1,489 research outputs found
Nanosized patterns as reference structures for macroscopic transport properties and vortex phases in YBCO films
This paper studies the striking correlation between nanosized structural
patterns in YBCO films and macroscopic transport current. A nanosized network
of parallel Josephson junctions laced by insulating dislocations is almost
mimicking the grain boundary structural network. It contributes to the
macroscopic properties and accounts for the strong intergranular pinning across
the film in the intermediate temperature range. The correlation between the two
networks enables to find out an outstanding scaling law in the (Jc,B) plane and
to determine meaningful parameters concerning the matching between the vortex
lattice and the intergranular defect lattice. Two asymptotic behaviors of the
pinning force below the flux flow regime are checked: the corresponding vortex
phases are clearly individuated.Comment: 4 pages, 4 figure
Hydrodynamic lift of vesicles under shear flow in microgravity
The dynamics of a vesicle suspension in a shear flow between parallel plates
has been investigated under microgravity conditions, where vesicles are only
submitted to hydrodynamic effects such as lift forces due to the presence of
walls and drag forces. The temporal evolution of the spatial distribution of
the vesicles has been recorded thanks to digital holographic microscopy, during
parabolic flights and under normal gravity conditions. The collected data
demonstrates that vesicles are pushed away from the walls with a lift velocity
proportional to where is the shear rate,
the vesicle radius and its distance from the wall. This scaling as well
as the dependence of the lift velocity upon vesicle aspect ratio are consistent
with theoretical predictions by Olla [J. Phys. II France {\bf 7}, 1533--1540
(1997)].Comment: 6 pages, 8 figure
Self-assembly by multi-drop evaporation of carbon-nanotube droplets on a polycarbonate substrate
Tuberculosis treatment in a refugee and migrant population: 20 years of experience on the Thai-Burmese border.
Although tuberculosis (TB) is a curable disease, it remains a major global health problem and an important cause of morbidity and mortality among vulnerable populations, including refugees and migrants
Case-Control Study of Risk Factors for Sporadic Giardiasis and Parasite Assemblages in North West England
Giardia duodenalis is a major cause of infectious gastroenteritis worldwide, and it is diversified into eight genetic assemblages (A to H), which are distinguishable only by molecular typing. There is some evidence that the assemblages infecting humans (assemblages A and B) may have different transmission routes, but systematically acquired data, combining epidemiological and molecular findings, are required. We undertook a case-control study with Giardia genotyping in North West England, to determine general and parasite assemblage-specific risk factors. For people without a history of foreign travel, swimming in swimming pools and changing diapers were the most important risk factors for the disease. People infected with assemblage B reported a greater number of symptoms and higher frequencies of vomiting, abdominal pain, swollen stomach, and loss of appetite, compared with people infected with assemblage A. More importantly, keeping a dog was associated only with assemblage A infections, suggesting the presence of a potential zoonotic reservoir for this assemblage. This is the first case-control study to combine epidemiological data with Giardia genotyping, and it shows the importance of integrating these two levels of information for better understanding of the epidemiology of this pathogen
Persistence in surface overflow of Andean rivers
The temporal structure of both deficit (negative) and excess (positive) periods in surface overflow of Andean rivers were analyzed by studying the runs. In Southern areas (in the province of Neuquén and the Southern part of the province of Mendoza), positive and negative groups of anomalies have been found to diminish geometrically over the years. In the Northern areas (in the province of San Juan and Northern part of the province of Mendoza) persistence occurs in negative runs only. This behavior is produced by the influence of the basins located in an arid zone, because of the heterogeneity in the structure of the precipitation in this region.En este trabajo se analiza el comportamiento de la persistencia en el escurrimiento superficial de los rÃos andinos, usando el método de rachas de eventos con anomalÃas positivas o negativas. Se ha encontrado que las rachas positivas o negativas tienen en la zona más austral (provincia de Neuquén y sur de Mendoza) un decaimiento de tipo geométrico con los años; en cambio, hacia la zona más septentrional (provincia de San Juan y norte de Mendoza) aparece la persistencia solamente en las rachas negativas o de sequÃas. Este comportamiento no se encuentra en la estructura de la precipitación que cae en la cuenca, por lo tanto, se infiere que el mismo serÃa debido a la regulación que ejercen las cuencas del norte, inmersas en una región de clima árido.Material digitalizado en SEDICI gracias a la colaboración de la Facultad de Ciencias Astronómicas y GeofÃsicas (UNLP).Asociación Argentina de GeofÃsicos y Geodesta
hypomyelination and congenital cataract neuroimaging features of a novel inherited white matter disorder
BACKGROUND AND PURPOSE: Hypomyelination and congenital cataract (HCC) is an autosomal recessive white matter disease caused by deficiency of hyccin, a membrane protein implicated in both central and peripheral myelination. We aimed to describe the neuroimaging features of this novel entity. MATERIALS AND METHODS: A systematic analysis of patients with unclassified leukoencephalopathies admitted to our institutions revealed 10 children with congenital cataract, slowly progressive neurologic impairment, and diffuse white matter abnormalities on neuroimaging. Psychomotor developmental delay was evident after the first year of life. Peripheral neuropathy was demonstrated by neurophysiologic studies in 9 children. The available neuroimaging studies were retrospectively reviewed. RESULTS: In all patients, neuroimaging revealed diffuse involvement of the supratentorial white matter associated with preservation of both cortical and deep gray matter structures. Supratentorial white matter hypomyelination was detected in all patients; 7 patients also had evidence of variably extensive areas of increased white matter water content. Deep cerebellar white matter hypomyelination was found in 6 patients. Older patients had evidence of white matter bulk loss and gliosis. Proton MR spectroscopy showed variable findings, depending on the stage of the disease. Sural nerve biopsy revealed hypomyelinated nerve fibers. Mutations in the DRCTNNB1A gene on chromosome 7p15.3, causing complete or severe deficiency of hyccin, were demonstrated in all patients. CONCLUSIONS: HCC is characterized by a combined pattern of primary myelin deficiency and secondary neurodegenerative changes. In the proper clinical setting, recognition of suggestive neuroimaging findings should prompt appropriate genetic investigations
Health-related quality of life and functional changes in DMD:A 12-month longitudinal cohort study
Family caregivers of people with amyotrophic lateral sclerosis (ALS) live stressful lives in which they spend most of their time caring for their loved ones and managing difficult situations, thereby reducing the time spent in taking care of themselves. This situation may last several years. Previous literature has widely highlighted that this situation reduces caregivers' quality of life and increases their psychological distress and risk of health problems, but there is a lack of studies that focus on psychological interventions for these situations. This qualitative study examined a pilot experience of two mutual support groups for family caregivers of people with ALS. The aim was to identify caregivers' needs, the prominent aspects of their experience, and to understand whether and how this intervention strategy might help them. Six partners (four men and two women) and six adult children (five women and one man) participated in the groups, which were conducted in northern Italy. After the support groups finished, participants underwent semi-structured interviews. The authors conducted a content analysis of the transcripts of the interviews and the 20 group sessions. The thematic areas identified were "caregiving," "being the son/daughter of a person with ALS," "being the partner of a person with ALS," "group experience" and "group evaluation." The caregiving experience was profoundly different depending on whether the caregiver was a son/daughter or a partner of a patient with ALS. Moreover, comparison with peers and mutual support helped participants to better cope with ALS and its consequences, to improve their care for their relatives and to overcome typical caregiver isolation. These results suggest the usefulness of involving communities in caregiver support in order to create new networks and activate personal and social resources for well-being
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