Antimicrobial resistance patterns of WHO priority pathogens isolated in hospitalized patients in Japan: A tertiary center observational study.

BackgroundAfter issuing the "Global action plan on antimicrobial resistance" in 2015, the World Health Organization (WHO) established a priority pathogens list for supporting research and development of novel antimicrobials. We conducted a comprehensive analysis of the WHO priority organisms in a Japanese tertiary hospital to apprehend the local AMR epidemiology.MethodsData were obtained from electrical medical records in Osaka University Hospital between January 2010 and March 2021. The critical, high, and medium "priority pathogens list" categories of the WHO were used to compare results between the early (2010-2015) and late (2016-2021) phases.ResultsOut of 52,130 culture-positive specimens, a total of 9,872 (18.9%) contained WHO priority isolates. In comparison to early phases, late phases were likely to have higher rates of carbapenem resistance in Pseudomonas aeruginosa (15.7% vs 25.0%, PConclusionsTo implement better antimicrobial stewardship policies and practices, local priority pathogens and "high-risk" patients for in-hospital death need to be acknowledged and evaluated periodically

Questionnaire Surveys on the Use of Fluoride Dentifrice among Children and their Parents in Hiroshima City

本論文の要旨は平成6年6月の第27回広島大学歯学会総会において発表した。本研究は一部平成3年度厚生省科学研究費によった

Inhibitors of Nitric Oxide Production from Stemona javanica

In our screening program for bioactive natural products from our library of tropical plants, the extract prepared from the roots of Stemona javanica inhibited NO production in mouse macrophage-like cell line J774.1 stimulated by lipopolysaccharide (LPS). Bioassay-guided fractionation of the extract from S. javanica led to the isolation of two active compounds, stemofoline (1) and stemanthrene C (2). The inhibition mechanism of 1 was proposed to suppress iNOS expression in J774.1 cells stimulated by LPS, whereas that of 2 was due to potent radical scavenging activity resulting in NO inhibitory activity

Relationship between WHO “critical priority” resistance and in-hospital mortality in various clinical profiles.

Relationship between WHO “critical priority” resistance and in-hospital mortality in various clinical profiles.</p

The percentage of antimicrobial resistance (AMR) in World Health Organization Priority Pathogen List (WHO PPL) isolates from the Osaka University Hospital between January 1, 2010, and March 31, 2021.

The percentage of antimicrobial resistance (AMR) in World Health Organization Priority Pathogen List (WHO PPL) isolates from the Osaka University Hospital between January 1, 2010, and March 31, 2021.</p

In-hospital mortality in patients with antimicrobial resistance (AMR) based on World Health Organization priority pathogen list (WHO PPL).

In-hospital mortality in patients with antimicrobial resistance (AMR) based on World Health Organization priority pathogen list (WHO PPL).</p

Percentage of resistance in World Health Organization priority pathogen list (WHO PPL) organisms to specific antimicrobials, collected from the Osaka University Hospital between January 1, 2010, and March 31, 2021.

Percentage of resistance in World Health Organization priority pathogen list (WHO PPL) organisms to specific antimicrobials, collected from the Osaka University Hospital between January 1, 2010, and March 31, 2021.</p

World Health Organization priority pathogen list (WHO PPL) isolates collected from the Osaka University Hospital between January 1, 2010, and March 31, 2021.

World Health Organization priority pathogen list (WHO PPL) isolates collected from the Osaka University Hospital between January 1, 2010, and March 31, 2021.</p