“I feel like I’m going extinct”: Conversations about the Confederacy in South Central Virginia

Summer 2015 was a time of renewed attention to the persistence and prominence of the Confederate (or rebel) flag in the southern United States. As national attention to the flag increased, I was undertaking eight weeks of preliminary fieldwork in a Virginia town named for general JEB Stuart. This paper examines the conversations surrounding the flag and other Confederate symbols that took place in person and in an online group for county residents. In it, I examine how flag supporters draw on their feelings of cultural and economic marginalization to resist the flag’s removal. While racism undergirds some of the arguments, I aim to open a conversation about how the flag is symbolically linked to old-fashioned ways of life—and its removal conflated with a threat to that way of life. For scholars and activists in favor of the flag’s removal, this work questions if and how we can remove an oppressive symbol without exacerbating some rural southerners’ sense of marginalization

Connexin-43 and Traumatic Brain Injury: A potential target for therapeutic intervention

Traumatic Brain Injury (TBI) is a widespread, degenerative affliction with no current therapeutic interventions. The long-term degradation caused by TBI results from secondary injury cascades that are initiated by primary injury. An early and important step in the damage process is reactive astrogliosis in astrocytes. Astrocytes communicate through gap junctions, which are composed of two connexon hemichannels from the two communicating cells and these connexons themselves are composed of six connexin protein subunits. Connexin 43 (Cx43) is a particularly important connexin to gap junctional communication and could act either to preserve the astrocytes from oxidative stress, or to propagate the damage signals to otherwise healthy cells. The present study investigates the expression of Cx43 in different treatment types in hippocampal samples of Wistar rats in order to elucidate the relationship between Cx43 and secondary injury through Real-Time PCR (qPCR) and cell culture work. While Cx43 has a trend for increased expression in traumatized tissue that is returned to normal levels with an antioxidant treatment, these results are not statistically significant according to a single- sided ANOVA test. Further research is needed to understand the relationship between Cx43 and secondary injury

The production of phantom partials due to nonlinearities in the structural components of the piano

Phantom partials are anomalous overtones in the spectrum of the piano sound that occur at sum and difference frequencies of the natural overtones of the string. Although they are commonly assumed to be produced by forced longitudinal waves in the string, analysis of the sound of a piano produced by mechanically vibrating the soundboard while all the strings are damped indicates that phantom partials can occur in the absence of string motion. The magnitude of the effect leads to the conclusion that nonlinearity in the non-string components may be responsible for some of the power in the phantom partials

Acute exercise facilitates brain function and cognition in children who need it most: An ERP study of individual differences in inhibitory control capacity

AbstractThe present study examined the effects of moderate-intensity aerobic exercise on aspects of cognitive control in two groups of children categorized by higher- and lower-task performance. Event-related brain potentials (ERPs) were collected in 40 preadolescent children during a modified flanker task following 20min of treadmill walking and seated rest on separate occasions. Participants were bifurcated into two groups based on task performance following the resting session. Findings revealed that following exercise, higher-performers maintained accuracy and exhibited no change in P3 amplitude compared to seated rest. Lower-performers demonstrated a differential effect, such that accuracy measures improved, and P3 amplitude increased following exercise. Lastly, both groups displayed smaller N2 amplitude and shorter P3 latency following exercise, suggesting an overall facilitation in response conflict and the speed of stimulus classification. The current findings replicate prior research reporting the beneficial influence of acute aerobic exercise on cognitive performance in children. However, children with lower inhibitory control capacity may benefit the most from single bouts of exercise. These data are among the first to demonstrate the differential effect of physical activity on individuals who vary in inhibitory control, and further support the role of aerobic exercise for brain health during development

Pathologic tearfulness after limbic encephalitis: A novel disorder and its neural basis

