Kaplan–Meier survival analysis and Cox regression analyses regarding right ventricular septal pacing: Data from Japanese pacemaker cohort

AbstractThe presented data were obtained from 982 consecutive patients receiving their first pacemaker implantation with right ventricular (RV) lead placement between January 2008 and December 2013 at two centers in Japan. Patients were divided into RV apical and septal pacing groups. Data of Kaplan–Meier survival analysis and Cox regression analysis are presented. Refer to the research article “Implications of right ventricular septal pacing for medium-term prognosis: propensity-matched analysis” (Mizukami et al., in press) [1] for further interpretation and discussion

Two submarine cavernicolous crabs, Atoportunus gustavi Ng & Takeda, 2003, and Neoliomera cerasinus Ng, 2002 (Crustacea : Decapoda : Brachyura : Portunidae and Xanthidae), from Shimojijima Island, Miyako Group, Ryukyu Islands, Japan

宮古諸島下地島の海底洞窟より, モモイロドウクツガザミ (新称) とクラヤミヒラオウギガニが採集されたので報告する. 今回得られたモモイロドウクツガザミは, 先行研究による形態と色彩の記載に多くの点で一致するが, 鉗脚長節内縁に5–6歯を備える (先行研究では6歯), 鉗部可動指の咬合に2–3 歯を備える (先行研究では2 歯), という変異が見られた. また,クラヤミオウギガニにおいては, 体サイズが先行研究の例より1.6–2.3倍大きかった.Two submarine cavernicolous crabs, Atoportunus gustavi Ng & Takeda, 2003, and Neoliomera cerasinus Ng, 2002 (Crustacea: Decapoda: Brachyura: Portunidae and Xanthidae), are reported on the basis of the specimens collected at Shimojijima Island, Miyako Group, the southern Ryukyu Islands. Although examined materials of A. gustavi agree well with the previous descriptions in their morphology and coloration in life, two minor intraspecific variations are observed: the inner margin of cheliped merus armed with 5 or 6 prominent teeth (6 teeth in the previous report); and the cutting edge of chelal dactylus with 2–3 teeth (2 teeth in the previous report). The body size of N. cerasinus on hand is much larger (1.6–2.3 times) than those of the previous records

Circadian and Light-Induced Transcription of Clock Gene Per1 Depends on Histone Acetylation and Deacetylation

Circadian clock genes are regulated through a transcriptional-translational feedback loop. Alterations of the chromatin structure by histone acetyltransferases and histone deacetylases (HDACs) are commonly implicated in the regulation of gene transcription. However, little is known about the transcriptional regulation of mammalian clock genes by chromatin modification. Here, we show that the state of acetylated histones fluctuated in parallel with the rhythm of mouse Per1 (mPer1) or mPer2 expression in fibroblast cells and liver. Mouse CRY1 (mCRY1) repressed transcription with HDACs and mSin3B, which was relieved by the HDAC inhibitor trichostatin A (TSA). In turn, TSA induced endogenous mPer1 expression as well as the acetylation of histones H3 and H4, which interacted with the mPer1 promoter region in fibroblast cells. Moreover, a light pulse stimulated rapid histone acetylation associated with the promoters of mPer1 or mPer2 in the suprachiasmatic nucleus (SCN) and the binding of phospho-CREB in the CRE of mPer1. We also showed that TSA administration into the lateral ventricle induced mPer1 and mPer2 expression in the SCN. Taken together, these data indicate that the rhythmic transcription and light induction of clock genes are regulated by histone acetylation and deacetylation

Direct interaction of NRSF with TBP: chromatin reorganization and core promoter repression for neuron-specific gene transcription

Neural restrictive silencer factor, NRSF (also known as REST) binds a neuronal cell type selective silencer element to mediate transcriptional repression of neuron-specific genes in non-neuronal cells and neuronal progenitors. Two repression domains (RD-1 and RD-2) occur in its N-terminal and C-terminal regions, respectively. RD-1 recruits mSin3 and HDAC, thereby inhibiting transcription by inducing reorganization of the chromatin structure. However, little is known about how such global repression becomes promoter-specific repression or whether the NRSF–HDAC complex can interact with transcriptional core factors at each specific promoter. Here we show evidence that NRSF interacts with core promoter factors, including TATA-binding protein (TBP). The NRSF–TBP interaction occurred between the linear segments of the N- and C-terminal-most portions of NRSF and the C-terminal half of TBP. A RD-2 mutant of NRSF lost the TBP-binding activity and was unable to repress transcription at an exogenously introduced TGTA promoter. These results indicate that the direct interaction between the NRSF C-terminal domain and TBP is essential for the C-terminal repression mechanism of NRSF. Thus, the RD-1 and RD-2 repression domains of NRSF utilize both chromatin-dependent and chromatin-independent mechanisms, which may be segregated at various stages of neural development and modulation

Karstarma boholano (Ng, 2002) (Decapoda: Brachyura: Sesarmidae) from Tarama-jima Island, Ryukyu Islands, southwestern Japan

A cavernicolous sesarmid crab, Karstarma boholano (Ng, 2002), is recorded on the basis of the specimens collected from a cave in Tarama-jima Island, Ryukyu Islands, southwestern Japan. This record represents the first discovery of K. boholano from the island and slightly extends the geographical range of this species northward.多良間島の洞窟で採集された標本に基づき, ドウクツベンケイガニKarstarma boholano (Ng, 2002) を記録した. 本種の国内おける従来の記録は, 石垣島と波照間島のみであり, 今回の報告は本種の北限を僅かばかり更新した

New record of Coenobita perlatus H. Milne Edwards, 1837 (Decapoda: Anomura: Coenobitidae) from Minna-jima Island, Miyako Island Group, the southern Ryukyu Islands, Japan

A land hermit crab, Coenobita perlatus H. Milne-Edwards, 1837 (Decapoda: Anomura: Coenobitidae), is recorded on the basis of three female specimens (including two ovigerous females) collected from Minna-jima Island, Miyako Island Group, the southern Ryukyu Islands, Japan

Size-associated morphological changes in Epigrapsus notatus (Heller, 1865) and the taxonomic status of E. villosus Ng, 2003 (Crustacea: Decapoda: Brachyura: Gecarcinidae)

Naruse, Tohru, Shih, Hsi-Te, Fujita, Yoshihisa, Mendoza, Jose Christopher E., Ng, Peter K. L. (2018): Size-associated morphological changes in Epigrapsus notatus (Heller, 1865) and the taxonomic status of E. villosus Ng, 2003 (Crustacea: Decapoda: Brachyura: Gecarcinidae). Raffles Bulletin of Zoology 66: 208-216, DOI: http://doi.org/10.5281/zenodo.535860