33 research outputs found

    The Benefits of Aviation and Local Airports

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    Evaluating Methods for Counting Aircraft Operations at Non-Towered Airports

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    Methods for Counting Aircraft at Non-Towered Airports | This Transportation Research Board–funded project analyzed three different methods for counting aircraft operations at airports without air traffic controllers: estimating operations per based aircraft, computing a flight plan to total operations ratio, and expanding a sample count. For taking sample counts, three different technologies were evaluated: acoustical, security cameras, and video image detection with ADS-B transponder receiver

    General Aviation Land Use Planning

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    In this session we discuss the value of land use planning sessions in determining airside and landside short-, mid-, and long-term needs of the airport. Land use plans have been used to secure funding and increase commercial landside and military airside growth. Currently a plan is being used to develop the first general aviation aerotropolis concept. Join us to learn how a land use plan can increase the marketability and revenue generation of your airport

    Runway Extension With a Vegetated mechanically Stabilized Earth Wall (VMSEW)

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    In this session we discuss the extension of the existing Runway 2-20 at the Paoli Municipal Airport, which sits on top of an approximately 70-foot embankment. Alternatives were analyzed to identify the most cost-effective solution, which was determined to be the construction of a vegetated mechanically stabilized earth wall (VMSEW). To date we have completed one phase of construction (approximately 30 feet of wall)

    Developing Innovative Strategies for Aviation Education and Participation

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    Resources to help promote interest in aviation among younger populations ranging from 10 years old to 25 years old are detailed in TRB’s Airport Cooperative Research Program (ACRP) Research Report 202. The report is designed to help educators and aviation enthusiasts understand the need for encouraging interest in aviation. It offers guidance on developing a program of activities to fit particular needs and provides activities for developing a program that can be scaled and tailored for various age groups and resource availability

    N-thioalkylcarbazoles derivatives as new antiproliferative agents: synthesis, characterisation and molecular mechanism evaluation

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    Synthetic or natural carbazole derivatives constitute an interesting class of heterocycles, which showed several pharmaceutical properties and occupied a promising place as antitumour tools in preclinical studies. They target several cellular key-points, e.g. DNA and Topoisomerases I and II. The most studied representative, i.e. Ellipticine, was introduced in the treatment of metastatic breast cancer. However, because of the onset of dramatic side effects, its use was almost dismissed. Many efforts were made in order to design and synthesise new carbazole derivatives with good activity and reduced side effects. The major goal of the present study was to synthesise a series of new N-thioalkylcarbazole derivatives with anti-proliferative effects. Two compounds, 5a and 5c, possess an interesting anti-proliferative activity against breast and uterine cancer cell lines without affecting non-tumoural cell lines viability. The most active compound (5c) induces cancer cells death triggering the intrinsic apoptotic pathway by inhibition of Topoisomerase II

    Exposure to growth hormone is associated with hepatic up-regulation of cPLA2α and COX

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    Continuously elevated levels of growth hormone (GH) during life in mice are associated with hepatomegaly due to hepatocytes hypertrophy and hyperplasia, chronic liver inflammation, elevated levels of arachidonic acid (AA) at young ages and liver tumors development at old ages. In this work, the hepatic expression of enzymes involved in AA metabolism, cPLA2α, COX1 and COX2 enzymes, was evaluated in young and old GH-transgenic mice. Mice overexpressing GH exhibited higher hepatic expression of cPLA2α, COX1 and COX2 in comparison to controls at young and old ages and in both sexes. In old mice, when tumoral and non-tumoral tissue were compared, elevated expression of COX2 was observed in tumors. In contrast, exposure to continuous lower levels of hormone for a short period affected COX1 expression only in males. Considering the role of inflammation during liver tumorigenesis, these findings support a role of alterations in AA metabolism in GH-driven liver tumorigenesis.Fil: Piazza, Verónica Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Matzkin, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Cicconi, Nadia Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Muia, Nadia Vanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Valquinta, Sofía. Universidad de Buenos Aires; ArgentinaFil: Mccallum, Gregorio J.. Universidad de Buenos Aires; ArgentinaFil: Micucci, Giannina P.. Universidad de Buenos Aires; ArgentinaFil: Freund, Thomas. Universidad de Buenos Aires; ArgentinaFil: Zotta, Elsa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Gonzalez, Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Fang, Yimin. Southern Illinois University School of Medicine; Estados UnidosFil: Bartke, Andrzej. Southern Illinois University School of Medicine; Estados UnidosFil: Sotelo, Ana Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Miquet, Johanna Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentin

