Land slides investigation in southern Italy (ARDUO project)

There are no author-identified significant results in this report

A precise new KLOE measurement of ∣Fπ∣2|F_\pi|^2 with ISR events and determination of ππ\pi\pi contribution to aμa_\mu for 0.592<Mππ<0.9750.592 < M_{\pi\pi} < 0.975 GeV

The KLOE experiment at the DA$\Phi$NE $\phi$-factory has performed a new precise measurement of the pion form factor using Initial State Radiation events, with photons emitted at small polar angle. Results based on an integrated luminosity of 240 pb$^{-1}$ and extraction of the $\pi\pi$ contribution to $a_\mu$ in the mass range $0.35< M^2_{\pi\pi}<0.95$ GeV$^2$ are presented. The new value of $a^{\pi\pi}_\mu$ has smaller (30%) statistical and systematic error and is consistent with the KLOE published value (confirming the current disagreement between the standard model prediction for $a_\mu$ and the measured value).Comment: 5 pages, proceedings for the CIPANP 2009 conferenc

Housing system and welfare of buffalo (Bubalus bubalis) cows

Twenty-eight buffalo cows were used to evaluate the effect of housing system on a range of behavioural and physiological variables. Fourteen cows were group-housed in a loose open-sided barn with a concrete floor and 10 m2 per head as space allowance (group IS). Fourteen others were group-housed in a similar barn but they could also benefit from an outdoor yard with 500 m2 per head as space allowance, free access to potholes for wallowing and spontaneous vegetation (group TS). Animals were subjected to six sessions of instantaneous scan sampling at 10-day intervals. Behavioural variables were expressed as proportions of subjects observed in each category of posture and activity. Phytohaemagglutinin (PHA) was used to perform a skin test based on non-specific delayed type hypersensitivity, whereas 20 mg of ovalbumin were injected subcutaneously to evaluate humoral immune response. Blood samples for evaluation of cortisol concentration were collected immediately prior to exogenous porcine ACTH injection and 1, 2 and 4 h after. The metabolic status of the animals and milk production were also monitored. The proportion of idling animals was higher in group IS than in group TS (P< 0·001). More IS buffalo cows were observed eating at the manger than TS animals (P< 0·001). A higher proportion of TS animals were observed in the sun (P< 0·001). Grazing and bathing activities were recorded only for TS animals. Our findings suggest that buffalo cows kept in intensive conditions and having no access to ample yards and potholes may extend their periods of idling with negative effects on the state of welfare. Immune responses, metabolite concentrations and milk production were not affected by treatment, whereas cortisol levels were higher in IS animals (P< 0·05). The provision of a housing system similar to natural conditions was able to improve the welfare of buffalo cows as indicated by the expression of some species-specific natural behaviours. Such conditions were also associated with lower adrenal cortex response to ACTH injection, possibly as a consequence of the higher degree of initiative allowed to TS cows

Mitochondrial management of reactive oxygen species

Mitochondria in aerobic eukaryotic cells are both the site of energy production and the formation of harmful species, such as radicals and other reactive oxygen species, known as ROS. They contain an efficient antioxidant system, including low-molecular-mass molecules and enzymes that specialize in removing various types of ROS or repairing the oxidative damage of biological molecules. Under normal conditions, ROS production is low, and mitochondria, which are their primary target, are slightly damaged in a similar way to other cellular compartments, since the ROS released by the mitochondria into the cytosol are negligible. As the mitochondrial generation of ROS increases, they can deactivate components of the respiratory chain and enzymes of the Krebs cycle, and mitochondria release a high amount of ROS that damage cellular structures. More re-cently, the feature of the mitochondrial antioxidant system, which does not specifically deal with intramitochondrial ROS, was discovered. Indeed, the mitochondrial antioxidant system detoxifies exogenous ROS species at the expense of reducing the equivalents generated in mitochondria. Thus, mitochondria are also a sink of ROS. These observations highlight the importance of the mitochon-drial antioxidant system, which should be considered in our understanding of ROS-regulated pro-cesses. These processes include cell signaling and the progression of metabolic and neurodegenera-tive disease

