Application of NASTRAN to a fluid solids unit in the petroleum industry

The application of NASTRAN to the design of a fluid solids unit plenum/cyclone/dipleg assembly is described. The major loads considered are thermal, pressure, and gravity. Such applications are of interest in the petroleum industry since the equipment described is historically critical

A visible hand: the Fed's involvement in the check payments system

It is common knowledge that the Federal Reserve System was originally set up to provide the nation with a stable currency and a sound banking system. Less well known, however, is why the Fed was given an operating role in the nation's payments system. In this article, James N. Duprey and Clarence W. Nelson describe the problems of the check payments system before the Fed was created, suggest reasons why the private sector was unable to resolve them, and indicate how the framers of the Federal Reserve Act intended to have the Fed resolve them. Duprey and Nelson argue that while a unified national check-clearing system clearly would have been more efficient than the fragmented system that then existed, both private and Fed initiatives to reform the payments system met strong resistance from the banking community -- especially smaller nonpar banks. These banks were reluctant to give up their profitable practice of nonpar payment (paying less than the written amount of checks drawn on their accounts). Duprey and Nelson conclude that, despite the banking community's resistance, the Fed did improve the efficiency of the check payments system.Clearinghouses (Banking) ; Check collection systems ; Federal Reserve System - History ; Banks and banking - History

Life science payloads planning study integration facility survey results

The integration facility survey effort described is structured to examine the facility resources needed to conduct life science payload (LSP) integration checkout activities at NASA-JSC. The LSP integration facility operations and functions are defined along with the LSP requirements for facility design. A description of available JSC life science facilities is presented and a comparison of accommodations versus requirements is reported

Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation.

Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor receptor1 (FGFR1) (BCR-FGFR1) fusion protein. This fusion occurs in stem cell leukemia/lymphoma, which can progress to atypical chronic myeloid leukemia, acute myeloid leukemia, or B-cell lymphoma. This work focuses on the biochemical characterization of BCR-FGFR1 and identification of novel therapeutic targets. The tyrosine kinase activity of FGFR1 is required for biological activity as shown using transformation assays, interleukin-3 independent cell proliferation, and liquid chromatography/mass spectroscopy analyses. Furthermore, BCR contributes a coiled-coil oligomerization domain, also essential for oncogenic transformation by BCR-FGFR1. The importance of salt bridge formation within the coiled-coil domain is demonstrated, as disruption of three salt bridges abrogates cellular transforming ability. Lastly, BCR-FGFR1 acts as a client of the chaperonin heat shock protein 90 (Hsp90), suggesting that BCR-FGFR1 relies on Hsp90 complex to evade proteasomal degradation. Transformed cells expressing BCR-FGFR1 are sensitive to the Hsp90 inhibitor Ganetespib, and also respond to combined treatment with Ganetespib plus the FGFR inhibitor BGJ398. Collectively, these data suggest novel therapeutic approaches for future stem cell leukemia/lymphoma treatment: inhibition of BCR oligomerization by disruption of required salt bridges; and inhibition of the chaperonin Hsp90 complex

Non-Hermitian Delocalization and Eigenfunctions

Recent literature on delocalization in non-Hermitian systems has stressed criteria based on sensitivity of eigenvalues to boundary conditions and the existence of a non-zero current. We emphasize here that delocalization also shows up clearly in eigenfunctions, provided one studies the product of left- and right-eigenfunctions, as required on physical grounds, and not simply the squared modulii of the eigenfunctions themselves. We also discuss the right- and left-eigenfunctions of the ground state in the delocalized regime and suggest that the behavior of these functions, when considered separately, may be viewed as ``intermediate'' between localized and delocalized.Comment: 8 pages, 11 figures include

