2,038 research outputs found
E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I
p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified. Further, the p62-mediated protein aggregation's effect on autophagy is unclear. We systemically analyzed the interactions of p62 with all known Atg proteins involved in LC3 lipidation. We find that p62 does not interact with LC3 at the stages when it is being processed by Atg4B or when it is complexed or conjugated with Atg3. p62 does interact with LC3-I and LC3-I:Atg7 complex and is preferentially recruited by LC3-II species under autophagic stimulation. Given that Atg4B, Atg3 and LC3-Atg3 are indispensable for LC3-II conversion, our study reveals a protective mechanism for Atg4B, Atg3 and LC3-Atg3 conjugate from being inappropriately sequestered into p62 aggregates. Our findings imply that p62 could potentially impair autophagy by negatively affecting LC3 lipidation and contribute to the development of protein aggregate diseases. © 2013 Gao et al
Method of extending hyperfine coherence times in Pr^3+:Y_2SiO_5
In this letter we present a method for increasing the coherence time of
praseodymium hyperfine ground state transitions in Pr^3+:Y_2SiO_5 by the
application of a specific external magnetic field. The magnitude and angle of
the external field is applied such that the Zeeman splitting of a hyperfine
transition is at a critical point in three dimensions, making the first order
Zeeman shift vanishingly small for the transition. This reduces the influence
of the magnetic interactions between the praseodymium ions and the spins in the
host lattice on the transition frequency. Using this method a phase memory time
of 82ms was observed, a value two orders of magnitude greater than previously
reported. It is shown that the residual dephasing is amenable quantum error
correction
Chiral symmetry breaking and stability of strangelets
We discuss the stability of strangelets by considering dynamical chiral
symmetry breaking and confinement. We use a
symmetric Nambu--Jona-Lasinio model for chiral symmetry breaking supplemented
by a boundary condition for confinement. It is shown that strangelets with
baryon number can stably exist. For the observables, we
obtain the masses and the charge-to-baryon number ratios of the strangelets.
These quantities are compared with the observed data of the exotic particles.Comment: 10 pages, 9 figures, submitted to Physical Review
Theory of the beta-type Organic Superconductivity under Uniaxial Compression
We study theoretically the shift of the superconducting transition
temperature (Tc) under uniaxial compression in beta-type organic
superconductors, beta-(BEDT-TTF)2I3 and beta-(BDA-TTP)2X[X=SbF6,AsF6], in order
to clarify the electron correlation, the spin frustration and the effect of
dimerization. The transfer integrals are calculated by the extended Huckel
method assuming the uniaxial strain and the superconducting state mediated by
the spin fluctuation is solved using Eliashberg's equation with the
fluctuation-exchange approximation. The calculation is carried out on both the
dimerized (one-band) and nondimerized (two-band) Hubbard models. We have found
that (i) the behavior of Tc in beta-(BEDT-TTF)2I3 with a stronger dimerization
is well reproduced by the dimer model, while that in weakly dimerized
beta-BDA-TTP salts is rather well reproduced by the two-band model, and (ii)
the competition between the spin frustration and the effect induced by the
fluctuation is important in these materials, which causes nonmonotonic shift of
Tc against uniaxial compression.Comment: 18 pages, 16 figures, 2 tabl
Spin-density-wave transition of (TMTSF)PF at high magnetic fields
The transverse magnetoresistance of the Bechgaard salt (TMTSF)PF has
been measured for various pressures, with the field up to 24 T parallel to the
lowest conductivity direction c. A quadratic behavior is observed in
the magnetic field dependence of the spin-density-wave (SDW) transition
temperature . With increasing pressure,
decreases and the coefficient of the quadratic term increases. These results
are consistent with the prediction of the mean-field theory based on the
nesting of the quasi one-dimensional Fermi surface. Using a mean field theory,
for the perfect nesting case is estimated as about 16 K. This
means that even at ambient pressure where is 12 K, the SDW
phase of (TMTSF)PF is substantially suppressed by the
two-dimensionality of the system.Comment: 11pages,6figures(EPS), accepted for publication in PR
First-Principles Study on Peierls Instability in Infinite Single-Row Al Wires
We present the relation between the atomic and spin-electronic structures of
infinite single-row atomic wires made of Al atoms during their elongation using
first-principles molecular-dynamics simulations. Our study reveals that the
Peierls transition indeed occurs in the wire with magnetic ordering: it
ruptures to form a trimerized structure with antiferromagnetic ordering and
changes from a conductor to an insulator just before forming a linear wire of
equally-spaced atoms. The formation of the trimerized wire is discussed in
terms of the behavior of the -symmetry bands of the Al wire.Comment: 10 pages, 4 figure
Relaxation of pressure anisotropy due to Alfvén-ion-cyclotron fluctuations observed in ion-cyclotron-range-of-frequency–heated mirror plasmas
Alfvén-ion-cyclotron modes are generated over a wide range of anisotropy parameter β⊥(T⊥/T∥)2 in ICRF-heated central cell plasmas of the GAMMA 10 tandem mirror. The fluctuations are observed at a small driving force in the convectively unstable region predicted theoretically in an infinite plasma. Before reaching the β limit of β⊥=3.52×(T∥/T⊥)2, above which the absolute instability is predicted, relaxation of pressure anisotropy is observed for the first time by use of an array of diamagnetic loops together with a Faraday cup and secondary-electron emission detectors
Distorted wave impulse approximation analysis for spin observables in nucleon quasi-elastic scattering and enhancement of the spin-longitudinal response
We present a formalism of distorted wave impulse approximation (DWIA) for
analyzing spin observables in nucleon inelastic and charge exchange reactions
leading to the continuum. It utilizes response functions calculated by the
continuum random phase approximation (RPA), which include the effective mass,
the spreading widths and the \Delta degrees of freedom. The Fermi motion is
treated by the optimal factorization, and the non-locality of the
nucleon-nucleon t-matrix by an averaged reaction plane approximation. By using
the formalism we calculated the spin-longitudinal and the spin-transverse cross
sections, ID_q and ID_p, of 12C, 40Ca (\vec{p},\vec{n}) at 494 and 346 MeV. The
calculation reasonably reproduced the observed ID_q, which is consistent with
the predicted enhancement of the spin-longitudinal response function R_L.
However, the observed ID_p is much larger than the calculated one, which was
consistent with neither the predicted quenching nor the spin-transverse
response function R_T obtained by the (e,e') scattering. The Landau-Migdal
parameter g'_N\Delta for the N\Delta transition interaction and the effective
mass at the nuclear center m^*(r=0) are treated as adjustable parameters. The
present analysis indicates that the smaller g'_{N\Delta}(\approx 0.3) and
m^*(0) \approx 0.7 m are preferable. We also investigate the validity of the
plane wave impulse approximation (PWIA) with the effective nucleon number
approximation for the absorption, by means of which R_L and R_T have
conventionally been extracted.Comment: RevTex 3, 29 pages, 2 tables, 8 figure
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