Brugada syndrome

A novel clinical entity characterized by ST segment elevation in right precordial leads (V1 to V3), incomplete or complete right bundle branch block, and susceptibility to ventricular tachyarrhythmia and sudden cardiac death has been described by Brugada et al. in 1992. This disease is now frequently called "Brugada syndrome" (BrS). The prevalence of BrS in the general population is unknown. The suggested prevalence ranges from 5/1,000 (Caucasians) to 14/1,000 (Japanese). Syncope, typically occurring at rest or during sleep (in individuals in their third or fourth decades of life) is a common presentation of BrS. In some cases, tachycardia does not terminate spontaneously and it may degenerate into ventricular fibrillation and lead to sudden death. Both sporadic and familial cases have been reported and pedigree analysis suggests an autosomal dominant pattern of inheritance. In approximately 20% of the cases BrS is caused by mutations in the SCN5A gene on chromosome 3p21-23, encoding the cardiac sodium channel, a protein involved in the control of myocardial excitability. Since the use of the implantable cardioverter defibrillator (ICD) is the only therapeutic option of proven efficacy for primary and secondary prophylaxis of cardiac arrest, the identification of high-risk subjects is one of the major goals in the clinical decision-making process. Quinidine may be regarded as an adjunctive therapy for patients at higher risk and may reduce the number of cases of ICD shock in patients with multiple recurrences

Role of Genetic Analyses in Cardiology

Genetic analysis can be performed to identify the molecular substrate of inherited arrhythmogenic diseases; however, the role of this information in helping the management of patients is still debated. Here, we support the view that the practical value of genetic analysis is different in the various inherited conditions and that it is strongly influenced by the amount of information available in each disease about genotype-phenotype correlations. In some diseases, clinical management of patients is profoundly affected by the type of the underlying genetic defect; therefore, in these conditions, there is a high priority to introduce genetic analysis into clinical practice. In the absence of genotype-phenotype correlations, genetic testing still can be very useful when there is a clinical advantage in establishing presymptomatic diagnosis or when screening of family members may point to reproductive counseling. Finally, there is a high priority for introducing genetic testing for those genetic diseases in which a limited number of genes allow a high yield of successfully genotyped patients. We have developed a "score" to compare the value of genetic testing in arrhythmogenic diseases and to convey our view that the clinical role of genetic analysis is different in the various inherited cardiomyopathies and channelopathies. Healthcare authorities should become responsive to the advancement of knowledge in this field and should help facilitate access to genotyping for families affected by those conditions in which genetic analysis provides useful information for clinical management

Toward a detailed view on the kinematics of intermediate luminosity early-type galaxies no dark matter candidates

In several nearby intermediate luminosity early-type galaxies, recent observations at large radii have shown a indications of a lack of dark matter, substantially at odds with the prediction from the CDM hierarchical merger models. Here we discuss a pilot observational project for the study of the internal kinematical and dynamical properties of this remarkable sample of galaxies. Using the VIMOS-IFU in its high spectral resolution mode, it would be possible to investigate the regions up to about 1.2 effective radii, taking advantage of the much larger field of view and telescope diameter. This will allow to disclose the presence of any kinematical substructures which could affect the conclusion on the mass modeling and definitely clarify the inner structure of this particular class of early-type galaxies.Comment: 4 pages, 1 figure, Euro3D Science Workshop, Cambridge, May 2003, AN, accepte

Evolution of central dark matter of early-type galaxies up to z ~ 0.8

We investigate the evolution of dark and luminous matter in the central regions of early-type galaxies (ETGs) up to z ~ 0.8. We use a spectroscopically selected sample of 154 cluster and field galaxies from the EDisCS survey, covering a wide range in redshifts (z ~ 0.4-0.8), stellar masses ($\log M_{\star}/ M_{\odot}$ ~ 10.5-11.5 dex) and velocity dispersions ($\sigma_{\star}$ ~ 100-300 \, km/s). We obtain central dark matter (DM) fractions by determining the dynamical masses from Jeans modelling of galaxy aperture velocity dispersions and the $M_{\star}$ from galaxy colours, and compare the results with local samples. We discuss how the correlations of central DM with galaxy size (i.e. the effective radius, $R_{\rm e}$), $M_{\star}$ and $\sigma_{\star}$ evolve as a function of redshift, finding clear indications that local galaxies are, on average, more DM dominated than their counterparts at larger redshift. This DM fraction evolution with $z$ can be only partially interpreted as a consequence of the size-redshift evolution. We discuss our results within galaxy formation scenarios, and conclude that the growth in size and DM content which we measure within the last 7 Gyr is incompatible with passive evolution, while it is well reproduced in the multiple minor merger scenario. We also discuss the impact of the IMF on our DM inferences and argue that this can be non-universal with the lookback time. In particular, we find the Salpeter IMF can be better accommodated by low redshift systems, while producing stellar masses at high-$z$ which are unphysically larger than the estimated dynamical masses (particularly for lower-$\sigma_{\star}$ systems).Comment: 14 pages, 6 figures, 3 tables, MNRAS in pres