Quantum effects in the diffusion of hydrogen on Ru(0001)

An understanding of hydrogen diffusion on metal surfaces is important, not just for its role in heterogeneous catalysis and hydrogen fuel cell technology, but also because it provides model systems where tunneling can be studied under well-defined conditions. Here we report helium spin-echo measurements of the atomic-scale motion of hydrogen on the Ru(0001) surface between 75 and 250 K. Quantum effects are evident at temperatures as high as 200 K, while below 120 K we observe a tunneling-dominated temperature independent jump rate of 1.9$\times$10$^9$ s$^{-1}$, many orders of magnitude faster than previously seen. Quantum transition state theory calculations based on ab initio path-integral simulations reproduce the temperature dependence of the rate at higher temperatures and predict a crossover to tunneling-dominated diffusion at low temperatures, although the tunneling rate is under-estimated, highlighting the need for future experimental and theoretical studies of hydrogen diffusion on well-defined surfaces.Comment: 15 pages, 3 figure

Inherited retinal diseases: Therapeutics, clinical trials and end points—A review

Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of disorders characterised by photoreceptor degeneration or dysfunction. These disorders typically present with severe vision loss that can be progressive, with disease onset ranging from congenital to late adulthood. The advances in genetics, retinal imaging and molecular biology, have conspired to create the ideal environment for establishing treatments for IRDs, with the first approved gene therapy and the commencement of multiple clinical trials. The scope of this review is to familiarise clinicians and scientists with the current management and the prospects for novel therapies for: (1) macular dystrophies, (2) cone and cone‐rod dystrophies, (3) cone dysfunction syndromes, (4) Leber congenital amaurosis, (5) rod‐cone dystrophies, (6) rod dysfunction syndromes and (7) chorioretinal dystrophies. We also briefly summarise the investigated end points for the ongoing trials

Association of geopotential height patterns with heavy rainfall events in Cyprus

Dynamically induced rainfall is strongly connected with synoptic atmospheric circulation patterns at the upper levels. This study investigates the relationship between days of high precipitation volume events in the eastern Mediterranean and the associated geopotential height patterns at 500 hPa. To reduce the number of different patterns and to simplify the statistical processing, the input days were classified into clusters of synoptic cases having similar characteristics, by utilizing Kohonen Self Organizing Maps (SOM) architecture. Using this architecture, synoptic patterns were grouped into 9, 18, 27 and 36 clusters which were subsequently used in the analysis. The classification performance was tested by applying the method to extreme rainfall events in the eastern Mediterranean. The relationship of the synoptic upper air patterns (500 hPa height) and surface features (heavy rainfall events) was established, while the 36 member classification proved to be the most efficient

The cold frontal depression that affected the area of Cyprus between 28 and 29 January 2008

The baroclinic depression that affected the area of Cyprus during the cold period, between 28 and 29 January 2008 was thoroughly studied and is presented in the present paper. A small perturbation on a northwesterly flow to the north of Cyprus has initiated the generation of the depression and in 24 h this developed into a deep baroclinic system. This depression was associated with intense weather phenomena, such as heavy thunderstorms with hail and near gale force winds. Strong cold advection resulted in a significant temperature decrease; precipitation even in lower altitudes was in the form of snow, while the accumulated rainfall corresponded to the 25% of the monthly normal. January 2008 is considered as a dry month, despite the fact that, on the average, January is considered as the wettest month of the year. In this study, the evolution and development of the depression was investigated from synoptic, dynamic, energetic and thermodynamic perspectives, in order to enhance our knowledge on the life cycle and behaviour of similar depressions over the area with extreme characteristics

OCT angiography in the management of choroidal neovascular membrane secondary to Sorsby fundus dystrophy

We describe the management of a woman aged 52 years with molecularly confirmed Sorsby fundus dystrophy, who presented with acute visual deterioration in her right eye. Fundus examination identified a right macular lesion suggestive of a choroidal neovascular membrane (CNVM). Optical coherence tomography angiography (OCTA) confirmed the presence of a CNVM. She was treated with 2 monthly intravitreal injections of bevacizumab, associated with OCTA evidence of regression of the CNVM and improvement in her visual acuity. OCTA is a novel, non-invasive method of imaging the retinal vasculature. Images are acquired rapidly, with no associated side effects, offering advantages over the current gold standard technique-fundus fluorescein angiography

Stargardt disease: clinical features, molecular genetics, animal models and therapeutic options

Stargardt disease (STGD1; MIM 248200) is the most prevalent inherited macular dystrophy and is associated with disease-causing sequence variants in the gene ABCA4 Significant advances have been made over the last 10 years in our understanding of both the clinical and molecular features of STGD1, and also the underlying pathophysiology, which has culminated in ongoing and planned human clinical trials of novel therapies. The aims of this review are to describe the detailed phenotypic and genotypic characteristics of the disease, conventional and novel imaging findings, current knowledge of animal models and pathogenesis, and the multiple avenues of intervention being explored

Local investigation of femtosecond laser induced dynamics of water nanoclusters on Cu(111)

We explore the dynamics of low temperature interfacial water nanoclusters on Cu(111) by femtosecond-laser excitation, scanning tunneling microscopy and density functional theory. Laser illumination can be used to induce single molecules to diffuse within water clusters and across the surface, breaking and reforming hydrogen bonds. A linear diffusion probability with laser fluence is observed up to 0.6 J/m2 and we suggest that diffusion is initiated by hot electron attachment and detachment processes. The density functional calculations shed light on the detailed molecular mechanism for water diffusion that is determined by the local structure of the water clusters

A statistical analysis of sounding derived indices and parameters for extreme and non-extreme thunderstorm events over Cyprus

The main purpose of this study is to provide a simple statistical analysis of several stability indices and parameters for extreme and non-extreme thunderstorm events during the period 1997 to 2001 in Cyprus. For this study, radiosonde data from Athalassa station (35°1´ N, 33°4´ E) were analyzed during the aforementioned period. The stability indices and parameters set under study are the K index, the Total Totals (TT) index, the Convective Available Potential Energy related parameters such as Convective Available Potential Energy (CAPE), Downdraft CAPE (DCAPE) and the Convective Inhibition (CIN), the Vorticity Generator Parameter (VGP), the Bulk Richardson Number (BRN), the BRN Shear and the Storm Relative Helicity (SRH). An event is categorized as extreme, if primarily, CAPE was non zero and secondary, if values of both the K and the TotalTotals (TT) indices exceeded 26.9 and 50, respectively. The cases with positive CAPE but lower values of the other indices, were identified as non-extreme. By calculating the median, the lower and upper limits, as well as the lower and upper quartiles of the values of these indices, the main characteristics of their distribution were determined