Anaemia and Iron studies among women of reproductive age group: A Cross-sectional survey of a Large Cantonment in Western Maharashtra

Background: Anaemia remains a major cause of concern among the women of reproductive age in our country. However, there is a wide variation amongst different socio-economic strata. Aim & Objectives: This study was conducted among women of reproductive age for prevalence of anaemia and its association with certain socio-clinical variables in cantonment. Methods: It was a cross-sectional study. The information regarding socio-demographic variables, anthropometric measurements and clinical parameters were taken. Hemogram and iron profile was done by collecting venous blood from the participants. Results: Data was analyzed for 722 participants. Out of these 140, mild, moderate and severe anaemia was seen in 57, 77, 06 respectively. The major factors associated with anaemia were heavy menstruation and higher parity. Amongst these 140, iron deficiency anaemia was diagnosed in 135 .Among the 28 pregnant women, eight were anaemic (28.6: 95% CI 19.1-63.9).Conclusion: The results of our study showed lower prevalence of anaemia than national level and majority of these were iron deficiency anaemia, which is amenable to prevention and treatment

A Scoping review of challenges, scope and assessment approaches of teledentistry: an Indian perspective

Context: In India, COVID-19 pandemic has limited the utilization and access to dental services owing to the risk of infections transmission. In this context, tele-dentistry could be useful but there is paucity of literature which provides guidance on the scope and challenges for using tele-dentistry in India. Aims: To identify challenges, scope and assessment approaches of tele-dentistry from an Indian perspective. Settings and Design: Scoping Review. Methods and Material: Scoping review was conducted using the Arksey and O’Malley framework. Databases were searched in July from April to August 2020. Studies concerning challenges and scope of tele-dentistry in India were included. Additionally, literature about assessment approaches used for tele-dentistry programs were also reviewed Results: A total of 64 studies were reviewed, out of which 26 articles were included in the final review. Scoping review reveled that tele-dentistry can act as a seamless tool for diagnosing, training and screening. Few studies suggested the relevance of smartphone technology for specialist consultations and proper diagnosis. Majority of studies revealed shortage of basic infrastructure as a major challenge for tele-dentistry in India. Assessment studies were mainly focused on economic perspective and cost-effectiveness of the programs. Conclusions: This review provide guidance for using tele-dentistry in India. It is also reflected that there is a need for further research about the assessment of tele-dentistry in terms of safety, clinical outcomes, and patient perception

Machining performance enhancement of EN-31 diesteel using MWCNT mixed rotary EDM

The present study investigates the influence of adding multi-wall carbon nanotube (MWCNT) into the dielectric fluid of electric discharge machining (EDM) in terms of material removal rate (MRR), surface roughness (SR) and surface topology of EN-31 die steel using Cu electrode. A customized rotary electrode set-up has been developed to compare the performance improvement of powder mixed rotary electrical discharge machining (PMREDM) as compared to powder mixed electrical discharge machining (PMEDM) and conventional EDM. The present study attempts to investigate the optimization of process parameters of MWCNT mixed rotary EDM of EN-31 die steel using response surface methodology (RSM) and genetic algorithm (GA) in terms of MRR and SR. The optimization results show that MWCNT mixed rotary EDM shows highest value of MRR (9.72 mm3/min) and lowest value of SR (Ra = 2.03 μm), which are approximately 46.17% higher and 45.43% lower than conventional EDM values respectively. Further, various combinations of optimal values of MRR and SR and their corresponding input parameters setting have been shown in pareto table created by multi-objective optimization GA technique available in MATLAB. Finally, field emission scanning electron microscope (FESEM) analysis of MWCNT mixed rotary EDM and EDM surfaces is carried out which revealsthat MWCNT mixed rotary EDM shows better surface topography as compared to EDM process

Machining performance enhancement of EN-31 diesteel using MWCNT mixed rotary EDM

309-319The present study investigates the influence of adding multi-wall carbon nanotube (MWCNT) into the dielectric fluid of  electric discharge machining (EDM) in terms of material removal rate (MRR), surface roughness (SR) and surface topology of EN-31 die steel using Cu electrode. A customized rotary electrode set-up has been developed to compare the performance improvement of powder mixed rotary electrical discharge machining (PMREDM) as compared to powder mixed electrical discharge machining (PMEDM) and conventional EDM. The present study attempts to investigate the optimization of process parameters of MWCNT mixed rotary EDM of EN-31 die steel using response surface methodology (RSM) and genetic algorithm (GA) in terms of MRR and SR. The optimization results show that MWCNT mixed rotary EDM shows highest value of MRR (9.72 mm3/min) and lowest value of SR (Ra = 2.03 µm), which are approximately 46.17% higher and 45.43% lower than conventional EDM values respectively. Further, various combinations of optimal values of MRR and SR and their corresponding input parameters setting have been shown in pareto table created by multi-objective optimization GA technique available in MATLAB. Finally, field emission scanning electron microscope (FESEM) analysis of MWCNT mixed rotary EDM and EDM surfaces is carried out which revealsthat MWCNT mixed rotary EDM shows better surface topography as compared to EDM process

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Strengths, weaknesses, opportunities, and threats analysis of the national program for health care of the elderly

Background: The National Program for the HealthCare of the Elderly (NPHCE) was adopted by the Ministry of Health and Family Welfare in 2010 to provide promotional, preventive, curative, and rehabilitative health-care services for the fast-growing older population in India. As literature about the assessment of NPHCE is lacking, the present study was conducted to perform a strengths, weaknesses, opportunities, and threats (SWOT) analysis of the program. Methods: The SWOT of the NPHCE program is analyzed using available literature and relevant documents. Results: Although this program embraces strategies to provide specialized training and services at primary health center, community health center, and district levels, including dedicated bedded wards, equipment, consumables, and pharmaceuticals but home-based care for the elderly, and the role of caregivers is overlooked in this program. NPHCE program can utilize the framework and take support of various ongoing healthy aging initiatives of international agencies to augment the health-care strategies for the elderly in India. Integrating schemes developed by the government for the upliftment of the elderly and the inclusion of traditional medicine systems in the program can serve as an opportunity for meeting unmet needs and improving the quality of life and well-being of the elderly. However, the growing elderly population, rise in nuclear families, and dual disease burden are significant threats to the program's implementation. Conclusion: This program can be more effective in providing comprehensive health care to the elderly if more emphasis is given to community participation, home-based care, and integrating digital health technologies and other existing welfare schemes