Impacto de la globalización y la sociedad red en el perfil del gestor deportivo

En la actualidad los constantes cambios en el mundo laboral apuntan a nuevos sistemas de trabajo basados en los atributos, capacidades y competencias de cada trabajador, más que en la organización de las tareas. Se valora a los trabajadores por su capacidad de adaptación tecnológica y organizativa

Characterization of MSB Synapses in Dissociated Hippocampal Culture with Simultaneous Pre- and Postsynaptic Live Microscopy

Multisynaptic boutons (MSBs) are presynaptic boutons in contact with multiple postsynaptic partners. Although MSB synapses have been studied with static imaging techniques such as electron microscopy (EM), the dynamics of individual MSB synapses have not been directly evaluated. It is known that the number of MSB synapses increases with synaptogenesis and plasticity but the formation, behavior, and fate of individual MSB synapses remains largely unknown. To address this, we developed a means of live imaging MSB synapses to observe them directly over time. With time lapse confocal microscopy of GFP-filled dendrites in contact with VAMP2-DsRed-labeled boutons, we recorded both MSBs and their contacting spines hourly over 15 or more hours. Our live microscopy showed that, compared to spines contacting single synaptic boutons (SSBs), MSB-contacting spines exhibit elevated dynamic behavior. These results are consistent with the idea that MSBs serve as intermediates in synaptic development and plasticity

Machine learning to predict major bleeding during anticoagulation for venous thromboembolism: possibilities and limitations

Predictive tools for major bleeding (MB) using machine learning (ML) might be advantageous over traditional methods. We used data from the Registro Informatizado de Enfermedad TromboEmbólica (RIETE) to develop ML algorithms to identify patients with venous thromboembolism (VTE) at increased risk of MB during the first 3 months of anticoagulation. A total of 55 baseline variables were used as predictors. New data prospectively collected from the RIETE were used for further validation. The RIETE and VTE-BLEED scores were used for comparisons. External validation was performed with the COMMAND-VTE database. Learning was carried out with data from 49 587 patients, of whom 873 (1.8%) had MB. The best performing ML method was XGBoost. In the prospective validation cohort the sensitivity, specificity, positive predictive value and F1 score were: 33.2%, 93%, 10%, and 15.4% respectively. F1 value for the RIETE and VTE-BLEED scores were 8.6% and 6.4% respectively. In the external validation cohort the metrics were 10.3%, 87.6%, 3.5% and 5.2% respectively. In that cohort, the F1 value for the RIETE score was 17.3% and for the VTE-BLEED score 9.75%. The performance of the XGBoost algorithm was better than that from the RIETE and VTE-BLEED scores only in the prospective validation cohort, but not in the external validation cohort

Evaluación de la calidad percibida en eventos deportivos universitarios: Universiada Nacional

El objetivo de la presente investigación fue evaluar la calidad percibida en el evento deportivo universitario llamado Universiada Nacional 2017, con sede en la Universidad Autónoma de Nuevo León, para el análisis de los datos se utilizó el software estadístico SPSS v.24. Se realizaron los análisis descriptivos y de correlación de la muestra. El instrumento utilizado fue el QUNISPORT v.mx, con una adaptación para dicho evento, formado por 5 factores: (1) Funcionalidad y confort de las áreas deportivas universitarias; (2) Interacción con el entrenador; (3) Gestión del servicio deportivo; (4) Características del programa de actividades deportivas; (5) Ambiente y comodidad de cuartos de baño/vestidores. Se aplicó a una muestra de 371 participantes durante la justa deportiva, con un rango de edad entre los 16 y los 27 años, de los cuáles 187 (50.4%) pertenecen al género masculino y 184 (49.6%) al género femenino. Entre los resultados obtenidos, el estudio presenta valores de calidad aceptables para dicho evento deportivo. Como conclusión la evaluación de los servicios deportivos universitarios son de vital importancia para realizar un adecuado seguimiento del funcionamiento y de la percepción de sus usuarios a la gestión deportiva universitaria

Effect of salinity on DNA methylation and antioxidant phenolic compounds of wild watercress (Rorippa nasturtium aquaticum)

Epigenetic changes are involved in plant responses to stress. Cytosine methylation is one of the most important epigenetic changes, regulating gene expression. In this paper, the MSAP (methylation-sensitive amplification polymorphism) method was used to find out how the watercress (Rorippa nasturtium aquaticum) genome changed in response to 0, 60, 80, and 100 mM NaCl and how that affected phenylalanine ammonium lyase (PAL) activity, phenolic content, and antioxidant capacity. The results showed an inverse correlation between methylation levels and PAL activity and the contents of total phenolics and flavonoids, indicating salt stress-induced reprogramming of the methylation pattern of watercress, which has a negative effect on the synthesis of phenolics. The results revealed a significant decrease in phenolic contents and antioxidant activity under low and moderate salinity compared to control and an increase under strong salinity compared to moderate salinity. The findings of this study contribute to our understanding of the reprogramming of DNA methylation under salinity and its effect on watercress phenolic metabolism

Mutations in EDA and EDAR Genes in a Large Mexican Hispanic Cohort with Hypohidrotic Ectodermal Dysplasia

