Recurrence and prognostic factors in patients with aggressive fibromatosis : the role of radical surgery and its limitations

Background: Surgery is still the standard treatment for aggressive fibromatosis (AF); however, local control remains a significant problem and the impact of R0 surgery on cumulative recurrence (CR) is objective of contradictory reports. Methods: This is a single-institution study of 62 consecutive patients affected by extra-abdominal and intra-abdominal AF who received macroscopically radical surgery within a time period of 15 years. Results: Definitive pathology examination confirmed an R0 situation in 49 patients and an R1 in 13 patients. Five-year CR for patients who underwent R0 vs R1 surgery was 7.1% vs 46.4% (P = 0.04) and for limbs vs other localizations 33.3% vs 9.9% (P = 0.02) respectively. In 17 patients who had intraoperative frozen section (IFS) margin evaluation R0 surgery was more common (17 of 17 vs 32 of 45, P = 0.01) and CR lower (five-year CR 0% vs 19.1%, respectively, P = 0.04). However, in multivariate analysis only limb localization showed a negative impact on CR (HR: 1.708, 95% CI 1.03 to 2.84, P = 0.04). Conclusions: IFS evaluation could help the surgeon to achieve R0 surgery in AF. Non-surgical treatment, including watchful follow-up, could be indicated for patients with limb AF localization, because of their high risk of recurrence even after R0 surgery

Performance study of a 3 x 1 x 1 m(3) dual phase liquid Argon Time Projection Chamber exposed to cosmic rays

This work would not have been possible without the support of the Swiss National Science Foundation, Switzerland; CEA and CNRS/IN2P3, France; KEK and the JSPS program, Japan; Ministerio de Ciencia e Innovacion in Spain under grants FPA2016-77347-C2, SEV-2016-0588 and MdM-2015-0509, Comunidad de Madrid, the CERCA program of the Generalitat de Catalunya and the fellowship (LCF/BQ/DI18/11660043) from "La Caixa" Foundation (ID 100010434); the Programme PNCDI III, CERN-RO, under Contract 2/2020, Romania; the U.S. Department of Energy under Grant No. DE-SC0011686. This project has received funding from the European Union's Horizon 2020 Research and Innovation program under Grant Agreement no. 654168. The authors are also grateful to the French government operated by the National Research Agency (ANR) for the LABEX Enigmass, LABEX Lyon Institute of Origins (ANR-10-LABX-0066) of the Universite de Lyon for its financial support within the program "Investissements d'Avenir" (ANR-11-IDEX-0007).We report the results of the analyses of the cosmic ray data collected with a 4 tonne (3x1x1 m(3)) active mass (volume) Liquid Argon Time-Projection Chamber (TPC) operated in a dual-phase mode. We present a detailed study of the TPC's response, its main detector parameters and performance. The results are important for the understanding and further developments of the dual-phase technology, thanks to the verification of key aspects, such as the extraction of electrons from liquid to gas and their amplification through the entire one square metre readout plain, gain stability, purity and charge sharing between readout views.Swiss National Science Foundation (SNSF)French Atomic Energy CommissionCentre National de la Recherche Scientifique (CNRS)High Energy Accelerator Research Organization (KEK)Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceSpanish Government FPA2016-77347-C2 SEV-2016-0588MdM-2015-0509Comunidad de MadridCERCA program of the Generalitat de CatalunyaLa Caixa Foundation LCF/BQ/DI18/11660043 100010434Programme PNCDI III, RomaniaCERN-RO, Romania 2/2020United States Department of Energy (DOE) SC0011686European Commission 654168Universite de Lyon ANR-10-LABX-0066 ANR-11-IDEX-000

Cisticercosi cerebrale: quale management?

Riportiamo una casistica di nove casi di cisticercosi cerebrale, in 5 maschi e 4 femmine, di età tra 15 e 65 anni (media 46 a.), incontrati negli ultimi 25 anni. La localizzazione dei cisticerchi era: endoventricolare temporale dx (1 caso), cisterna magna e quarto ventricolo (1 caso), parasellare (3 casi), temporoparietale, endoventricolare, cisterne di Silvio ed ambiens (i caso), frontale sottocorticale sinistra (1 caso), diffusa sotto forma di minuscole calcificazioni (1 caso), circonvoluzione frontale ascendente motoria dx (I caso). I primi cinque casi, tutti appartenenti alla forma racemosa e tutti operati, risalgono al primo decennio in epoca antecedente la comparsa dell’esame Tomodensitometrico. Di questi, solo in un caso l’evoluzione è stata sfavorevole per una estesa disseminazione dei cisticerchi lungo gli spazi subaracnoidei della base. Degli ultimi 4 casi, che hanno potuto beneficiare della moderna diagnostica di rappresentazione per immagini, uno non è stato operato perché presentava solo diffuse minuscole calcificazioni delle cisti, ed uno ha potuto invece beneficiare dell’impiego della metodica stereotassica che, con una minima invasività chirurgica, ha consentito la diagnosi e la terapia. Dei due casi operati solo uno, che presentava una notevole estensione nella localizzazione delle cisti, ha avuto una evoluzione sfavorevole. Le moderne metodiche diagnostiche, consentono di porre, sempre più facilmente, una affidabile diagnosi di natura, di sede e di estensione delle lesioni da cisticerchi, permettendo così di programmare meglio il tipo e le modalità del trattamento chirurgico e/o medico