Histological characteristics of early-stage oral tongue cancer in young versus older patients : A multicenter matched-pair analysis

Little is known about the histopathological characteristics that may differentiate early oral tongue cancer (OTSCC) between young and older patients. From a total of 311 cases diagnosed with clinically early-stage OTSCC at 6 institutions, only 42 patients were young patients were aged 60 years old were matched for center of management, clinical stage and gender. We compared epithelial and stromal histopathologic parameters between the two groups. Most of the parameters were similar between the two groups, although the young patients appeared to have marginally higher intensity of tumor budding, histologic risk score, infiltrative pattern of invasion and tumor-stroma ratio. However, none of the factors showed significant difference when comparing the two groups. The histological parameters reflect mechanisms of invasive growth and tissue response to invasive growth, but not the etiological difference in OTSCC between young and older patients. Further investigations are necessary to compare the genetic background of early OTSCC in the two groups.Peer reviewe

Medical theses as part of the scientific training in basic medical and dental education: experiences from Finland

<p>Abstract</p> <p>Background</p> <p>Teaching the principles of scientific research in a comprehensive way is important at medical and dental schools. In many countries medical and dental training is not complete until the candidate has presented a diploma thesis. The objective of this study was to evaluate the nature, quality, publication pattern and visibility of Finnish medical diploma theses.</p> <p>Methods</p> <p>A total of 256 diploma theses presented at the University of Oulu from 2001 to 2003 were analysed. Using a standardised questionnaire, we extracted several characteristics from each thesis. We used the name of the student to assess whether the thesis resulted in a scientific publication indexed in medical article databases. The number of citations received by each published thesis was also recorded.</p> <p>Results</p> <p>A high proportion of the theses (69.5%) were essentially statistical in character, often combined with an extensive literature review or the development of a laboratory method. Most of them were supervised by clinical departments (55.9%). Only 61 theses (23.8%) had been published in indexed scientific journals. Theses in the fields of biomedicine and diagnostics were published in more widely cited journals. The median number of citations received per year was 2.7 and the range from 0 to 14.7.</p> <p>Conclusion</p> <p>The theses were seldom written according to the principles of scientific communication and the proportion of actually published was small. The visibility of these theses and their dissemination to the scientific community should be improved.</p

Space Applications of the Geant4 Simulation Toolkit

The space radiation environment is highly variable and dynamic. With the increasing number and complexity of space missions, the detailed analysis of the effects of that environment often requires the use of advanced Monte Carlo radiation transport tools. In this presentation, various space-oriented developments and applications based on the Geant4 particle transport toolkit are described

BRCA1 mislocalization leads to aberrant DNA damage response in heterozygous ABRAXAS1 mutation carrier cells

Peer reviewe

The relationship between quality of research and citation frequency

BACKGROUND: Citation counts are often regarded as a measure of the utilization and contribution of published articles. The objective of this study is to assess whether statistical reporting and statistical errors in the analysis of the primary outcome are associated with the number of citations received. METHODS: We evaluated all original research articles published in 1996 in four psychiatric journals. The statistical and reporting quality of each paper was assessed and the number of citations received up to 2005 was obtained from the Web of Science database. We then examined whether the number of citations was associated with the quality of the statistical analysis and reporting. RESULTS: A total of 448 research papers were included in the citation analysis. Unclear or inadequate reporting of the research question and primary outcome were not statistically significantly associated with the citation counts. After adjusting for journal, extended description of statistical procedures had a positive effect on the number of citations received. Inappropriate statistical analysis did not affect the number of citations received. Adequate reporting of the primary research question, statistical methods and primary findings were all associated with the journal visibility and prestige. CONCLUSION: In this cohort of published research, measures of reporting quality and appropriate statistical analysis were not associated with the number of citations. The journal in which a study is published appears to be as important as the statistical reporting quality in ensuring dissemination of published medical science

Applications of medical informatics and data analysis methods

The science of statistics contributes to the development and application of tools for the design, analysis, and interpretation of empirical medical studies [...