Three Numerical Puzzles and the Top Quark's Chiral Weak-Moment

Versus the standard model's t --> W b decay helicity amplitudes, three numerical puzzles occur at the 0.1 % level when one considers the amplitudes in the case of an additional (f_M + f_E) coupling of relative strength 53 GeV. The puzzles are theoretical ones which involve the t --> W b decay helicity amplitudes in the two cases, the relative strength of this additional coupling, and the observed masses of these three particles. A deeper analytic realization is obtained for two of them. Equivalent realizations are given for the remaining one. An empirical consequence of these analytic realizations is that it is important to search for effects of a large chiral weak-moment of the top-quark, the effective mass-scale is about 53 GeV. A full theoretical resolution would include relating the origin of such a chiral weak-moment and the mass generation of the top-quark, the W-boson, and probably the b-quark.Comment: 18 pages, 1 postscript table (revised to better explain notation, model #1, add a little material...

Levy-Student Distributions for Halos in Accelerator Beams

We describe the transverse beam distribution in particle accelerators within the controlled, stochastic dynamical scheme of the Stochastic Mechanics (SM) which produces time reversal invariant diffusion processes. This leads to a linearized theory summarized in a Shchr\"odinger--like (\Sl) equation. The space charge effects have been introduced in a recent paper~\cite{prstab} by coupling this \Sl equation with the Maxwell equations. We analyze the space charge effects to understand how the dynamics produces the actual beam distributions, and in particular we show how the stationary, self--consistent solutions are related to the (external, and space--charge) potentials both when we suppose that the external field is harmonic (\emph{constant focusing}), and when we \emph{a priori} prescribe the shape of the stationary solution. We then proceed to discuss a few new ideas~\cite{epac04} by introducing the generalized Student distributions, namely non--Gaussian, L\'evy \emph{infinitely divisible} (but not \emph{stable}) distributions. We will discuss this idea from two different standpoints: (a) first by supposing that the stationary distribution of our (Wiener powered) SM model is a Student distribution; (b) by supposing that our model is based on a (non--Gaussian) L\'evy process whose increments are Student distributed. We show that in the case (a) the longer tails of the power decay of the Student laws, and in the case (b) the discontinuities of the L\'evy--Student process can well account for the rare escape of particles from the beam core, and hence for the formation of a halo in intense beams.Comment: revtex4, 18 pages, 12 figure

A molecular mechanism directly linking E-cadherin adhesion to initiation of epithelial cell surface polarity

Mechanisms involved in maintaining plasma membrane domains in fully polarized epithelial cells are known, but when and how directed protein sorting and trafficking occur to initiate cell surface polarity are not. We tested whether establishment of the basolateral membrane domain and E-cadherin–mediated epithelial cell–cell adhesion are mechanistically linked. We show that the basolateral membrane aquaporin (AQP)-3, but not the equivalent apical membrane AQP5, is delivered in post-Golgi structures directly to forming cell–cell contacts where it co-accumulates precisely with E-cadherin. Functional disruption of individual components of a putative lateral targeting patch (e.g., microtubules, the exocyst, and soluble N-ethylmaleimide–sensitive factor attachment protein receptors) did not inhibit cell–cell adhesion or colocalization of the other components with E-cadherin, but each blocked AQP3 delivery to forming cell–cell contacts. Thus, components of the lateral targeting patch localize independently of each other to cell–cell contacts but collectively function as a holocomplex to specify basolateral vesicle delivery to nascent cell–cell contacts and immediately initiate cell surface polarity

Interaction effects in non-Hermitian models of vortex physics

Vortex lines in superconductors in an external magnetic field slightly tilted from randomly-distributed parallel columnar defects can be modeled by a system of interacting bosons in a non-Hermitian vector potential and a random scalar potential. We develop a theory of the strongly-disordered non-Hermitian boson Hubbard model using the Hartree-Bogoliubov approximation and apply it to calculate the complex energy spectra, the vortex tilt angle and the tilt modulus of (1+1)-dimensional directed flux line systems. We construct the phase diagram associated with the flux-liquid to Bose-glass transition and find that, close to the phase boundary, the tilted flux liquid phase is characterized by a band of localized excitations, with two mobility edges in its low-energy spectrum.Comment: 19 pages, 19 figures, To appear in Phys. Rev.