New α-Glucosidase inhibitors from Croton bonplandianum Croton bonplandianum Baill (Euphorbiaceae)

Purpose: To isolate and evaluate α-glucosidase inhibitors from dichloromethane extract of Croton bonplandianum Baill as probable remedy for management of diabetes.Methods: Activity-guided isolation of constituents from dichloromethane extract was carried out. Fractionation of dichloromethane extract by column chromatography on silica gel and Sephadex LH 20 using different mobile phase systems led to the isolation of compounds (A-I). The structures of these isolated compounds were established by ultraviolet (UV) and infrared (IR) spectroscopy. Proton nuclear magnetic resonance (1H NMR), 13C NMR and mass spectrophotometry, electron impact mass spectroscopy (EIMS) and high resolution mass spectroscopy (HRMS) were used for structural elucidation. All the isolated compounds were screened for their α-glucosidase inhibitory activity using standard in vitro α-glucosidase inhibition assay. Acarbose was used as positive control.Results: On the basis of their physical and spectral data from literature, the isolated compounds were identified as n-pentacosanyl-n-nonadeca-7′-en-9′-α-ol 1′-oate (A), n-tridecanyl n-octadec-9,12-dienoate (B), nonacosyl hexadecanoate (C), heptacosanoic acid (D), 1,3,5-trihydroxy-2-hexadecanoylamino- (6e,9e) heptacosdiene (E),cumarin (F), betulin (G), stigmasterol (H), and 3,5-dimethoxy 4-hydroxy cinnamic acid (I).Compounds F, GandI possessed significant α glucosidase inhibitory activity in a concentration-dependent manner with 50 % inhibitory concentration (IC50) values ranging from 23.0 to 26.7 μg/mL, relative to that of the positive control, acarbose (IC50, 38.2 μg/mL).Conclusion: The plant contains bioactive compounds with α-glucosidase inhibitory activity. This lendssome support for the traditional use of this herb in the management of diabetes. Compound F, GandI possessed significant α glucosidase inhibitory activity in a concentration-dependent manner and may be developed as a new α-glucosidase inhibitor.Keywords: α-Glucosidase, Inhibition, Diabetes, Acarbose, Cumarin, Betulin, 3,5 Dimethoxy 4-hydroxy cinnamic acid, Croton bonplandianu

Corporate Governance and Environmental Reporting in Pakistan

The focus of the present study is to investigate the association between environmental reporting and corporate governance traits in Pakistan. The prior studies related to the association between environmental disclosure and corporate governance characteristics show fickle findings. This study fills the gap by using cross sectional data of 100 randomly selected firms registered at Karachi Stock Exchange for the year 2015. The results of the present research showed a positive association between the level of environmental disclosure and fraction of independent directors on the board. Negative relationship was found between environmental disclosure and institutional investors. The result shows a positive association between the level of environmental reporting and board size. It confirms a positive association. The analysis revealed a lack of association between level of environmental reporting and fraction of female directors on a board. In case of control variables, positive relationship was found between firms’ profitability and level of environmental disclosure, whereas, no correlation was found between firm size and the level of environmental reporting. Moreover, the results of incremental regression indicate that ownership concentration is the most important independent variable among all the independent variables in the model

New inequalities via Caputo-Fabrizio integral operator with applications

Fractional integral inequalities have become one of the most useful and expansive tools for the development of many fields of pure and applied mathematics over the past few years. Many authors have just recently introduced various generalized inequalities that involved the fractional integral operators. The main goal of the present study is to incorporate the concept of strongly $\left(s, m\right)$-convex functions and Hermite-Hadamard inequality with Caputo-Fabrizio integral operator. Also, we consider a new identity for twice differentiable mapping in the context of Caputo-Fabrizio fractional integral operator. Then, considering this identity as an auxiliary result, new mid-point version using well known inequalities like Hölder, power-mean, Young are presented. Moreover, some graphs of obtained inequalities are given for better understanding by the reader. Finally, we discussed some applications to matrix inequalities and spacial means

Assessment of anti-diabetic activity of Cassia sophera (Caesalpiniaceae)