Ten points for high-quality statistical reporting and data presentation

Abstract Background: Data analysis methods have become an essential part of empirical research papers, especially in health sciences and medical research. It has previously been reported that a noteworthy percentage of articles have flaws in their statistical reporting. Reporting problems have been a long-term issue, and despite continued efforts to improve the situation, improvements have been far from satisfactory. One explanation is an inadequate assessment of statistical reporting during peer review. This communication proposes a short instrument to assess the quality of data analysis reporting in manuscripts and published papers. Method: A checklist-type instrument was developed by selecting and refining items from previous reports about the quality of statistical reporting in medical journals and from published guidelines for reporting and data presentation. Items were pretested and modified during pilot studies. A total of 160 original medical research articles that were published in 4 journals were evaluated to test the instrument. Interrater and intrarater agreements were examined by comparing quality scores assigned to 40 articles published in a psychiatric journal. Results: The data analysis reporting test consists of nine questions that assess the quality of health research from a reader’s perspective. The composed scale has a total score ranging from 0 to 10 and discriminated between journals and study designs. A high score suggested that an article had a good presentation of findings in tables and figures and that the description of analysis methods was helpful to readers. Interrater and intrarater agreements were high. Conclusion: An applicable checklist for quickly testing the statistical reporting quality of manuscripts and published research papers was developed. This instrument aims to improve the quality of empirical research in scientific fields where statistical methods play an important role

Use of data analysis methods in dental publications:is there evidence of a methodological change?

Abstract Objectives: To evaluate how data analysis methods in dental studies have changed in recent years. Methods: A total of 400 articles published in 2010 and 2017 in five dental journals, Journal of Dental Research, Caries Research, Community Dentistry and Oral Epidemiology, Journal of Dentistry, and Acta Odontologica Scandinavica, were analyzed. The study characteristics and the reporting of data analysis techniques were systematically identified. Results: The statistical intensity of the dental journals did not change from 2010 to 2017. Dental researchers did not adopt the data mining, machine learning, or Bayesian approaches advocated in the computer-oriented methodological literature. The determination of statistical significance was the most generally used method for conducting research in both 2010 and 2017. Observational study designs were more common in 2017. Insufficient and incomplete descriptions of statistical methods were still a serious problem. Conclusion: The stabilization of statistical intensity in the literature suggests that papers applying highly computationally complex data analysis methods have not meaningfully contributed to dental research or clinical care. Greater rigor is required in reporting the methods in dental research articles, given the current pervasiveness of failure to describe the basic techniques used

The quality of statistical reporting and data presentation in predatory dental journals was lower than in non-predatory journals

Abstract Proper peer review and quality of published articles are often regarded as signs of reliable scientific journals. The aim of this study was to compare whether the quality of statistical reporting and data presentation differs among articles published in ‘predatory dental journals’ and in other dental journals. We evaluated 50 articles published in ‘predatory open access (OA) journals’ and 100 clinical trials published in legitimate dental journals between 2019 and 2020. The quality of statistical reporting and data presentation of each paper was assessed on a scale from 0 (poor) to 10 (high). The mean (SD) quality score of the statistical reporting and data presentation was 2.5 (1.4) for the predatory OA journals, 4.8 (1.8) for the legitimate OA journals, and 5.6 (1.8) for the more visible dental journals. The mean values differed significantly (p &lt; 0.001). The quality of statistical reporting of clinical studies published in predatory journals was found to be lower than in open access and highly cited journals. This difference in quality is a wake-up call to consume study results critically. Poor statistical reporting indicates wider general lower quality in publications where the authors and journals are less likely to be critiqued by peer review

Validity of self-reported number of teeth in middle-aged Finnish adults:the Northern Finland Birth Cohort Study 1966

Abstract Background: We examined the validity of self-reported number of teeth in middle-aged adults by using representative cohort data to compare corresponding self-reported and clinical values. Methods: This validity study is part of the representative 46-year-old follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966) Study. Mailed questionnaires (n= 5950) requested information on self-reported number of teeth and background variables (education, tooth brushing and smoking), while clinical oral health examinations (n= 1891) assessed the number of teeth (the ‘gold standard’). The main analyses compared the self-reported and clinical values for the number of teeth in 1669 participants. Scatterplot and Bland-Altman plot served for visual analyses, and alternative correlation coefficients (Pearson, Spearman, intraclass) for numerical comparisons separately for men and women, with stratification according to background variables. Results: The clinical assessment revealed that the mean value for the number of teeth was 27.46 (SD = 2.38), while the corresponding value based on self-reported information was 27.48 (SD = 2.78). According to the Bland-Altman plot, the mean difference between the clinical and self-reported values was − 0.02 (95% limits of agreement, LoA: − 3.37 to 3.32). The observed ranges of intraclass correlation coefficients (ICC) among men and women were 0.72 to 0.95 and 0.72 to 0.85, respectively, depending on the background variables. Conclusions: Self-reported number of teeth in middle-aged Finnish adults agreed closely with the corresponding clinical measure