Automatic conditioning of the CTF3 RF system

The RF system of CTF3 (CLIC Test Facility 3) includes ten 35 MW to 40 MW 3 GHz klystrons and one 20 MW 1.5 GHz klystron. High power RF conditioning of the waveguide network and cavities connected to each klystron can be extremely time consuming. Because of this, a fully automatic conditioning system has been developed within a CERN JINR (Dubna) collaboration. It involves relatively minor hardware additions, most of the work being in application and front-end software. The system has already been used very successfully

Citizen Science Time Domain Astronomy with Astro-COLIBRI

Astro-COLIBRI is an innovative tool designed for professional astronomers to facilitate the study of transient astronomical events. Transient events - such as supernovae, gamma-ray bursts and stellar mergers - are fleeting cataclysmic phenomena that can offer profound insights into the most violent processes in the universe. Revealing their secrets requires rapid and precise observations: Astro-COLIBRI alerts its users of new transient discoveries from observatories all over the world in real-time. The platform also provides observers the details they need to make follow-up observations. Some of the transient phenomena available through Astro-COLIBRI are accessible by amateur astronomers and citizen scientists. A subset of the features dedicated to this growing group of users are highlighted here. They include the possibility of receiving only alerts on very bright events, the possibility of defining custom observer locations, as well as the calculation of optimized observation plans for searches for optical counterparts to gravitational wave events.Comment: Proceedings Atelier Pro-AM Gemini, Journ\'ees SF2A 2023. arXiv admin note: text overlap with arXiv:2308.0704

The acceleration of superrotation in simulated hot Jupiter atmospheres

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordContext. Atmospheric superrotating flows at the equator are a nearly ubiquitous result when conducting simulations of hot Jupiters. One theory explaining how this zonally-coherent flow reaches equilibrium has already been developed in the literature. This understanding, however, relies on the existence of either an initial superrotating flow or a sheared flow, coupled with a slow evolution that permits a linear steady state to be reached. Aims. A consistent physical understanding of superrotation is needed for arbitrary drag and radiative timescales, along with the relevance of taking linear steady states into account, needs to be assessed. Methods. We obtained an analytical expression for the structure, frequency, and decay rate of propagating waves in hot Jupiter atmospheres around a state at rest in the 2D shallow-water β–plane limit. We solved this expression numerically and confirmed the robustness of our results with a 3D linear wave algorithm. We then compared it with 3D simulations of hot Jupiter atmospheres and studied the nonlinear momentum fluxes. Results. We show that under strong day-night heating, the dynamics do not transit through a linear steady state when starting from an initial atmosphere in solid body rotation. We further demonstrate that non–linear effects favor the initial spin-up of superrotation and that acceleration due to the vertical component of the eddy–momentum flux is critical to the initial development of superrotation . Conclusions. We describe the initial phases of the acceleration of superrotation, including the consideration of differing radiative and drag timescales, and we conclude that eddy-momentum-driven superrotating equatorial jets are robust, physical phenomena in simulations of hot Jupiter atmospheres.Leverhulme TrustScience and Technology Facilities Counci

Editorial: Sociality in the Marine Environment

This is the final version. Available on open access from Frontiers Media via the DOI in this recor

Beam Dynamics and First Operation of the Sub-Harmonic Bunching System in the CTF3 Injector

The CLIC Test Facility 3 (CTF3), built at CERN by an international collaboration, aims at demonstrating the feasibility of the CLIC scheme by 2010. The CTF3 drive beam generation scheme relies on the use of a fast phase switch of a sub-harmonic bunching system in order to phase-code the bunches. The amount of charge in unwanted satellite bunches is an important quantity, which must be minimized. Beam dynamic simulations have been used to study the problem, showing the limitation of the present CTF3 design and the gain of potential upgrades. In this paper the results are discussed and compared with beam measurements taken during the first operation of the system

Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes

The mammalian respiratory chain complexes I, III 2, and IV (CI, CIII 2, and CIV) are critical for cellular bioenergetics and form a stable assembly, the respirasome (CI-CIII 2-CIV), that is biochemically and structurally well documented. The role of the respirasome in bioenergetics and the regulation of metabolism is subject to intense debate and is difficult to study because the individual respiratory chain complexes coexist together with high levels of respirasomes. To critically investigate the in vivo role of the respirasome, we generated homozygous knockin mice that have normal levels of respiratory chain complexes but profoundly decreased levels of respirasomes. Surprisingly, the mutant mice are healthy, with preserved respiratory chain capacity and normal exercise performance. Our findings show that high levels of respirasomes are dispensable for maintaining bioenergetics and physiology in mice but raise questions about their alternate functions, such as those relating to the regulation of protein stability and prevention of age-associated protein aggregation

Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and N-methylscopolamine-occupied

ABSTRACT Muscarinic MT7 toxin is a highly selective and potent antagonist of the M 1 subtype of muscarinic receptor and acts by binding to an allosteric site. To identify the molecular determinants by which MT7 toxin interacts with this receptor in its free and NMS-occupied states, the effect on toxin potency of alanine substitution was evaluated in equilibrium and kinetic binding experiments as well as in functional assays. The determination of the crystallographic structure of an MT7-derivative (MT7-diiodoTyr51) allowed the selection of candidate residues that are accessible and present on both faces of the three toxin loops. The equilibrium binding data are consistent with negative cooperativity between N-methylscopolamine (NMS) and wild-type or modified MT7 and highlight the critical role of the tip of the central loop of the toxin (Arg34, Met35 Tyr36) in its interaction with the unoccupied receptor. Examination of the potency of wild-type and modified toxins to allosterically decrease the dissociation rate of [ 3 H]NMS allowed the identification of the MT7 residues involved in its interaction with the NMSoccupied receptor. In contrast to the results with the unoccupied receptor, the most important residue for this interaction was Tyr36 in loop II, assisted by Trp10 in loop I and Arg52 in loop III. The critical role of the tips of the MT7 loops was also confirmed in functional experiments. The high specificity of the MT7-M 1 receptor interaction exploits several MT7-specific residues and reveals a different mode of interaction of the toxin with the free and NMS-occupied states of the receptor. Muscarinic neurotoxins, small peptides of 64 to 66 residues derived from the venom of African mambas (Dendroaspis angusticeps and Dendroaspis polylepis), are well known for their ability to interact with different muscarinic receptor subtypes. NMR and X-ray studies of the MT2 toxin have shown that muscarinic toxins have the three-finger fold structure, characteristic of the large superfamily of toxins that act at cholinergic synapses There is a limited understanding of the specificity, selectivity, and mechanism of action of the muscarinic toxins at Article, publication date, and citation information can be found a

Cutavirus in cutaneous malignant melanoma

A novel human protoparvovirus related to human bufavirus and preliminarily named cutavirus has been discovered. We detected cutavirus in a sample of cutaneous malignant melanoma by using viral enrichment and high-throughput sequencing. The role of cutaviruses in cutaneous cancers remains to be investigated