result showed that ZER11 had the same residual interaction as the ligand native, which are TRP67 and LYS191