Purpose: To examine the ethnomedicinal claims regarding the antidiabetic uses of Cassia sophera L. (Caesalpiniaceae) using an alloxan-induced diabetes model.Methods: The methanol extracts of leaves (CSLM) and roots (CSRM) of C. sophera were evaluated for hypoglycemic and anti-diabetic activities in normal and alloxan-induced diabetic rats. Alloxan (120 mg/kg, i.p.) was administered to induce diabetes in rats. A dose regime of 50, 100 and 200 mg/kg of CSLM and CSRM was given orally to the respective groups (n = 6). Blank group consisted of normal animals maintained on saline. The diabetic untreated group served as negative control while the group that received glibenclamide (5 mg/kg) was positive control.Results: A significant (p < 0.05) lowering of fasting blood glucose level FBG in oral glucose tolerance test (OGTT) in normal rats was observed after daily  administration of the extract for 7 days. Both extracts demonstrated decreased (p < 0.05) BGL with significantly (p < 0.05) improved glucose tolerance and body weight at the end of 4th, 7th and 14th day in extract-treated diabetic rats when compared with negative control and normal untreated group, respectively. In normoglycemic rats, CSLM and CSRM showed dose-dependent decrease in BGL.Conclusion: These results suggest that both extracts possess significant blood glucose lowering activity in normal as well as in diabetic rats.Keywords: Cassia sophera, Hypoglycemic activity, Anti-diabetic activity, Alloxan, Weight los

CHILDREN QUITTING SOIL EATING HABIT AFTER HAVING A DIET CONSISTING OF MEAT AND CALCIUM

The objective of this study was to make children quit the habit of soil eating by administeringmeat, as a source of nutrients like proteins, vitamins and minerals along with oral calcium which can be given in the form of a chewable tablet. Data of 85 children of both genders was taken having a soil eating habit. On the basis of age children were divided into 3 groups, i.e. children of 2 to 6 years of age, childrenof 6 to 12 years of age and children above 12 years of age. Children were given one tablespoon of minced meat and a tablet of calcium daily for as long as the child takes to quit the soil eating This course of treatment was proven to be fairly effective. The reason forthis success was the fact that the cause behind soil eating is the body’s requirement forcertain nutrients (e.g.Anemicpeople have been reported to have such a habit, cause being iron deficiency) and soil or clay has all these nutrients, i.e. iron, calcium, zinc, proteins, vitamins etc. and so this need can also be fulfilled through a diet of meat and additional administration of calcium. Results showed that children of ages 2 to 6 years quit the soil eating habit the fastest in which males quit in 10 days while females in 12 days. Keywords: Soil eating habit, Oral Calcium, Vitamin and Protein

Correlation between Chemical Composition of Curcuma domestica

The antioxidant activity of the curcuminoids of Curcuma domestica L. and C. xanthorrhiza Roxb. and eight compounds which are prevalent constituents of their rhizome oils were investigated in an effort to correlate human low-density lipoprotein (LDL) antioxidant activity with the effect of the herbs and their components. The antioxidant activity was examined using thiobarbituric acid reactive substances (TBARSs) assay with human LDL as the oxidation substrate. The methanol extracts and rhizome oils of C. xanthorrhiza and C. domestica showed strong inhibitory activity on copper-mediated oxidation of LDL. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin, isolated from the methanol extracts of both plants, exhibited stronger activity than probucol (IC50 value 0.57 μmol/L) as reference, with IC50 values ranging from 0.15 to 0.33 μmol/L. Xanthorrhizol, the most abundant component (31.9%) of the oil of C. xanthorrhiza, showed relatively strong activity with an IC50 value of 1.93 μmol/L. The major components of C. domestica, ar-turmerone (45.8%) and zerumbone (3.5%), exhibited IC50 values of 10.18 and 24.90 μmol/L, respectively. The high levels of curcuminoids in the methanol extracts and xanthorrhizol, ar-turmerone and zerumbone in the oils, and in combination with the minor components were responsible for the high LDL antioxidant activity of the herbs

Alpha-glucosidase inhibitory and antioxidant activities of various extracts of aerial parts of Fagonia indica Burm. F.

Purpose: To investigate in vitro antioxidant and anti-diabetic potentials of Fagonia indica Burm.f. Var. indica in order to provide scientific evidence for its traditional use. Methods: Cold maceration method was employed for the preparation of extracts of aerial parts of the plant using chloroform, n-hexane, methanol and water as solvents. Total flavonoid and polyphenolic content of various extracts were determined by standard methods. The antioxidant and anti-diabetic activities of the extracts were determined using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and in vitro αglucosidase (maltase) inhibitory assays, respectively. Results: Preliminary results indicated the presence of various phytochemicals in the extracts. The chloroform extract exhibited the highest contents of total flavonoids (65.98 ± 1.63 mg QE/g) and polyphenols (26.75 ± 1.09 mg GAE/g). This extract also showed the highest free radical scavenging (64.74 ± 1.43 %) with IC50 value of 34.18 ± 5.57 µg/mL while the methanol extract exerted the highest αglucosidase (maltase) inhibitory activity (45.22 ± 0.46 %) with half-maximal concentration (IC50) of 220.4 ± 0.41 µg/mL. Conclusion: The extracts of the aerial parts of Fagonia indica possess significant anti-diabetic and antioxidant effect, thus justifying the traditional use of the plant for treatment of diabetes

Morphological characterization, phytochemical profile, and cytotoxic and insecticidal activities of diverse parts of Bryophyllum pinnatum (Lam.)