Objective We investigated the nature and neural foundations of pathologic tearfulness in a uniquely large cohort of patients who had presented with autoimmune limbic encephalitis (aLE). Methods We recruited 38 patients (26 men, 12 women; median age 63.06 years; interquartile range [IQR] 16.06 years) in the postacute phase of aLE who completed questionnaires probing emotion regulation. All patients underwent structural/functional MRI postacutely, along with 67 age- and sex-matched healthy controls (40 men, 27 women; median age 64.70 years; IQR 19.87 years). We investigated correlations of questionnaire scores with demographic, clinical, neuropsychological, and brain imaging data across patients. We also compared patients diagnosed with pathologic tearfulness and those without, along with healthy controls, on gray matter volume, resting-state functional connectivity, and activity. Results Pathologic tearfulness was reported by 50% of the patients, while no patient reported pathologic laughing. It was not associated with depression, impulsiveness, memory impairment, executive dysfunction in the postacute phase, or amygdalar abnormalities in the acute phase. It correlated with changes in specific emotional brain networks: volume reduction in the right anterior hippocampus, left fusiform gyrus, and cerebellum, abnormal hippocampal resting-state functional connectivity with the posteromedial cortex and right middle frontal gyrus, and abnormal hemodynamic activity in the left fusiform gyrus, right inferior parietal lobule, and ventral pons. Conclusions Pathologic tearfulness is common following aLE, is not a manifestation of other neuropsychiatric features, and reflects abnormalities in networks of emotion regulation beyond the acute hippocampal focus. The condition, which may also be present in other neurologic disorders, provides novel insights into the neural basis of affective control and its dysfunction in disease

Early and efficient detection of Mycobacterium tuberculosis in sputum by microscopic observation of broth cultures.

Early, efficient and inexpensive methods for the detection of pulmonary tuberculosis are urgently needed for effective patient management as well as to interrupt transmission. These methods to detect M. tuberculosis in a timely and affordable way are not yet widely available in resource-limited settings. In a developing-country setting, we prospectively evaluated two methods for culturing and detecting M. tuberculosis in sputum. Sputum samples were cultured in liquid assay (micro broth culture) in microplate wells and growth was detected by microscopic observation, or in Löwenstein-Jensen (LJ) solid media where growth was detected by visual inspection for colonies. Sputum samples were collected from 321 tuberculosis (TB) suspects attending Bugando Medical Centre, in Mwanza, Tanzania, and were cultured in parallel. Pulmonary tuberculosis cases were diagnosed using the American Thoracic Society diagnostic standards. There were a total of 200 (62.3%) pulmonary tuberculosis cases. Liquid assay with microscopic detection detected a significantly higher proportion of cases than LJ solid culture: 89.0% (95% confidence interval [CI], 84.7% to 93.3%) versus 77.0% (95% CI, 71.2% to 82.8%) (p = 0.0007). The median turn around time to diagnose tuberculosis was significantly shorter for micro broth culture than for the LJ solid culture, 9 days (interquartile range [IQR] 7-13), versus 21 days (IQR 14-28) (p<0.0001). The cost for micro broth culture (labor inclusive) in our study was US $4.56 per sample, versus US$11.35 per sample for the LJ solid culture. The liquid assay (micro broth culture) is an early, feasible, and inexpensive method for detection of pulmonary tuberculosis in resource limited settings

Injury in starting and replacement players from five professional men’s rugby unions

Objectives: The aim of this study was to compare the incidence, severity, and burden of injury in starting and replacement players from professional men’s teams of five rugby unions. Methods: Match injuries of greater than 24 h time-loss (including data on the severity, match quarter, event, body region) and player minutes of match exposure data were collated for all starting and replacement players in the men’s English Premiership, Welsh Pro14 (both 2016/17–2018/19 seasons), and Australian, New Zealand, and South African Super Rugby (all 2016–2018 seasons) teams. Injury incidences and mean injury burden (incidence × days missed) were calculated, and rate ratios (RRs) (95% confidence intervals [CIs]) were used to compare injury incidence and burden between starting (reference group) and replacement players. Results: Overall injury incidence was not different between starters and replacements for all injuries (RR = 0.98, 95% CI 0.88–1.10), nor for concussions (RR = 0.85; 95% CI 0.66–1.11). Mean injury burden was higher for replacement players (RR = 1.31, 95% CI 1.17–1.46). Replacement injury incidence was lower than the starters in the third (RR = 0.68, 95% CI 0.51–0.92) and fourth (RR = 0.78, 95% CI 0.67–0.92) match quarters. Injury incidence was not different between starters and replacements for any match event or body region, but compared with starters, replacements’ injury burden was higher in lower limbs (RR = 1.24, 95% CI 1.05–1.46) and in the tackled player (RR = 1.30, 95% CI 1.01–1.66). Conclusion: This study demonstrated a lower injury incidence in replacement players compared with starters in the second half of matches, with a higher injury burden for replacement players due to higher mean injury severity