    Corrigendum to: “Measurement of the tt ̄ production cross-section using eμ events with b-tagged jets in pp collisions at √s = 13 TeV with the ATLAS detector” [Phys. Lett. B 761 (2016) 136–157]

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    This paper describes a measurement of the inclusive top quark pair production cross-section (sigma(t (t) over bar)) with a data sample of 3.2fb(-1)of proton-proton collisions at a centre-of-mass energy of root s= 13TeV, collected in 2015 by the ATLAS detector at the LHC. This measurement uses events with an opposite-charge electron-muon pair in the final state. Jets containing b-quarks are tagged using an algorithm based on track impact parameters and reconstructed secondary vertices. The numbers of events with exactly one and exactly two b-tagged jets are counted and used to determine simultaneously sigma(t (t) over bar) and the efficiency to reconstruct and b-tag a jet from a top quark decay, thereby minimising the associated systematic uncertainties. The cross-section is measured to be:sigma(t (t) over bar) = 818 +/- 8 (stat) +/- 27 (syst) +/- 19 (lumi) +/- 12 (beam) pb,where the four uncertainties arise from data statistics, experimental and theoretical systematic effects, the integrated luminosity and the LHC beam energy, giving a total relative uncertainty of 4.4%. The result is consistent with theoretical QCD calculations at next-to-next-to-leading order. A fiducial measurement corresponding to the experimental acceptance of the leptons is also presented

    RPZ\u27s FAA Runway Protection Zones Impacts on Roadways

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    The FAA has recently changed its policy on how the areas beyond a runway must be purchased and cleared from obstructions. This change has had a major impact on existing and planned future roadways, from county roads to interstate highways in Indiana. This presentation will cover the new requirements and case examples of projects that impacted local and state agencies and the public, as well as what to do if your airport does have a roadway in its Runway Protection Zone

    Evaluating Methods for Counting Aircraft Operations at Non-Towered Airports

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    This report provides a thorough review of techniques and technologies for estimating aircraft operations at airports without air traffic control towers. The report documents the industryâs first comprehensive evaluation of the most common traffic estimation methods and is especially valuable to practitioners seeking to develop a statistically defensible estimate of aircraft activity for their non-towered airport. The research built on the results of ACRP Synthesis 4: Counting Aircraft Operations at Non-Towered Airports by reviewing recent literature and identifying new technologies. The research team then reached out to stakeholders to identify how operations data are used, confirm the criteria practitioners consider when selecting a counting method, and determine the most common counting methods used by the industry. Next, a testing program was conducted to evaluate the accuracy of three methods, including multiplying based aircraft by an estimated number of operations per based aircraft, applying a ratio of FAA flight plans to total operations, and expanding a sample count into an annual estimate through extrapolation. For the sampling method, the testing program also looked at the accuracy of different aircraft traffic counting technologies. The testing program involved installing counting systems at four airports for extended time periods to test their accuracy, reliability, and ease of use within the safety and operational constraints typically found at airports. The research also evaluated sampling plans and methods of expanding samples to produce estimates of annual activity. The research found that methods of estimating aircraft operations using ratios of based aircraft or instrument flight plans, while simple and inexpensive, could not be supported by the test results. Basing operations estimates on actual samples of activity produces results that are significantly more accurate and defensible, with the most accurate sampling approach based on four 2-week samples. Finally, the research found that the selection of a counting technology needs to consider the airfield layout and fleet mix, among other factors
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