Purpose: To standardize Zakham-e-Hayat (Bryophyllum pinnatum Lam.) as well as determine its cytotoxic and insecticidal activity. Methods: Different parts of the plant (flowers, young leaves, old leaves and stem) and different solvents, viz, methanol, ethyl acetate and n-hexane were used for the extraction. Morphological characterization (macroscopic and microscopic), phytochemical screening for primary and secondary metabolites, and thin layer chromatography (TLC) using various solvent systems, namely, methanol/chloroform (MeOH/CHCl3), n-hexane/methanol/chloroform (n-hexane/MeOH/CHCl3), methanol/chloroform/water (MeOH/CHCl3/H2O), n-hexane/chloroform (n-hexane/CHCl3), n-hexane/ethyl acetate (n-hexane/EtOAc) were carried out. Fourier transform infrared spectroscopy (FTIR) was also performed. In addition, the extracts were evaluated for their cytotoxic and insecticidal activities. Results: The methanol fraction of the young leaves had 50% lethal dose (LD50) of 28.46 µg/mL while the ethyl acetate fraction of young and old leaves showed significant cytotoxicity at LD50 of 0.13 µg/mL and 142.68 µg/mL respectively. On the other hand, n-hexane fraction was inactive. The methanol fraction of the flower revealed the presence of carbohydrates, the ethyl acetate fraction showed the presence of carbohydrates and amino acids, while the n-hexane fraction showed the presence of carbohydrates as primary metabolites. Furthermore, alkaloids, flavonoid, saponins and resins were present in the methanol fraction, flavonoid and alkaloids in the ethyl acetate fraction, and alkaloids and resins in the n-hexane fraction as secondary metabolites. Conclusion: Methanol and n-hexane fractions of Bryophyllum pinnatum have some safe bioactive compounds which may exhibit potential health benefits

Thermal-aware resource allocation in earliest deadline first using fluid scheduling

Thermal issues in microprocessors have become a major design constraint because of their adverse effects on the reliability, performance and cost of the system. This article proposes an improvement in earliest deadline first, a uni-processor scheduling algorithm, without compromising its optimality in order to reduce the thermal peaks and variations. This is done by introducing a factor of fairness to earliest deadline first algorithm, which introduces idle intervals during execution and allows uniform distribution of workload over the time. The technique notably lowers the number of context switches when compare with the previous thermal-aware scheduling algorithm based on the same amount of fairness. Although, the algorithm is proposed for uni-processor environment, it is also applicable to partitioned scheduling in multi-processor environment, which primarily converts the multi-processor scheduling problem to a set of uni-processor scheduling problem and thereafter uses a uni-processor scheduling technique for scheduling. The simulation results show that the proposed approach reduces up to 5% of the temperature peaks and variations in a uni-processor environment while reduces up to 7% and 6% of the temperature spatial gradient and the average temperature in multi-processor environment, respectively

Concept mapping and conceptual change texts: a constructivist approach to address the misconceptions in nanoscale science and technology

Nanoscale Science and Technology (NST) is a rapidly evolving field with profound implications for various industries and our everyday lives. However, misconceptions among learners can hinder their ability to grasp the fundamental concepts of NST, thereby impeding their potential contributions to this advancing domain. Concept maps (CM) and conceptual change texts (CCT) are graphical and written representations of knowledge that enable learners to visualize relationships between concepts and assess the coherence of their understanding. In this pursuit, we engage with the concept of rehabilitation for misconceptions, viewing the learning process as a transformative journey akin to cognitive rehabilitation. Through this CM-CCT constructivist approach, learners are encouraged to engage in critical reflection, self-questioning, and peer discussions, which facilitate the identification of misconceptions. Moreover, CM-CCT provide a structured framework for presenting accurate information about NST, offering a clear depiction of the hierarchical and interconnected nature of nanoscale phenomena. The aim of this study was to evaluate the effectiveness of CM-CCT in correcting the misconceptions of undergraduate university students regarding nanotechnology and the taxonomy of nonmaterial. Prior to the implementation of the CM-CCT, an assessment of pre-existing knowledge of the students was performed through the structure of the observed learning outcomes (SOLO) taxonomy. A quasi-experimental research design was carried out. A total of 70 undergraduate university students, divided into two intact groups, were cross-examined for the study. Further, before and after the instructional tools, an achievement test based on nanotechnology and classification of nonmaterial was conducted, covering all six cognitive domains of the Bloom taxonomy of educational objectives. Data analysis revealed that the instructional tools based on constructivist approach had a statistically significant impact on students for elimination of their misconceptions about nanotechnology, nano science and classification of nonmaterial