Ectodermal dysplasias (ED) encompass nearly 200 different genetic conditions identified by the lack, or dysgenesis, of at least two ectodermal derivatives, such as hair, nails, teeth, and sweat glands. Hypohidrotic/anhidrotic ED (HED) is the most frequent form of ED and it can be inherited as an X-linked (XL)-HED (MIM 305100), autosomal recessive (AR)-HED (MIM 224900), or autosomal dominant (AD)-HED (MIM 229490) condition. HED is caused by mutations in any of the three ectodisplasin pathway genes: ectodisplasin (EDA), which encodes a ligand for the second gene, the EDA receptor (ectodysplasin A-receptor, EDAR), and EDARADD, an intracellular signaling for this pathway. HED is characterized by a triad of clinical features including absent or diminished eccrine sweat glands, missing and/or malformed teeth, and thin, sparse hair. It also includes dryness of the skin, eyes, airways, and mucous membranes, as well as other ectodermal defects and, in some cases, fever, seizures, and rarely, death. XL-HED is caused by mutations in the EDA gene, located on chromosome Xq12-q13.1, which encodes a signaling molecule of the tumor necrosis factor (TNF) superfamily. AR- and AD-HED are caused by mutations in the EDAR gene, located on chromosome 2q11.q13 or the EDARAssociated Death Domain encoding gene, EDARADD, located on chromosome 1q42-q431. Several mutations in the EDA, EDAR, and EDARADD genes have been described as causing HED in different populations. The XL-HED form is the most common and is responsible for 90% of all HED cases2-6. The three forms of HED are clinically indistinguishable. To date, a comprehensive evaluation of HED in the Mexican Hispanic population has not been undertaken. In the present study, we aimed to characterize the mutations in EDA, EDAR, and EDARADD genes present in Mexican Hispanic patients with HED. Male and female patients (35 families) from different geographical regions of Mexico with features suggestive of HED were enrolled in the study (Fig. 1). Index cases and their parents were screened for missing or malformed teeth, thin or sparse hair, and nail changes; all subjects answered questions about sweating, heat intolerance, fever, seizures, and family history of siblings deceased due to unknown feve

COMPUESTOS FENÓLICOS Y LA ACTIVIDAD BIOLÓGICA DE TRES ESPECIES DE PLANTAS SILVESTRES DEL ESTADO DE DURANGO, MÉXICO (Fouquieria splendens, Dodonaea viscosa y Physalis angulata)

Las plantas sintetizan una gran variedad de compuestos químicos llamados metabolitos secundarios, entre ellos se encuentran los compuestos fenólicos también llamados polifenoles. Gracias a su estructura química, los compuestos fenólicos cuentan con una actividad biológica variada, entre ellas la actividad antioxidante y antimicrobiana. En este trabajo de investigación se caracterizaron químicamente extractos etanólicos foliares de tres especies de plantas silvestres del Estado de Durango (Fouquieria splendens, Dodonaea viscosa y Physalis angulata) y se determinó la actividad antioxidante y antibacteriana. La caracterización química se realizó por medio de técnicas cromatográficas (HPLC-DAD y HPLC-LTQ XL) y espectrofotométricas (cuantificación de fenoles y flavonoides totales). A partir de diferentes concentraciones, el contenido fenólico total fue de 211.32 ± 1.23, 110.34 ± 11.42 y 34.82 ± 1.49 mg EAG/g ES y flavonoides totales de 12.26 ± 0.31, 26.59 ± 2.08 y 21.15 ± 0.62 mg EAA/g ES para F. splendens, D. viscosa y P. angulata respectivamente. La actividad antioxidante fue evaluada por las técnicas de DPPH*, ABTS•+ y PR, siendo F. splendens la de mayor actividad en todas las determinaciones (0.051 ± 0.00 EC50 mg/mL, 0.110 ± 0.00 EC50 mg/mL, 1.349 ± 0.15 A 700 nm). La actividad antibacteriana se evaluó por los métodos de difusión en agar por pocillo (well diffusion method) y microdilución en caldo ante bacterias patógenas de referencia (Staphylococus aureus, Salmonella typhimurium, Escherichia coli, Vibrio cholerae y Pseudomonas aeruginosa). Los extractos de F. splendens resultaron ser efectivos ante todas las bacterias probadas, D. viscosa, sólo mostro actividad ante S. aureus, V. cholerae y P. aeruginosa, P. angulata actuó únicamente frente a S. aureus

Photocatalytic activity of Fe3O4–Fe2O3 particles supported on mordenite under visible light exposure for methylene blue degradation

Abstract Dyes pollution is a serious environmental problem and heterogeneous catalysis has been proposed as a remediation method. In this study, a set of catalysts of synthetic mordenite with iron oxides was synthesized by a simple chemical co-precipitation method assisted by subsequent thermal treatment with an oxidation process. Physicochemical characterization of prepared materials was performed by a variety of techniques, including XRD, SEM, EDS, S BET , UV–Vis DR, and XPS. Photocatalytic methylene blue (MB) degradation by the synthesized catalyst was evaluated with visible light excitation. From the studied set of catalysts, the sample prepared with a thermal treatment at 100 °C in air atmosphere for 3 h was capable of degrading ~ 90% of MB after 120 min with visible light of λ = 420 nm exposition and a small portion of H2O2 added. The catalyst used three processes to degrade MB: (1) adsorption of organic residues in the mordenite matrix support for electrostatic interactions, (2) photocatalysis heterogeneous reaction with visible light and (3) Fenton reaction catalyst with a small portion to H2O2 by Fe3O4–Fe2O3 presence. The catalytic efficiency to dye degradation was improved by a simple and economical thermal treatment without changing reaction conditions like pH, temperature, dose, or other. Studied mordenite iron oxide catalysts can be retrieved and reused at least five times without noticeable degradation, taking advantage of their magnetic properties. These catalysts could be proposed an economical, simple, and non-toxic alternative for eliminating organic dye pollution using visible light or solar irradiation in wastewater remediation related to textile, food, and pharmaceutical industries