211 research outputs found
Observation of consequences of sewage sludge disposal by vegetation monitoring of cultivated arable land
Striking elevation in the incidence and prevalence of inflammatory bowel disease in a province of Western Hungary between 1977-2001
AIM: An investigation into inflammatory bowel disease and colorectal cancer in Veszprem Province was conducted from 1977 to 2001.
METHODS: Both hospital and outpatient records were collected and reviewed comprehensively. The majority of patients were followed up regularly.
RESULTS: The population of the province was decreased from 386,000 to 376,000 during the period. Five hundred sixty new cases of ulcerative colitis (UC), 212 of Crohn's disease (CD), and 40 of indeterminate colitis (IC) were diagnosed. The incidence rates increased from 1.66 to 11.01 cases per 100,000 persons for UC, from 0.41 to 4.68 for CD and from 0.26 to 0.74 for IC. The prevalence rate at the end of 2001 was 142.6 for UC and 52.9 cases per 100,000 persons for CD. The peak onset age in UC patients was between 30 and 40 years, in CD between 20 and 30 years. A family history of IBD was present in 3.4 % in UC and 9.9 % in CD patients. Smoking increased the risk for CD (OR=1.98) while it decreased the risk for UC (OR=0.25). Twelve colorectal carcinomas were observed in this cohort, the cumulative colorectal cancer risk after 10 years in UC was 2%, after 20 years 8.8%, after 30 years 13.3%.
CONCLUSION: The incidence and prevalence rates of IBD have increased steadily in Veszprem Province, now equivalent to that in Western European countries. Rapid increase in incidence rates supports a probable role for environmental factors. The rate of colorectal cancers in IBD is similar to that observed in Western countries
HER2-pozitív emlőtumorok célzott terápiájában alkalmazott szerek és a terápiás válasz előrejelzése
Következő generációs szekvenálási technológiák kifejlődése és alkalmazásai
In the past ten years the development of next generation sequencing technologies brought a new era in the field of quick and efficient DNA sequencing. In our study we give an overview of the methodological achievements from Sanger's chain-termination sequencing in 1975 to those allowing real-time DNA sequencing today. Sequencing methods that utilize clonal amplicons for parallel multistrand sequencing comprise the basics of currently available next generation sequencing techniques. Nowadays next generation sequencing is mainly used for basic research in functional genomics, providing quintessential information in the meta-analyses of data from signal transduction pathways, onthologies, proteomics and metabolomics. Although next generation sequencing is yet sparsely used in clinical practice, cardiology, oncology and epidemiology already show an immense need for the additional knowledge obtained by this new technology. The main barrier of its spread is the lack of standardization of analysis evaluation methods, which obscure objective assessment of the results. Orv. Hetil., 2011, 152, 55-62
Effect of advanced oxidation pretreatments on membrane filtration of protein containing waste waters
PURIFICATION OF OIL CONTAMINATED WATER BY DIFFERENT ADVANCED OXIDATION PROCESSES COMBINED WITH MEMBRANE FILTRATION
Purification of Model Dairy Wastewaters by Ozone, Fenton Pre-treatment and Membrane Filtration
This study aimed to investigate the effect of ozone and Fenton-reaction as a pre-treatment before ultrafiltration of model dairy waste waters containing sodium caseinate. Filtration resistances and pollutant retentions were determined and compared. It was found, that both pre-treatment increased the retention, achieving almost 100 % pollutant elimination efficiency after short term pre-oxidation. The effect of Fe-ion concentration on Fenton pretreatment efficiency also was examined, and it was found that higher concentration resulted in decreased filtration resistances, revealing that coagulation-flocculation effect of reactants has dominant role in the protein separation efficiency. The presence of lactose also affects the pollutant removal efficiency, it promotes fouling in presence of Fenton reagents
TRADITION, QUALITY AND BIOTECHNOLOGY IN HUNGARIAN SPICE PEPPER (Capsicum annuum L.) BREEDING
Spice pepper production has a history of almost 300 years in the southern part of
Hungary. In this study the results of two biotechnological improvements are summarized.
Anther and isolated microspore culture techniques were improved to release haploid and
doubled haploid (DH) lines for spice pepper breeding. Both the anther and isolated
microspore culture methods were successfully used in spice pepper haploid production.
Microspore culture- derived structures were analysed to identify their different parts.
Green plantlets were regenerated from embryos derived from both anther and microspore
cultures. Their doubled haploid analogues were integrated into Hungarian spice pepper
hybrid seed breeding programmes. One hybrid, Sláger, was released as a new genotype for
spice pepper production in 2008 and two hybrid candidates (Délibáb and Bolero) are now
being tested in official trials
Present practice of thrombosis prophylaxis of radical prostatectomy in a European country - a Hungarian multicenter study
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