Appropriation from the works of Nelson Leimer : a theoretical practical experience in early childhood education developed in PARFOR

It is through play that children develop sociability, make friends and exercise their full potential. Therefore, the act of playing, for children, is not a matter of pure fun but also of education, of socialization, of construction of a full development. Based on these principles, we will present in this article the result of a teaching proposal involving children of early childhood education in the discipline Stage in Visual Arts in the UNOCHAPECÓ University for the PARFOR mode, with the theme 'Appropriation from the works of Nelson Leirnerinfo:eu-repo/semantics/publishedVersio

The sensory experiences in the work of Hélio Oiticica : theory and practice

The art allows different reflections.artists have the freedom to express themselves using different languages and materials. Under this assumption we present with this article entitled “The sensory experiences in the work of Hélio Oiticica: Theory and Practice”, the result of a leaning and teaching proposal involving children of elementary school in the discipline of Visual Arts in Stage of Unochapecó — SCinfo:eu-repo/semantics/publishedVersio

estudos artísticos

A revista de estudos artísticos GAMA encontra, neste terceiro número, um caminho mais definido dentro do projeto global da comunicação de artistas sobre as obras de outros artistas. A Revista GAMA percorre tradições, registos, ações e intervenções artísticas, que assinalaram diversos momentos, com diferentes graus de difusão. Visa-se resgatar, recuperar a arte: é voltar a olhar, pelo escopo particular de um artista, a intervenção de um outro artista, com algum tempo de intervalo entre ambos. Este intervalo é um tempo de sedimentação, de filtragem, ou de recuperação de valores quase esquecidos. O tempo pode fornecer um ponto de vista privilegiado que permite novas interpretações, valorizações, interligações. Permite-se a reativação, o restauro: restauro não no sentido material, mas no sentido da reapresentação do conteúdo possibilitando reforçar um “museu imaginário,” livre de fronteiras e de hierarquias estabelecidas (Malraux). Os objetos de arte anteriores podem ter originado, ou vir a originar, novas obras, na sequência imprevisível dos discursos humanos mais significativos, reagrupando-se em termos de “ação” ou de “orientação,” de “imagem” ou de “palavra,” (Warburg) permitindo “restituir ao discurso o caráter de acontecimento” (Foucault). Entre a história e a memória, o arquivo e a deriva, a viagem e a identidade, a permanência e a resistência, a Revista GAMA vem assinalando um percurso de salvaguarda, de marcação de registos, de preservação de uma riqueza, ora material ora conceptual: a arte detém-se e debruça-se sobre as suas marcas, os seus projetos, os seus registos, as suas transições. Debruçamo-nos sobre os homens.info:eu-repo/semantics/publishedVersio

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

A fotografia como recurso de memória

Este trabalho é o resultado de uma pesquisa desenvolvida no curso de Artes Visuais – Licenciatura da UNOCHAPECÓ, o qual apresenta como tema “a fotografia como recurso de memória”. O trabalho visa demonstrar a grande capacidade que a fotografia tem diante da história, principalmente para os indivíduos no que se refere às lembranças. Ela também vem nos orientando à reconstrução da nossa história, sendo como individuo ou como participante de diversos grupos sociais. A pesquisa teve como objetivo: compreender a importância da fotografia como recurso de memória, tendo como referência as fotografias da jornalista e fotógrafa Eliane Fistarol na obra “A terra é vida: movimentos políticos e sociais no Oeste de Santa Catarina nos anos 1980 e 1990”. A pesquisa foi aplicada no ensino infantil, fundamental, médio e não formal, este artigo abordará a experiência no ensino infantil e fundamental

Molecular identification and typing of Mycobacterium massiliense isolated from postsurgical infections in Brazil

AbstractObjectiveOne hundred thirty-one cases of postsurgical infections were reported in Southern Region of Brazil between August 2007 and January 2008. Thirty-nine (29.8%) cases were studied; this report describes epidemiological findings, species identification, antimicrobial susceptibility and clonal diversity of rapidly growing mycobacteria isolated in this outbreak.MethodsAll 39 isolates were analyzed by Ziehl-Nielsen stained smear, bacterial culture and submitted to rpoB partial gene sequencing for identification. The isolates were also evaluated for their susceptibility to amikacin, cefoxitin, clarithromycin, ciprofloxacin, doxycycline, tobramycin and sulfamethoxazole.ResultsThirty-six isolates out of the confirmed cases were identified as Mycobacterium massiliense and the remaining three were identified as Mycobacterium abscessus, Mycobacterium chelonae and Mycobacterium fortuitum. All M. massiliense isolates were susceptible to amikacin (MIC90=8μg/mL) and clarithromycin (MIC90=0.25μg/mL) but resistant to cefoxitin, ciprofloxacin, doxycycline, tobramycin and sulfamethoxazole. Molecular analysis by pulsed-field gel electrophoresis clustered all 36 M. massiliense isolates and showed the same pattern (BRA 100) observed in three other outbreaks previously reported in Brazil.ConclusionsThese findings suggest a common source of infection for all patients and reinforce the hypotheses of spread of M. massiliense BRA100 in Brazilian hospital surgical environment in recent years

Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-\u3baB nuclear binding and increase in PPAR\u3b3 expression.

It is now well accepted that oxysterols play important roles in the formation of atherosclerotic plaque, involving cytotoxic, pro-oxidant and proinflammatory processes. It has been recently suggested that tomato lycopene may act as a preventive agent in atherosclerosis, although the exact mechanism of such a protection is not clarified. The main aim of this study was to investigate whether lycopene is able to counteract oxysterol-induced proinflammatory cytokines cascade in human macrophages, limiting the formation of atherosclerotic plaque. Therefore, THP-1 macrophages were exposed to two different oxysterols, such as 7-keto-cholesterol (4-16 \u3bcM) and 25-hydroxycholesterol (2-4 \u3bcM), alone and in combination with lycopene (0.5-2 \u3bcM). Both oxysterols enhanced pro-inflammatory cytokine [interleukin (IL)-1\u3b2, IL-6, IL-8, tumor necrosis factor \u3b1) secretion and mRNA levels in a dose-dependent manner, although at different extent. These effects were associated with an increased reactive oxygen species (ROS) production through an enhanced expression of NAD(P)H oxidase. Moreover, a net increment of phosphorylation of extracellular regulated kinase 1/2, p-38 and Jun N-terminal kinase and of nuclear factor kB (NF-\u3baB) nuclear binding was observed. Lycopene prevented oxysterol-induced increase in pro-inflammatory cytokine secretion and expression. Such an effect was accompanied by an inhibition of oxysterol-induced ROS production, mitogen-activated protein kinase phosphorylation and NF-\u3baB activation. The inhibition of oxysterol-induced cytokine stimulation was also mimicked by the specific NF-\u3baB inhibitor pyrrolidine dithiocarbamate. Moreover, the carotenoid increased peroxisome proliferator-activated receptor \u3b3 levels in THP-1 macrophages. Taken all together, these data bring new information on the anti-atherogenic properties of lycopene, and on its mechanisms of action in atherosclerosis prevention