Functional Regression

Functional data analysis (FDA) involves the analysis of data whose ideal units of observation are functions defined on some continuous domain, and the observed data consist of a sample of functions taken from some population, sampled on a discrete grid. Ramsay and Silverman's 1997 textbook sparked the development of this field, which has accelerated in the past 10 years to become one of the fastest growing areas of statistics, fueled by the growing number of applications yielding this type of data. One unique characteristic of FDA is the need to combine information both across and within functions, which Ramsay and Silverman called replication and regularization, respectively. This article will focus on functional regression, the area of FDA that has received the most attention in applications and methodological development. First will be an introduction to basis functions, key building blocks for regularization in functional regression methods, followed by an overview of functional regression methods, split into three types: [1] functional predictor regression (scalar-on-function), [2] functional response regression (function-on-scalar) and [3] function-on-function regression. For each, the role of replication and regularization will be discussed and the methodological development described in a roughly chronological manner, at times deviating from the historical timeline to group together similar methods. The primary focus is on modeling and methodology, highlighting the modeling structures that have been developed and the various regularization approaches employed. At the end is a brief discussion describing potential areas of future development in this field

Genomic and proteomic profiling for cancer diagnosis in dogs

Global gene expression, whereby tumours are classified according to similar gene expression patterns or ‘signatures’ regardless of cell morphology or tissue characteristics, is being increasingly used in both the human and veterinary fields to assist in cancer diagnosis and prognosis. Many studies on canine tumours have focussed on RNA expression using techniques such as microarrays or next generation sequencing. However, proteomic studies combining two-dimensional polyacrylamide gel electrophoresis or two-dimensional differential gel electrophoresis with mass spectrometry have also provided a wealth of data on gene expression in tumour tissues. In addition, proteomics has been instrumental in the search for tumour biomarkers in blood and other body fluids

An Open Mapping Theorem

It is proved that any surjective morphism $f: \mathbb{Z}^\kappa \to K$ onto a locally compact group $K$ is open for every cardinal $\kappa$. This answers a question posed by Karl Heinrich Hofmann and the second author

Scheme Independence to all Loops

The immense freedom in the construction of Exact Renormalization Groups means that the many non-universal details of the formalism need never be exactly specified, instead satisfying only general constraints. In the context of a manifestly gauge invariant Exact Renormalization Group for SU(N) Yang-Mills, we outline a proof that, to all orders in perturbation theory, all explicit dependence of beta function coefficients on both the seed action and details of the covariantization cancels out. Further, we speculate that, within the infinite number of renormalization schemes implicit within our approach, the perturbative beta function depends only on the universal details of the setup, to all orders.Comment: 18 pages, 8 figures; Proceedings of Renormalization Group 2005, Helsinki, Finland, 30th August - 3 September 2005. v2: Published in jphysa; minor changes / refinements; refs. adde

String-Like Lagrangians from a Generalized Geometry

This note will use Hitchin's generalized geometry and a model of axionic gravity developed by Warren Siegel in the mid-nineties to show that the construction of Lagrangians based on the inner product arising from the pairing of a vector and its dual can lead naturally to the low-energy Lagrangian of the bosonic string.Comment: Conclusions basically unchanged, but presentation streamlined significantly. Published versio

Existence and uniqueness theorems for massless fields on a class of spacetimes with closed timelike curves

We study the massless scalar field on asymptotically flat spacetimes with closed timelike curves (CTC's), in which all future-directed CTC's traverse one end of a handle (wormhole) and emerge from the other end at an earlier time. For a class of static geometries of this type, and for smooth initial data with all derivatives in $L_2$ on {\cI}^{-}, we prove existence of smooth solutions which are regular at null and spatial infinity (have finite energy and finite $L_2$-norm) and have the given initial data on \cI^-. A restricted uniqueness theorem is obtained, applying to solutions that fall off in time at any fixed spatial position. For a complementary class of spacetimes in which CTC's are confined to a compact region, we show that when solutions exist they are unique in regions exterior to the CTC's. (We believe that more stringent uniqueness theorems hold, and that the present limitations are our own.) An extension of these results to Maxwell fields and massless spinor fields is sketched. Finally, we discuss a conjecture that the Cauchy problem for free fields is well defined in the presence of CTC's whenever the problem is well-posed in the geometric-optics limit. We provide some evidence in support of this conjecture, and we present counterexamples that show that neither existence nor uniqueness is guaranteed under weaker conditions. In particular, both existence and uniqueness can fail in smooth, asymptotically flat spacetimes with a compact nonchronal region.Comment: 47 pages, Revtex, 7 figures (available upon request