Monograph on Computation of RF Hazards

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Geometrical Defects in Josephson Junction Arrays

Dislocations and disclinations in a lattice of Josephson junctions will affect the dynamics of vortex excitations within the array. These defects effectively distort the space in which the excitations move and interact. The interaction energy between such defects and excitations are determined and vortex trajectories in twisted lattices are calculated. Finally, possible experiments observing these effects are presented.Comment: 26 pages including 5 figure

Thermomechanical design criteria for ceramic-coated surfaces

Some early history of ceramic applications is presented. Finite element modeling of components to determine service and fabrication loads found inelastic behavior and residual stresses to be significant to component life. Inelastic behavior mitigates peak strains but enhances residual strains. Results of furnace, Mach 0.3 burner, and engine tests are discussed and categorized into design criteria (loading, geometry, fabrication, materials, analysis, and testing). These design rules and finite element analyses are brought to bear on two test cases: turboshaft engine seals, and rocket thrust chambers

Transition times in the Landau-Zener model

This paper presents analytic formulas for various transition times in the Landau-Zener model. Considerable differences are found between the transition times in the diabatic and adiabatic bases, and between the jump time (the time for which the transition probability rises to the region of its asymptotic value) and the relaxation time (the characteristic damping time of the oscillations which appear in the transition probability after the crossing). These transition times have been calculated by using the exact values of the transition probabilities and their derivatives at the crossing point and approximations to the time evolutions of the transition probabilities in the diabatic basis, derived earlier \protect{[}N. V. Vitanov and B. M. Garraway, Phys. Rev. A {\bf 53}, 4288 (1996)\protect{]}, and similar results in the adiabatic basis, derived in the present paper.Comment: 7 pages, two-column revtex style, 5 figures, to appear in Phys. Rev. A (Feb 1999

Development of light weight magnesium alloys for low temperature applications Annual progress report, Jun. 19, 1965 - Mar. 20, 1966

Lightweight magnesium alloys for cryogenic application

Development of Light Weight Magnesium Alloys for Low Temperature Applications Annual Progress Report, 19 Jun. 1964 - 18 Jun. 1965

Lightweight, wrought magnesium alloys for high strength and ductility and low notch sensitivity applications at cryogenic temperature

SAFEGUARDS AND NONPROLIFERATION CONSIDERATIONS RELEVANT TO FUELS REFABRICATION AND DEVELOPMENT PROGRAM

Early in the Fuels Refabrication and Development (FRAD) program, it was recognized that safeguards and nonproliferation design criteria were needed to provide guidance to equipment, process, and facility designers. This need was highlighted by the recent attention given safeguards and proliferation. Because of this heightened concern, it was found that design criteria that adequately address safeguards and nonproliferation do not now exist. For this reason, a three-day workshop was convened to attempt to collect and organize existing information regarding design criteria. This document is a result of that undertaking and the subsequent efforts required to structure the information. In summary, it was found that domestic and international goals and objectives are reasonably well established. Goals and objectives for evaluating the proliferation resistance of a facility are less firmly defined. A listing of design criteria for domestic and international safeguards has not been compiled. This document presents a summary of considerations that must be incorporated into design criteria but stops short of developing a comprehensive list of design criteria. One is certainly needed and should be funded as a follow-on effort. Following the development of the design criteria, the next logical steps are the development of evaluation methodologies and acceptance criteria. These also were proposed as logical follow-on activities which would be needed before a major FRAD design activity could be initiated

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability

YesEffective suppression of JAK–STAT signalling by the inducible inhibitor “suppressor of cytokine signalling 3” (SOCS3) is essential for limiting signalling from cytokine receptors. Here we show that cavin-1, a component of caveolae, is a functionally significant SOCS3- interacting protein. Biochemical and confocal imaging demonstrate that SOCS3 localisation to the plasma membrane requires cavin-1. SOCS3 is also critical for cavin-1 stabilisation, such that deletion of SOCS3 reduces the expression of cavin-1 and caveolin-1 proteins, thereby reducing caveola abundance in endothelial cells. Moreover, the interaction of cavin-1 and SOCS3 is essential for SOCS3 function, as loss of cavin-1 enhances cytokine-stimulated STAT3 phosphorylation and abolishes SOCS3-dependent inhibition of IL-6 signalling by cyclic AMP. Together, these findings reveal a new functionally important mechanism linking SOCS3-mediated inhibition of cytokine signalling to localisation at the plasma membrane via interaction with and stabilisation of cavin-1.This work was supported by project grants to T.M.P. from the Chief Scientist Office (ETM/226), British Heart Foundation (PG12/1/ 29276, PG 14/32/30812), and a National Health Service Greater Glasgow and Clyde Research Endowment Fund (2011REFCH08). P.F.P. was supported by the National Institutes of Health grant DK097708. J.J.L.W. was supported by a doctoral training studentship from the Biotechnology and Biological Sciences Research Council Doctoral Training Programme in Biochemistry and Molecular Biology at the University of Glasgow (BB/F016735/1). N.A. was supported by a Saudi Government PhD Scholarship. This work was also supported in part by equipment grants to T.M.P. from Diabetes UK (BDA 11/0004309) and Alzheimer’s Research UK (ARUK-EG2016A-3)

Massive skyrmions in quantum Hall ferromagnets

We apply the theory of elasticity to study the effects of skyrmion mass on lattice dynamics in quantum Hall systems. We find that massive Skyrme lattices behave like a Wigner crystal in the presence of a uniform perpendicular magnetic field. We make a comparison with the microscopic Hartree-Fock results to characterize the mass of quantum Hall skyrmions at $\nu=1$ and investigate how the low temperature phase of Skyrme lattices may be affected by the skyrmion mass.Comment: 6 pages and 2 figure

Characterisation and properties of a small cell lung cancer cell line and xenograft WX322 with marked sensitivity to alpha-interferon.

Controversy exists as to whether interferons usefully influence the growth of epithelial carcinomas. A small cell lung carcinoma (SCLC) cell line, WX322, has been derived which is greater than 1000-fold more sensitive to alpha-interferon (IFN) when grown in agar than other reported SCLC cell lines. The WX322 line has been characterised to prove its epithelial origin and its chemosensitivity compared with that of the NCI-H69 small cell line. The WX322 cell line expresses neuroendocrine and epithelial markers and possesses a morphology consistent with SCLC origin. A concentration of 5 IU ml-1 of IFN produced 50% inhibition of colony formation in agar in the WX322 line, whereas a concentration of greater than 10(5) IU ml-1 was required to produce a comparable effect with the NCI-H69 cell line. In contrast, WX322, possessed similar sensitivity to NCI-H69 cells when exposed to a range of cytotoxic agents. Analysis of the cell cycle indicated that IFN increased the percentage of cells in the G0/G1 phase for the WX322 cell line but increased the percentage in S phase for the NCI-H69 line. Growth of the xenograft, from which the cell line was derived, was also inhibited by IFN at doses greater than 10(5) IU/mouse/day. The WX322 cell line whether grown in agar or as a xenograft shows an unusually high sensitivity to IFN and provides an interesting model for studying mechanisms of IFN cytotoxicity to epithelial cells